Silke Kerstens

No effect of anodal high-definition transcranial direct current stimulation during motor sequence learning in older people

Silke Kerstens, Sanne Broeder, Moran Gilat, Evelien Nackaerts et autres

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Does Anodal Transcranial Direct Current Stimulation Over the Primary Motor Cortex Really Enhance Motor Sequence Learning?

Silke Kerstens, Luuk van Boekholdt, Hans Vanderheyden, Louise De Smedt et autres

Background: Transcranial direct current stimulation (tDCS) has traditionally been assumed to modulate the brain by directly polarizing cortical neurons. However, recent work has suggested that the resulting electric field reaching the cortex is weak, whereas the field in the scalp is strong …

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Does anodal tDCS over M1 really enhance motor sequence learning? A non-replication of earlier findings in a double-blind, pre-registered large-sample study in humans

Silke Kerstens, Luuk van Boekholdt, Hans Vanderheyden, Louise De Smedt et autres

Background: Transcranial direct current stimulation (tDCS) is one of the most widely used noninvasive neuromodulation methods. Despite its popularity, some recent studies highlighted issues about the reproducibility of earlier reported tDCS results. Until recently, it was assumed that tDCS elicits its neuromodulatory …

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tDCS peripheral nerve stimulation can enhance passive avoidance learning in rats

Luuk van Boekholdt, Silke Kerstens, Kaydee Decloedt, Myles Mc Laughlin

Transcranial direct current stimulation (tDCS) is being considered as a treatment for many psychiatric and neurological disorders. Rodent models of tDCS have been used in several behavioral tasks to demonstrate the technique's benefits in improving memory and learning. Recent research suggests that …

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3D-printable stimulation electrodes to improve precision, reproducibility, and reliability of transcranial electric current stimulation

Silke Kerstens, Luuk van Boekholdt, Jean‐Jacques Orban de Xivry, Myles Mc Laughlin

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External stimulation of the trigeminal nerve causes pupil dilation in healthy volunteers, suggesting locus coeruleus modulation

Nina Seminck, Ahmad Khatoun, Silke Kerstens, Bart Nuttin et autres

External trigeminal nerve stimulation (eTNS) is a non-invasive neuromodulation method that delivers electrical current via patch electrodes on the forehead, cheek or jaw to target a branch of the trigeminal nerve. eTNS has proven effective for treating migraines [1], trigeminal neuralgia [2] …

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A novel free-moving rat model of transcranial direct current stimulation

Luuk van Boekholdt, Silke Kerstens, Myles Mc Laughlin

Despite the popularity of transcranial direct current stimulation (tDCS), we still do not know how this neuromodulation method exerts many of its effects. Animal models of tDCS are used to emulate human tDCS with the aim of investigating the technique's effects and …

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A novel tDCS control condition using optimized anesthetic gel to block peripheral nerve input

Silke Kerstens, Jean‐Jacques Orban de Xivry, Myles Mc Laughlin

Background Recent studies indicate that some transcranial direct current stimulation (tDCS) effects may be caused by indirect stimulation of peripheral nerves in the scalp rather than the electric field in the brain. To address this, we developed a novel tDCS control condition …

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A rat model to understand tDCS mechanistic underpinnings

Luuk van Boekholdt, Silke Kerstens, Boateng Asamoah, Ahmad Khatoun et autres

Objectives: We consider two consequences of brain capillary ultra-structure in neuromodulation.First, blood-brain-barrier (BBB) polarization as a consequence of current crossing between interstitial space and the blood.Second, interstitial current flow distortion around capillaries impacting neuronal stimulation. Materials and Methods:We developed computational models of …

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Development of novel tDCS stimulation condition to investigate tDCS neurophysiological mechanisms

Silke Kerstens, Luuk van Boekholdt, Nina Seminck, Boateng Asamoah et autres

anterior to M1 at an interstimulus interval (ISI) of 6 ms and an intensity of 75% of the resting motor threshold (rMT).To physiologically test this setup, short-interval intra-cortical inhibition (SICI) was measured with the same coil arrangement, using two coils targeted at …

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tDCS peripheral nerve stimulation: a neglected mode of action?

Luuk van Boekholdt, Silke Kerstens, Ahmad Khatoun, Boateng Asamoah et autres

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