Steffen Hennig

Chronic inflammatory demyelinating polyneuropathy (CIDP) after cilta-cel therapy

Michael Korenkov, Julian Liebaert, Schayan Yousefian, Stefan Schwartz et autres

Ciltacabtagene-autoleucel (cilta-cel) is a CAR-T cell therapy highly active in relapsed/refractory multiple myeloma but can induce severe immune-mediated toxicities. We describe two patients who developed chronic inflammatory demyelinating polyneuropathy (CIDP) after cilta-cel. Patient 1 presented with rapidly progressive gait ataxia, flaccid paraparesis, …

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A new clustering approach identifies tumor-specific common TCRs with pan-cancer reactivity

Steffen Hennig, Kristin Gennermann, Sefer Elezkurtaj, Volkhard Seitz et autres

Abstract Tumor-specific T-cells are key in combating cancer as shown in adoptive cell therapy with tumor infiltrating lymphocytes (TILs) and checkpoint inhibitor therapy. Studies in many types of cancer have shown that preexisting tumor reactive T-cells are not only tumor-but typically also …

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T-cell receptors identified by a personalized antigen-agnostic screening approach target shared neoantigen KRAS Q61H

Volker Lennerz, Christoph Doppler, Martina Fatho, Anja Dröge et autres

Adoptive cell therapy (ACT) with TCR-engineered T-cells represents a promising alternative to TIL- or CAR-T therapies for patients with advanced solid cancers. Currently, selection of therapeutic TCRs critically depends on knowing the target antigens, a condition excluding most patients from treatment. Direct …

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T-cell receptors identified by a personalized antigen-agnostic screening approach target shared neoantigen KRAS Q61H

Volker Lennerz, Christoph Doppler, Martina Fatho, Anja Droege et autres

Abstract Adoptive cell therapy (ACT) with TCR-engineered T-cells represents a promising alternative to TIL- or CAR-T therapies for patients with advanced solid cancers. Currently, selection of therapeutic TCRs critically depends on knowing the target antigens, a condition excluding most patients from treatment. …

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Specific T-cell receptor beta-rearrangements of gluten-triggered CD8+ T-cells are enriched in celiac disease patients' duodenal mucosa

Volkhard Seitz, Kristin Gennermann, Sefer Elezkurtaj, Detlef Groth et autres

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Optimised protocols for RNA extraction from a broad taxonomic range of algae

T. E. Jensen, Livia Saleh, Dominik Bents, Steffen Krohn et autres

Abstract Despite advancements in RNA extraction methods, RNA extraction from sources rich in polyphenols and polysaccharides such as algae and seagrasses remains a challenge. Here we present a RNA extraction strategy using a hexadecyltrimethylammonium bromide (CTAB) extraction buffer and demonstrate its effectiveness …

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Reconstitution of EBV-directed T cell immunity by adoptive transfer of peptide-stimulated T cells in a patient after allogeneic stem cell transplantation for AITL

María Fernanda Lammoglia Cobo, Julia M. Ritter, Regina Gary, Volkhard Seitz et autres

Reconstitution of the T cell repertoire after allogeneic stem cell transplantation is a long and often incomplete process. As a result, reactivation of Epstein-Barr virus (EBV) is a frequent complication that may be treated by adoptive transfer of donor-derived EBV-specific T cells. …

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Treatment with ribociclib shows favourable immunomodulatory effects in patients with hormone receptor-positive breast cancer—findings from the RIBECCA trial

Caroline Anna Peuker, Sarvenaz Yaghobramzi, Corinna Grunert, Luisa Keilholz et autres

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Reconstitution of T cell immunity against EBV in the immunocompromised host by adoptive transfer of peptide-stimulated T cells after allogeneic stem cell transplantation

María Fernanda Lammoglia Cobo, Julia M. Ritter, Regina Gary, Volkhard Seitz et autres

Abstract Reconstitution of T cell repertoire after allogeneic stem cell transplantation is a long and often incomplete process. As a result, reactivation of Epstein-Barr virus (EBV) is a frequent complication that may be treated by adoptive transfer of donor-derived EBV-specific T cells. …

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Evidence for a role of RUNX1 as recombinase cofactor for TCRβ rearrangements and pathological deletions in ETV6-RUNX1 ALL

Volkhard Seitz, Karsten Kleo, Anja Dröge, Sigrid Schaper et autres

Abstract T-cell receptor gene beta (TCRβ) gene rearrangement represents a complex, tightly regulated molecular mechanism involving excision, deletion and recombination of DNA during T-cell development. RUNX1, a well-known transcription factor for T-cell differentiation, has recently been described to act in addition as …

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Small-Molecule Intervention At The Dimerization Interface Of Survivin By Novel Rigidized Scaffolds

Ibrahim TM, C. Ernst, Andreas Lange, Steffen Hennig et autres

Tamer M Ibrahim,1,2 Christoph Ernst,1 Andreas Lange,1 Susanne Hennig,1 Frank M Boeckler1 1Laboratory for Molecular Design and Pharmaceutical Biophysics, Department of Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy, Eberhard Karls University Tübingen, Tübingen, Germany; 2Pharmaceutical Chemistry Department, Faculty of Pharmacy, Kafrelsheikh University, …

Tumorreaktive T-Zellen als Therapiemöglichkeit beim Lungenkarzinom

Maria Schimek, Steffen Hennig, V Seitz, Ernst Späth‐Schwalbe et autres

Hintergrund: Ein innovatives Therapiekonzept für das Lungenkarzinom besteht darin, körpereigene T-Zellen mit tumorreaktiven T-Zellrezeptoren zu isolieren, zu vermehren und schließlich zu transferieren. Durch die Bindung an das tumorspezifische Antigen wird die körpereigene Immunantwort gegen den Tumor initiiert, die dann zu einer Regression …

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