Myles Mc Laughlin

Initial Experience with Pseudomonopolar Local Field Potentials in Deep Brain Stimulation for Parkinson's Disease

Loes Laurijssen, Mathijs Meersman, Wim Vandenberghe, Myles Mc Laughlin et autres

BACKGROUND: Local field potentials (LFPs) can assist DBS contact selection in Parkinson's disease (PD). To overcome the spatial uncertainty of bipolar recordings, pseudomonopolar recordings with an onboard algorithm have recently been introduced. OBJECTIVE: To report initial experience with pseudomonopolar recordings. METHODS: Pseudomonopolar …

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Pinpointing obsessive-compulsive symptom severity: Assessing hypersensitivity for symptom-eliciting visual cues using (frequency-tagging) EEG, eye tracking and physiological stress measures

Bart Boets, Laura Luyten, Xena Serifova, Stephanie Van der Donck et autres

In the present project, we will combine frequency-tagging EEG (FT-EEG) with newly designed symptom provocation techniques to investigate the neural sensitivity of OCD patients to symptom-provoking visual OCD-specific stimuli in a fast and objective manner. Using this method, we aim to objectively …

PA01:ONS_passive_avoidance

Boateng Asamoah, Myles Mc Laughlin, Laura Luyten

Temporal patterning of trigeminal nerve stimulation gates hippocampal plasticity across species

Liyi Chen, Qiang Sun, Xinxia Guo, Hemmings Wu et autres

Abstract Non-invasive neuromodulation can influence memory, but whether peripheral stimulation can engage hippocampal plasticity through a defined mechanism and translate across species remains unclear. Here we provide, to our knowledge, the first cross-species evidence linking trigeminal nerve stimulation to sustained hippocampal plasticity, …

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Parameter specific modulation of neuronal firing and extracellular action potential dynamics by transcranial focused ultrasound stimulation in rat motor cortex

Haorun Huang, Charlotte Smets, Liyi Chen, Myles Mc Laughlin

BACKGROUND: Transcranial focused ultrasound stimulation (TUS) has emerged as a promising tool for noninvasive neuromodulation. However, the specific effects of stimulation parameters on neural activity remain incompletely understood. OBJECTIVE: This study investigates how variations in TUS pulse repetition frequency (PRF) and pulse …

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Does Anodal Transcranial Direct Current Stimulation Over the Primary Motor Cortex Really Enhance Motor Sequence Learning?

Silke Kerstens, Luuk van Boekholdt, Hans Vanderheyden, Louise De Smedt et autres

Background: Transcranial direct current stimulation (tDCS) has traditionally been assumed to modulate the brain by directly polarizing cortical neurons. However, recent work has suggested that the resulting electric field reaching the cortex is weak, whereas the field in the scalp is strong …

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Hippocampal rhythm modulation via frequency-tuned trigeminal nerve stimulation

Liyi Chen, Alireza Majdi, Boateng Asamoah, Myles Mc Laughlin

Trigeminal nerve stimulation (TNS) is a non-invasive method for modulating brain activity through peripheral afferent pathways. Although pulse-based stimulation has been commonly used, the impact of sinusoidal alternating current stimulation of the trigeminal nerve (TN-ACS) on hippocampal network activity remains unclear. This …

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From cranium to brain: Rethinking tES neuromodulation through the peripheral pathways

Alireza Majdi, Liyi Chen, Sven Vanneste, Myles Mc Laughlin

Transcranial electrical stimulation (tES) is traditionally framed as a purely cortical intervention, and weak direct or alternating currents delivered through scalp electrodes are assumed to modulate excitability or entrain oscillations directly under electrodes. However, a growing body of evidence suggests that this …

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Open-source, low-cost miniaturized ultrasound transducer for neuromodulation in rodents

Charlotte Smets, Robrecht Pieters, Jyh‐Jang Sun, Myles Mc Laughlin

Low-intensity transcranial ultrasound stimulation (TUS) is an emerging, non-invasive neuromodulation method distinguished by its ability to deliver energy to deep brain areas with high spatial resolution[1]. Therefore, interest in TUS is rapidly growing with many studies investigating potential applications. However, inconsistent results …

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Epicranial electrical stimulation improves non-navigational spatial memory in macaque monkeys

Noa Peeleman, Myles Mc Laughlin, Tom Theys, Mathieu Vandenbulcke et autres

Background: The hippocampus and medial temporal lobe are crucial for spatial memory, and their dysfunction is linked to Alzheimer's disease (AD), with changes detectable even in preclinical stages. Recently, neuromodulation has gained interest as a potential treatment due to its beneficial effects …

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Neural mechanisms of tDCS: Insights from an in-vivo rodent model across a range of electric field strengths

Liyi Chen, Alireza Majdi, Boateng Asamoah, Myles Mc Laughlin

BACKGROUND: Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique that uses low-amplitude currents to generate low electric fields in the brain, influencing cognition, motor skills, and behavior. Despite its potential, the neural mechanisms underlying tDCS remain unclear, in part because …

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Epicranial electrical stimulation improves non-navigational spatial memory in macaque monkeys

Noa Peeleman, Myles Mc Laughlin, Tom Theys, Mathieu Vandenbulcke et autres

Abstract Background The hippocampus and medial temporal lobe are crucial for spatial memory, and their dysfunction is linked to Alzheimer’s disease (AD), with changes detectable even in preclinical stages. Recently, neuromodulation has gained interest as a potential treatment due to its beneficial …

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