Alessandro Trentini

Dysfunctional mitophagy in Alzheimer’s disease: evidence from peripheral Optineurin

Simone Patergnani, Alessandro Trentini, Valentina Rosta, Paola Guindani et autres

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Reduced Serum PON1 Lactonase Activity Is Associated with Mild Cognitive Impairment and Mixed Dementia

Raffaella Riccetti, Alessandro Trentini, Gianmarco Mola, Gloria Brombo et autres

High-density lipoprotein (HDL)-associated paraoxonase-1 (PON1) contributes substantially to the antioxidant and anti-inflammatory functions of HDL. Impairment of these protective properties has been associated with Alzheimer’s disease (AD) and other forms of dementia, particularly those involving neurovascular dysregulation. In the present study, we …

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Identification of physiological clusters in acute hypoxemic respiratory failure patients undergoing non-invasive respiratory support using EIT-based t-SNE and spectral clustering

Gaetano Scaramuzzo, Valentina Bellini, Matteo Trevisani, Francesca Cinquegrana et autres

PURPOSE: Identifying physiological clusters in acute hypoxemic respiratory failure (AHRF) may help to personalize non-invasive respiratory support (NIRS). Electrical impedance tomography (EIT) provides real-time, regional information on tidal ventilation, but its value for clustering AHRF patients undergoing NIRS has not been established. …

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Additional file 1 of Identification of physiological clusters in acute hypoxemic respiratory failure patients undergoing non-invasive respiratory support using EIT-based t-SNE and spectral clustering

Gaetano Scaramuzzo, Valentina Bellini, Matteo Trevisani, Francesca Cinquegrana et autres

Supplementary material 1.

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Identification of physiological clusters in acute hypoxemic respiratory failure patients undergoing non-invasive respiratory support using EIT-based t-SNE and spectral clustering

Gaetano Scaramuzzo, Valentina Bellini, Matteo Trevisani, Francesca Cinquegrana et autres

Abstract Purpose Identifying physiological clusters in acute hypoxemic respiratory failure (AHRF) may help to personalize non-invasive respiratory support (NIRS). Electrical impedance tomography (EIT) provides real-time, regional information on tidal ventilation, but its value for clustering AHRF patients undergoing NIRS has not been …

it (code pays fourni par la source)

Identification of physiological clusters in acute hypoxemic respiratory failure patients undergoing non-invasive respiratory support using EIT-based t-SNE and spectral clustering

Gaetano Scaramuzzo, Valentina Bellini, Matteo Trevisani, Francesca Cinquegrana et autres

Abstract Purpose Identifying physiological clusters in acute hypoxemic respiratory failure (AHRF) may help to personalize non-invasive respiratory support (NIRS). Electrical impedance tomography (EIT) provides real-time, regional information on tidal ventilation, but its value for clustering AHRF patients undergoing NIRS has not been …

it (code pays fourni par la source)

Additional file 1 of Identification of physiological clusters in acute hypoxemic respiratory failure patients undergoing non-invasive respiratory support using EIT-based t-SNE and spectral clustering

Gaetano Scaramuzzo, Valentina Bellini, Matteo Trevisani, Francesca Cinquegrana et autres

Supplementary material 1.

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Myeloperoxidase (MPO) Enzymatic Activity, but Not Its Protein Concentration, Is Associated with the Risk of Type 2 Diabetes in Females, Regardless of Obesity Status

Alessandro Trentini, Raffaella Riccetti, Domenico Sergi, Juana María Sanz et autres

To date, neutrophil-derived myeloperoxidase (MPO), a key mediator of inflammation and oxidative stress, has predominantly been assessed in peripheral fluids by protein concentration rather than enzymatic activity, mainly due to methodological limitations. However, MPO activity directly reflects the enzyme’s cytotoxic potential and …

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Sex-difference in the association between Triglyceride-Glucose (TyG) index and dementia

Giovanni Zuliani, Gloria Brombo, Francesco di Paola Dario, Marco Zuin et autres

Purpose: This study aims to evaluate the association between the insulin resistance as assessed by Triglyceride-Glucose (TyG) index and dementia and to determine whether this relationship varies by sex. Methods: We assessed TyG index in older patients admitted to an Italian Memory …

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Effect of Dietary PUFAs and Antioxidants on Antioxidant and Anti-Inflammatory Functions of HDL in a Cohort of Women

Gianmarco Mola, Raffaella Riccetti, Domenico Sergi, Alessandro Trentini et autres

High-density lipoproteins (HDLs) protect against atherosclerosis through their antioxidant, anti-inflammatory, and other beneficial properties. Although interest is increasing in uncovering both physiological and external factors that influence these functions, definitive evidence remains lacking in this area. To fill this gap, we assessed …

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Mechanisms, Mediators, and Pharmacological Approaches Targeting Brain Cholesterol Transport in Alzheimer’s Disease

Martina Ugolotti, Bianca Papotti, Alessandro Trentini, Gianmarco Mola et autres

Cholesterol transport within the brain represents a highly regulated process essential for maintaining neuronal function and central nervous system (CNS) homeostasis. Unlike peripheral tissues, the brain relies on in situ cholesterol synthesis, primarily by astrocytes and other glial cells, which supply neurons …

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Commentary on the Issue of Leishmania Infection: Focus on Some Pathogenetic, Clinical, and Epidemiological Aspects

Stefania Hanau, Martina Maritati, Carlo Contini, Alessandro Trentini et autres

Leishmaniasis are infectious diseases caused by several parasitic species of Leishmania, mainly transmitted by the bite of infected phlebotomine sandflies. Humans, dogs, rodents, and other domestic and wild animals can act as reservoir hosts for the different Leishmania species. It is a …

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