Emma Acerbo

Direct delivery of modulated kilohertz frequency waveforms enable simultaneous electrical stimulation and recording with minimal-artifact

Thomas E. Eggers, Emma Acerbo, Neal Laxpati, Claire-Anne Gutekunst

Abstract Objective. Kilohertz frequency waveforms have received increasing attention in the field of neuromodulation in recent years. These waveforms are frequently used to develop transcutaneous stimulation therapies, although they have also been used with implanted electrodes. While the goal is non- or …

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Exercise evokes retained motor performance without neuroprotection in a mouse model of Parkinson’s disease

Henry M. Skelton, N. Hyman, Alejandra M. Fernandez, Emma Acerbo et autres

Exercise has been extensively studied in Parkinson's Disease, with a particular focus on the potential for neuroprotection that has been demonstrated in animal models. While this preclinical work has provided insight into the underlying molecular mechanisms, it has not addressed the neurophysiological …

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Safety assessment of temporal interference stimulation

Richard Hou, Emma Acerbo, Ryohei Yoshimoto, Nealen Gordon Laxpati et autres

Temporal interference (TI) stimulation is a promising non-invasive neuromodulation strategy that uses two high-frequency electric fields to generate a low-frequency amplitude-modulated envelope at their intersection, enabling targeting of deep brain regions. However, in vivo safety concerns remain regarding the impact of the …

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Non-invasive temporal interference stimulation of the hippocampus suppresses epileptic biomarkers in patients with Epilepsy: biophysical differences between kilohertz and amplitude modulated stimulation

Florian Missey, Emma Acerbo, Adam S. Dickey, Jan Trajlínek et autres

Non-invasive temporal interference stimulation of the hippocampus suppresses epileptic biomarkers in patients with Epilepsy: biophysical differences between kilohertz and amplitude modulated stimulation

Florian Missey, Emma Acerbo, Adam S. Dickey, Jan Trajlínek et autres

INTRODUCTION: Medication-refractory focal epilepsy creates a significant clinical challenge, with approximately 30 % of patients deemed ineligible for surgery due to involvement of eloquent cortical regions within the epileptogenic network. For these patients, electrical neuromodulation represents a promising alternative therapy. We investigated …

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Deep brain stimulation of the anterior nucleus of the thalamus in animal models of mesial temporal lobe epilepsy: A literature review

Emma Acerbo, Thomas E. Eggers, Alejandra M. Fernandez, Robert E. Gross et autres

Epilepsy affects approximately 1 % of the global population, presenting as a complex and heterogeneous disorder characterized by spontaneous, recurrent seizures. Focal onset seizures comprise half of all epilepsy cases. Mesial temporal lobe epilepsy (MTLE), the most prevalent form of focal seizures …

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Frequency‐specific alterations in brain connectivity induced by pulvinar stimulation

Emma Acerbo, Aude Jegou, Stanislas Lagarde, Francesca Pizzo et autres

OBJECTIVE: Deep brain stimulation (DBS) is emerging as a promising therapy for patients with drug-resistant epilepsy, particularly those who are either unsuitable for or unresponsive to resective surgery. The potential benefit of DBS in these patients may stem from its ability to …

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Additional file 1 of Focal control of non-invasive deep brain stimulation using multipolar temporal interference

Boris Botzanowski, Emma Acerbo, Sebastian Lehmann, Sarah L. Kearsley et autres

Supplementary Material 1. Supplementary Figure 1. Phase interactions in mTI.Two envelopes, in phase, create a larger aggregate envelope.Two envelopes, with offset phase, create an poorly defined aggregate envelope.Two envelopes, with 180 degree phase offset, create no aggregate envelope. It is important to …

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Focal control of non-invasive deep brain stimulation using multipolar temporal interference

Boris Botzanowski, Emma Acerbo, Sebastian Lehmann, Sarah L. Kearsley et autres

Temporal interference (TI) is a method of non-invasive brain stimulation using transcutaneous electrodes which allows the targeting and modulation of deeper brain structures, not normally associated with non-invasive simulation, while avoiding unwanted stimulation of shallower cortical structures. The properties of TI have …

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Clinical Results of Non-invasive Deep Brain Stimulation in Epilepsy and Parkinson’s patients using Temporal Interference

Adam Williamson, Florian Missey, Emma Acerbo, Martin Lamoš et autres

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Enhanced temporal interference stimulation: pulsed and multipolar techniques for improved deep brain modulation

Adam Williamson, Florian Missey, Emma Acerbo, Martin Lamoš et autres

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Non-invasive Temporal Interference Stimulation of the Hippocampus Suppresses Epileptic Biomarkers in Patients with Epilepsy: Biophysical Differences between Kilohertz and Amplitude Modulated Stimulation

Florian Missey, Emma Acerbo, Adam S. Dickey, Jan Trajlínek et autres

Medication refractory focal epilepsy creates a significant challenge, with approximately 30% of patients ineligible for surgery due to the involvement of eloquent cortex in the epileptogenic network. For such patients with limited surgical options, electrical neuromodulation represents a promising alternative therapy. In …

fr, cz, us, hu, it, ch, se (code pays fourni par la source)