Pan-cancer analyses reveal GTSE1 as a biomarker for the immunosuppressive tumor microenvironment
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Le résumé fourni par la source
G2 and S phase-expressed-1 (GTSE1) has been reported to be associated with poor prognosis in many cancer types. However, the knowledge of GTSE1 across 33 cancer types remains scarce, and the mechanisms by which GTSE1 promotes cancer development remain incompletely understood. R language and TIMER2.0 were used to analyze the clinical relevance of GTSE1 across > 10,000 subjects representing 33 cancer types based on the cancer genome atlas databases. The expression of GTSE1 was upregulated in almost all cancer types and hyperactivity of GTSE1 is likely to induce DNA repair response and positively correlates with the tumor mutational burden and microsatellite instability which are both promising predictive biomarkers for immunotherapy. GTSE1 was upregulated in TP53 mutation patients. Additionally, GTSE1 also positively correlates with tumor purity and tumor infiltration of immune-suppressive myeloid-derived suppressor cells. Consistently, high expression of GTSE1 is associated with poor patient survival in many cancer types. Conclusion: Our study provides new insights into the diagnostic and prognostic role of GTSE1 in cancers and suggests therapeutic approaches for GTSE1-overexpressing cancers by targeting DNA repair response, and the tumor immune microenvironment.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Pan-cancer analyses reveal GTSE1 as a biomarker for the immunosuppressive tumor microenvironment
- Date Crossref
- 25/08/2023
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Jiangsu University Department of Gastroenterology pays non établi dans la noticeUniversité ou école supérieure
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Affiliated Hospital of Jiangsu University pays non établi dans la noticeÉtablissement de santé
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Yangzhou University Department of Clinical Medicine pays non établi dans la noticeUniversité ou école supérieure
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Washington University in St. Louis pays non établi dans la noticeUniversité ou école supérieure
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All data were obtained from public database (TCGA pays non établi dans la noticeInstitution
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The datasets generated during and/or analyzed during the current study are publicly available pays non établi dans la noticeInstitution
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Washington University School of Medicine Department of Cell Biology and Physiology pays non établi dans la noticeUniversité ou école supérieure
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102:34(e34996) pays non établi dans la noticeInstitution
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Kong L Fang Z pays non établi dans la noticeOrganisation à but non lucratif
Department of Gastroenterology — Jiangsu University, Affiliated Hospital of Jiangsu University et Department of Clinical Medicine — Yangzhou University, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.