Giacomo Di Matteo

From Circuits to Symphonies: A Systems‐Engineering Blueprint for Multimicrobial Synthetic Biology

Miguel Fernández‐Niño, Ludger A. Wessjohann, José Manuel Guillamón, Daniela Burgos-Toro et autres

Synthetic biology is expanding from single-species engineering toward the design of synthetic microbial consortia capable of distributed metabolism, coordinated behavior, and enhanced functional robustness. However, engineering frameworks derived from intracellular genetic circuits remain insufficient to capture the ecological, temporal, and spatial dynamics …

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Harmonized 1 H NMR Workflow Enables Quantitative Betaine Determination from Nontargeted Metabolite Profiling Using Internal and External Standards

Biagia Musio, Maria Trisolini, Rosa Ragone, Stefano Todisco et autres

High Resolution Image Download MS PowerPoint Slide Nontargeted metabolite profiling prioritizes robust comparisons of the analytical outcomes rather than absolute concentration measurement. In this work, it is shown that a harmonized 1D 1 H NMR workflow, originally adopted for nontargeted NMR analysis, …

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Editorial: In vitro digestion in the study of food

Giacomo Di Matteo, Alessandra Cimbalo, Massimo Frangiamone

In vitro digestion models are widely used to study how foods and pharmaceuticals behave along the gastrointestinal tract. Although human nutrition studies remain the gold standard, simulated digestion is faster, cheaper, less labor-intensive and free of ethical constraints, enabling parallel screening and …

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Editorial overview of special issue ‘VSI: Miniaturized spectroscopy’

Giacomo Di Matteo, Silvia Grassi

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Less Is More: A Physiological Dose of Vitamin B12 Enhances Neural Recovery Compared to a High Dose in an H₂O₂-Stressed SH-SY5Y Neural-Like Cell Model

Aimee Rachel Mathew, Luca Buccini, Anacleto Proietti, Giacomo Di Matteo et autres

Abstract Vitamin B12 (VitB12) plays a crucial role in neural homeostasis, and a high dose is preferred as treatment to support recovery from neural impairments. However, a significant knowledge gap remains regarding its dose-dependent effects, particularly in its influence on cellular recovery …

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From Circuits to Symphonies: Redefining Synthetic Biology for Multimicrobial Systems

Miguel Fernández‐Niño, Ludger A. Wessjohann, José Manuel Guillamón, Daniela Burgos-Toro et autres

Synthetic biology is undergoing a pivotal shift from single-species engineering to rational design of synthetic microbial consortia, enabling more complex, efficient, and resilient functionalities. This transition responds to the growing demand for microbial assemblies with synchronized behavior, division of labor, and ecological …

Phytochemical profiling and anti-inflammatory activity of Gentiana lutea roots from Pollino National Park

Giuseppe Falcone, Giacomo Di Matteo, Luisa Mannina, Francesco Cellini et autres

ETHNOPHARMACOLOGICAL RELEVANCE: Gentiana lutea L. is a mountain herb with a long-standing use in traditional European medicine, especially for digestive disorders and for its antiseptic and anti-inflammatory properties. Its roots are also traditionally used in the preparation of regional liqueurs, particularly in …

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The protective effect of Gentiana lutea flower against mycotoxin toxicity in a gastrointestinal barrier in vitro model

Giacomo Di Matteo, Massimo Frangiamone, Pilar Vila Donat, Valter Di Cecco et autres

Objective We investigated the phytochemical composition, gastrointestinal bioaccessibility, and protective effects against mycotoxin-induced toxicity of Gentiana lutea L. flower, a botanical species traditionally used in European herbal medicine. Methods Gentiana lutea flower samples were collected from the Majella National Park and chemically …

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Enhancing Human Health Through Nutrient and Bioactive Compound Recovery from Agri-Food By-Products: A Decade of Progress

Cinzia Ingallina, Mattia Spano, Sabrina Antonia Prencipe, Giuliana Vinci et autres

In light of pressing global nutritional needs, the valorization of agri-food waste constitutes a vital strategy for enhancing human health and nutrition, while simultaneously supporting planetary health. This integrated approach is increasingly indispensable within sustainable and equitable food systems. Recently, a sustainability-driven …

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Current applications of benchtop FT-NMR in food science: From quality control to adulteration detection

Giacomo Di Matteo, Silvia Grassi, Maria Carmela Emanuele, Giuseppe Antonio Scioli et autres

H resonance frequency from 43 MHz to 100 MHz), characterized by compact design, ease of use, and low maintenance costs. As in the case of high-field NMR instruments, benchtop NMR spectra (obtained by Fourier transformation) contain important information useful for compound identification …

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Evaluation of the Phenolic Components, Fiber Content, Antioxidant Activity, and Prebiotic Capacity of a Shortbread Cookie Fortified with Hazelnut Skin Waste

Lara Costantini, Giacomo Di Matteo, Martina Felli, Daniel V. Savatin et autres

Food reformulation is a strategy to make healthier foods by using food waste matrices that are still nutritionally valid. A shortbread cookie was reformulated replacing hazelnut skin (HS) of the Tonda Gentile Romana variety (5% and 10%) to refined flour and proportionally …

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NMR Metabolite Profiling and Antioxidant Properties of Spartan, Jewels, Misty, and Camelia Blueberries

Mattia Spano, Giacomo Di Matteo, Simone Carradori, Marcello Locatelli et autres

The health-promoting properties of blueberries are widely recognized and are mainly attributed to anthocyanins. However, fruit’s chemical composition includes also other components and strongly depends on varieties and climatic conditions. Here, 1 H NMR metabolite profiling and biological activity of four blueberry …

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