Expert Guidance on Cognitive Impairment in Alzheimer's Disease: A Practical Seven-Step Approach from the United Arab Emirates
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Le résumé fourni par la source
INTRODUCTION: Cognitive impairment (CI) spans a spectrum from mild CI to severe dementia, with Alzheimer's disease (AD) the most prevalent cause of CI and dementia. Although dementia burden and prevalence in Arab countries reflect general global trends, the United Arab Emirates (UAE) differs from Western countries both culturally and regarding management resources. Further guidance is therefore needed for the diagnosis and management of CI in the UAE. METHODS: A task force of eight neurologists and two non-voting collaborators with special dementia expertise was convened to develop evidence-based position statements/recommendations to guide the diagnosis and management of AD, including the use of amyloid-targeting therapies (ATTs), in the UAE clinical setting. A modified Delphi survey method was chosen to obtain a consensus, ensuring that drafted expert statements reflected diverse perspectives and experiences. Discordance was predefined as > 25% of panelists rating an expert statement as ≤ 3 on the Likert scale. Consensus was predefined as a median rating ≥ 7 without discordance. Expert statements achieving consensus were adopted. RESULTS: A seven-step framework for diagnosing and managing CI in the UAE was developed, with consensus achieved on all statements. Recommendations largely aligned with international guidelines on AD dementia management and treatment, combined with UAE-specific guidance. The framework spans the full patient journey from initial symptoms to diagnosis (including biomarker use), initial treatment (including ATTs where appropriate), and subsequent monitoring and management as the disease progresses. CONCLUSIONS: Management of CI and dementia in UAE requires consideration of international guidelines in the context of regional and local cultural sensitivities and healthcare resources. A holistic approach is recommended, combining appropriate pharmacological treatment with lifestyle interventions, education, and support for patients and care partners. Patients require ongoing monitoring to ensure the approach is tailored to the disease stage and provides optimal quality of life and reduced burden for patients and care partners.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Expert Guidance on Cognitive Impairment in Alzheimer's Disease: A Practical Seven-Step Approach from the United Arab Emirates
- Date Crossref
- 04/10/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Emirates Foundation pays non établi dans la noticeInstitution
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Rashid Hospital pays non établi dans la noticeÉtablissement de santé
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Shaikh Khalifa Medical City pays non établi dans la noticeÉtablissement de santé
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Sheikh Shakhbout Medical City pays non établi dans la noticeÉtablissement de santé
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Oasis Hospital pays non établi dans la noticeÉtablissement de santé
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Dubai Hospital pays non établi dans la noticeÉtablissement de santé
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American Center of Psychiatry & Neurology pays non établi dans la noticeInstitution
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Sheikh Tahnoon Medical City pays non établi dans la noticeInstitution
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Qassimi Hospital pays non établi dans la noticeÉtablissement de santé
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Eli Lilly pays non établi dans la noticeInstitution
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Fakeeh University Hospital pays non établi dans la noticeUniversité ou école supérieure
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Re:cognition Health pays non établi dans la noticeInstitution
Emirates Foundation, Rashid Hospital et Shaikh Khalifa Medical City, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.