Judit Marsillach

Investigating biomarkers of exposure to jet aircraft oil fumes using mass spectrometry

Clement E. Furlong, Rebecca J. Richter, Judit Marsillach, Alex Zelter et autres

Abstract Most commercial passenger jet aircraft use compressed engine air after cooling as a source for ventilation and cabin pressurization onboard. This “bleed air” design means that engine oil and/or hydraulic fluid can contaminate the ventilation supply air during otherwise normal flights, …

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Impact of Antioxidant and Anti-Inflammatory Functions of HDL in Diseases—2nd Edition

Carlo Cervellati, Judit Marsillach

In recent decades, significant advancements in lipidology have profoundly reshaped our understanding of the biological roles of lipids and lipoproteins, particularly high-density lipoproteins (HDLs) [...].

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PON1 Status in Relation to Gulf War Illness: Evidence of Gene–Exposure Interactions from a Multisite Case–Control Study of 1990–1991 Gulf War Veterans

Lea Steele, Clement E. Furlong, Rebecca J. Richter, Judit Marsillach et autres

Background: Deployment-related neurotoxicant exposures are implicated in the etiology of Gulf War illness (GWI), the multisymptom condition associated with military service in the 1990–1991 Gulf War (GW). A Q/R polymorphism at position 192 of the paraoxonase (PON)-1 enzyme produce PON1192 variants with …

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Advances in the Use of Residual Newborn Dried Blood Spots Within Environmental Epidemiology

Rothboury A. Doung, Jacqueline M. Garrick, Judit Marsillach

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Inhibition with simultaneous spontaneous reactivation and aging of acetylcholinesterase by organophosphorus compounds: Demeton-S-methyl as a model

Jorge Estévez, Luis Pizarro, Judit Marsillach, Clement E. Furlong et autres

The kinetic analysis of esterase inhibition by acylating compounds (organophosphorus, carbamates and sulfonylfluorides) sometimes cannot yield consistent results by fitting simple inhibition kinetic models to experimental data of complex systems. In this work kinetic data were obtained for demeton-S-methyl (DSM) with human …

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Reduction of Paraoxonase Expression Followed by Inactivation across Independent Semiaquatic Mammals Suggests Stepwise Path to Pseudogenization

Allie M. Graham, Jerrica M. Jamison, Marisol Bustos, Charlotte Cournoyer et autres

Convergent adaptation to the same environment by multiple lineages frequently involves rapid evolutionary change at the same genes, implicating these genes as important for environmental adaptation. Such adaptive molecular changes may yield either change or loss of protein function; loss of function …

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Lipoprotein-Associated Phospholipase A2 Activity as Potential Biomarker of Vascular Dementia

Giovanni Zuliani, Judit Marsillach, Alessandro Trentini, Valentina Rosta et autres

A wealth of evidence suggests that Lipoprotein-associated phospholipase A2 (Lp-PLA2) plays a relevant role in atherogenesis and inflammation, which in turn are associated with the risk of developing dementia. The aim of this study was to evaluate whether serum Lp-PLA2 activity might …

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Reduction of Paraoxonase expression followed by inactivation across independent semiaquatic mammals suggests stepwise path to pseudogenization

Allie M. Graham, Jerrica M. Jamison, Marisol Bustos, Charlotte Cournoyer et autres

ABSTRACT Convergent adaptation to the same environment by multiple lineages frequently involves rapid evolutionary change at the same genes, implicating these genes as important for environmental adaptation. Such adaptive molecular changes may yield either change or loss of protein function; loss of …

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Examining the role of paraoxonase 2 in the dopaminergic system of the mouse brain

Jacqueline M. Garrick, Khoi Thien Dao, Lucio Guido Costa, Judit Marsillach et autres

BACKGROUND: Paraoxonase 2 (PON2) is an intracellular antioxidant enzyme located at the inner mitochondrial membrane. Previous studies have found PON2 to be an important antioxidant in a variety of cellular systems, such as the cardiovascular and renal system. Recent work has also …

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Paraoxonase-1 (PON-1) Arylesterase Activity Levels in Patients with Coronary Artery Disease: A Meta-Analysis

Marco Zuin, Alessandro Trentini, Judit Marsillach, Andrea D’Amuri et autres

Aim. To review and compare the PON-1 arylesterase activity between coronary artery disease (CAD) and non-CAD patients. Methods. Data were obtained by searching MEDLINE and Scopus for all investigations published between January 1, 2000 and March 1, 2021 comparing PON-1 arylesterase activity …

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Contributors

Manoj Aggarwal, James A. Akingbasote, Arturo Anadón, Gregory J. Anger et autres

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Traffic-related air pollution and the developing brain

Lucio Guido Costa, Jacqueline M. Garrick, Khoi Thien Dao, Ashley Phillips et autres

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