Claire‐Anne Gutekunst

Exercise evokes retained motor performance without neuroprotection in a mouse model of Parkinson’s disease

Henry M. Skelton, N. Hyman, Alejandra M. Fernandez, Emma Acerbo et autres

Exercise has been extensively studied in Parkinson's Disease, with a particular focus on the potential for neuroprotection that has been demonstrated in animal models. While this preclinical work has provided insight into the underlying molecular mechanisms, it has not addressed the neurophysiological …

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Non-invasive temporal interference stimulation of the hippocampus suppresses epileptic biomarkers in patients with Epilepsy: biophysical differences between kilohertz and amplitude modulated stimulation

Florian Missey, Emma Acerbo, Adam S. Dickey, Jan Trajlínek et autres

Deep brain stimulation of the anterior nucleus of the thalamus in animal models of mesial temporal lobe epilepsy: A literature review

Emma Acerbo, Thomas E. Eggers, Alejandra M. Fernandez, Robert E. Gross et autres

Epilepsy affects approximately 1 % of the global population, presenting as a complex and heterogeneous disorder characterized by spontaneous, recurrent seizures. Focal onset seizures comprise half of all epilepsy cases. Mesial temporal lobe epilepsy (MTLE), the most prevalent form of focal seizures …

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Non-invasive Temporal Interference Stimulation of the Hippocampus Suppresses Epileptic Biomarkers in Patients with Epilepsy: Biophysical Differences between Kilohertz and Amplitude Modulated Stimulation

Florian Missey, Emma Acerbo, Adam S. Dickey, Jan Trajlínek et autres

Medication refractory focal epilepsy creates a significant challenge, with approximately 30% of patients ineligible for surgery due to the involvement of eloquent cortex in the epileptogenic network. For such patients with limited surgical options, electrical neuromodulation represents a promising alternative therapy. In …

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Adaptive wheel exercise for mouse models of Parkinson’s Disease

Henry M. Skelton, Dayton P. Grogan, Amrutha Kotlure, Ken Berglund et autres

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Organellular imaging in vivo reveals a depletion of endoplasmic reticular calcium during post-ictal cortical spreading depolarization

Matthew Stern, Eric R. Cole, Claire‐Anne Gutekunst, Jenny Jie Yang et autres

During cortical spreading depolarization (CSD), neurons exhibit a dramatic increase in cytosolic calcium, which may be integral to CSD-mediated seizure termination. This calcium increase greatly exceeds that during seizures, suggesting the calcium source may not be solely extracellular. Thus, we sought to …

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Refining Brain Stimulation Therapies: An Active Learning Approach to Personalization

Mohammad S.E. Sendi, Eric R. Cole, Brigitte Piallat, Charles A. Ellis et autres

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Refining Brain Stimulation Therapies: An Active Learning Approach to Personalization

Mohammad SE Sendi, Eric R. Cole, Brigitte Piallat, Charles A. Ellis et autres

Abstract Brain stimulation holds promise for treating brain disorders, but personalizing therapy remains challenging. Effective treatment requires establishing a functional link between stimulation parameters and brain response, yet traditional methods like random sampling (RS) are inefficient and costly. To overcome this, we …

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Seizure onset and offset pattern determine the entrainment of the cortex and substantia nigra in the nonhuman primate model of focal temporal lobe seizures

Mark J. Connolly, Sujin Jiang, Lim C. Samuel, Claire‐Anne Gutekunst et autres

Temporal lobe epilepsy (TLE) is the most common form of drug-resistant epilepsy. A major focus of human and animal studies on TLE network has been the limbic circuit. However, there is also evidence suggesting an active role of the basal ganglia in …

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Effects of acute hippocampal stimulation in the nonhuman primate penicillin model of temporal lobe seizures

Mark J. Connolly, Brigitte Piallat, Mohammad S.E. Sendi, Babak Mahmoudi et autres

seizure models. To further evaluate its effects on a pre-clinical model, we characterized the effect of unilateral ADMES in an NHP model of temporal lobe seizures induced by intra-hippocampal injection of penicillin (PCN). Four non-human primates were used for this study in …

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Adaptive Wheel Exercise for Mouse Models of Parkinson’s Disease

Henry M. Skelton, Dayton P. Grogan, Amrutha Kotlure, Ken Berglund et autres

Abstract Exercise is widely studied as a therapy in mouse models of neurological disease. However, the established techniques for exercise in mice are not ideally suited toward motor deficient disease models, nor do they facilitate active measurement of neurophysiology with tethered assays. …

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Improved Temporal and Spatial Focality of Non-invasive Deep-brain Stimulation using Multipolar Single-pulse Temporal Interference with Applications in Epilepsy

Emma Acerbo, Boris Botzanowski, Damián Dellavale, Matthew Stern et autres

Abstract Temporal Interference (TI) is an emerging method to non-invasively stimulate deep brain structures. This innovative technique is increasingly recognized for its potential applications in the treatment of various neurological disorders, including epilepsy, depression, and Alzheimer’s disease. However, several drawbacks to the …

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