Claudio Henrique T. Ribeiro

Glutamine antagonism suppresses tumor growth in adrenocortical carcinoma through inhibition of de novo nucleotide biosynthesis

Vasileios Chortis, Kleiton Silva Borges, Cong-Hui Yao, Claudio Henrique T. Ribeiro et autres

Abstract Dysregulation of cellular metabolism is a hallmark of cancer, which remains poorly understood in adrenocortical carcinoma (ACC). Here, we dissected ACC metabolism by integrating transcriptional profiling from human and mouse ACC, targeted tissue metabolomics from a mouse ACC model, and untargeted …

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Abrogation of FGFR signaling blocks β-catenin–induced adrenocortical hyperplasia and aldosterone production

Vasileios Chortis, Dulanjalee Kariyawasam, Mesut Berber, Nick A. Guagliardo et autres

Fibroblast growth factor receptors (FGFRs) are tyrosine kinase receptors critical for organogenesis and tissue maintenance, including in the adrenal gland. Here we delineate the role of FGFR2 in the morphogenesis, maintenance, and function of the adrenal cortex with a focus on the …

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Cover Image, Volume 45, Issue 6

Katia Mariniello, James F. H. Pittaway, Barbara Altieri, Kleiton Silva Borges et autres

The cover image is based on the article Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma by James Pittaway et al., https://doi.org/10.1002/cac2.70012 . image

Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma

Katia Mariniello, James F. H. Pittaway, Barbara Altieri, Kleiton Silva Borges et autres

Adrenocortical carcinoma (ACC) is a rare malignancy with no widely available biomarkers and commonly presents at later stages with a bleak prognosis (1). Dysregulation of signaling pathways involved in the organogenesis and homeostasis of the adrenal cortex is implicated in its pathogenesis …

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Glutamine antagonism as a new treatment approach in adrenocortical carcinoma

Vasileios Chortis, Cong-Hui Yao, Claudio Henrique T. Ribeiro, Mesut Berber et autres

In vivo CRISPR screening identifies tada2b as a key epigenetic regulator of immune response in adrenocortical carcinoma

Kleiton Silva Borges, Claudio Henrique T. Ribeiro, Audrey J. Muscato, Celeste Nobrega et autres

7887 Non-Canonical Wnt Signaling Via WNT2B Is Critical For Adrenal Morphogenesis and Aldosterone Production

Kleiton Silva Borges, Donald W. Little, Taciani de Almeida Magalhães, Claudio Henrique T. Ribeiro et autres

Abstract Disclosure: K.S. Borges: None. D.W. Little III: None. T. de Almeida Magalhães: None. C. Ribeiro: None. K. Basham: None. T. Dumonte: None. S. Azova: None. A.E. O’Connell: None. N.A. Guagliardo: None. P.Q. Barrett: None. M. Berber: None. D. Mohan: None. A. …

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Non-canonical Wnt signaling triggered by WNT2B drives adrenal aldosterone production

Kleiton Silva Borges, Donald W. Little, Taciani de Almeida Magalhães, Claudio Henrique T. Ribeiro et autres

Abstract The steroid hormone aldosterone, produced by the zona glomerulosa (zG) of the adrenal gland, is a master regulator of plasma electrolytes and blood pressure. While aldosterone control by the renin-angiotensin system is well understood, other key regulatory factors have remained elusive. …

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Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma

Katia Mariniello, James F. H. Pittaway, Barbara Altieri, Kleiton Silva Borges et autres

Abstract Disruption of processes involved in tissue development and homeostatic self-renewal is increasingly implicated in cancer initiation, progression, and recurrence. The adrenal cortex is a dynamic tissue that undergoes life-long turnover. Here, using genetic fate mapping and murine adrenocortical carcinoma (ACC) models, …

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Extended-height magnetic matrices to increase ultra - fine mineral particle recovery

José Pancrácio Ribeiro, Claudio Henrique T. Ribeiro, Anderson de Araújo Soares, Klaydison Silva et autres

In response to the challenge of recovering particles smaller than -0.45 microns in Mineral Processing, GAUSTEC® has significantly enhanced the Wet High Intensity Magnetic Separation (WHIMS) technology. By Extending the Height of the Magnetic Grooved Plate Matrix, a core component of Jones …

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OR04-2 WNT2B Deficiency Results in Hyperreninemic Hypoaldosteronism in Humans and Mice

Svetlana Azova, Kaitlin J. Basham, David T. Breault, Gary Douglas Hammer et autres

Abstract Proper development and zonation of the adrenal cortex is intimately connected with its lifelong capacity to produce steroid hormones. Both adrenocortical development and homeostasis are mediated in part by paracrine WNT/β-catenin signaling, an essential pathway for zonal maintenance and aldosterone production. …

The BigFLUX Magnetic Matrix Technology

José Pancrácio Ribeiro, Claudio Henrique T. Ribeiro, Eric Guimarães Vieira

The Magnetic separation of ultra-fine ore particles has always posed a challenge to the JONES/WHIMS process. Despite many advances in this technology, no effective improvement has been made to its core component: The Magnetic Matrix. The current approach to separate ultra-fine particles …

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