Seizure onset and offset pattern determine the entrainment of the cortex and substantia nigra in the nonhuman primate model of focal temporal lobe seizures
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Temporal lobe epilepsy (TLE) is the most common form of drug-resistant epilepsy. A major focus of human and animal studies on TLE network has been the limbic circuit. However, there is also evidence suggesting an active role of the basal ganglia in the propagation and control of temporal lobe seizures. Here, we characterize the involvement of the substantia nigra (SN) and somatosensory cortex (SI) during temporal lobe (TL) seizures induced by penicillin injection in the hippocampus (HPC) of two nonhuman primates. The seizure onset and offset patterns were manually classified and spectral power and coherence were calculated. We then compared the 3-second segments recorded in pre-ictal, onset, offset and post-ictal periods based on the seizure onset and offset patterns. Our results demonstrated an involvement of the SN and SI dependent on the seizure onset and offset pattern. We found that low amplitude fast activity (LAF) and high amplitude slow activity (HAS) onset patterns were associated with an increase in activity of the SN while the change in activity was limited to LAF seizures in the SI. However, the increase in HPC/SN coherence was specific to the farther-spreading LAF onset pattern. As for the role of the SN in seizure cessation, we observed that the coherence between the HPC/SN was reduced during burst suppression (BS) compared to other termination phases. Additionally, we found that this coherence returned to normal levels after the seizure ended, with no significant difference in post-ictal periods among the three types of seizure offsets. This study constitutes the first demonstration of TL seizures entraining the SN in the primate brain. Moreover, these findings provide evidence that this entrainment is dependent on the onset and offset pattern and support the hypothesis that the SN might play a role in the maintenance and termination of some specific temporal lobe seizure.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Seizure onset and offset pattern determine the entrainment of the cortex and substantia nigra in the nonhuman primate model of focal temporal lobe seizures
- Date Crossref
- 28/08/2024
- Éditeur
- Public Library of Science (PLoS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Georgia Institute of Technology Wallace H. Coulter Department of Biomedical Engineering pays non établi dans la noticeUniversité ou école supérieure
-
Emory University Emory National Primate Research Center pays non établi dans la noticeUniversité ou école supérieure
-
The Wallace H. Coulter Department of Biomedical Engineering pays non établi dans la noticeUniversité ou école supérieure
-
The State University of New Jersey Rutgers pays non établi dans la noticeUniversité ou école supérieure
-
Johnson University pays non établi dans la noticeUniversité ou école supérieure
-
Emory College of Arts & Sciences pays non établi dans la noticeUniversité ou école supérieure
-
Rutgers University Department of Neurosurgery pays non établi dans la noticeUniversité ou école supérieure
Wallace H. Coulter Department of Biomedical Engineering — Georgia Institute of Technology, Emory National Primate Research Center — Emory University et The Wallace H. Coulter Department of Biomedical Engineering, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.