I‐Neng Lee

Elevated expression and secretion of TGF-α contribute to Temozolomide resistance in human glioblastoma cells

Jen‐Tsung Yang, I‐Neng Lee, Ming-Shan Chen, Cheng Huang et autres

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor often treated with Temozolomide (TMZ). Research reveals that secretory substances and receptor-activated signaling may contribute to TMZ resistance in GBM cells. RNA-Seq and bioinformatics analyses reveal that TMZ treatment downregulates most genes, particularly …

tw (code pays fourni par la source)

Enhanced versus standard hydration in acute ischemic stroke: REVIVE—A randomized clinical trial

Leng Chieh Lin, Tsong‐Hai Lee, Yen-Chu Huang, Yuan Hsiung Tsai et autres

RATIONALE: Early neurological deterioration (END) within 72 h of stroke onset is associated with poor prognosis. Optimizing hydration might reduce the risk of END. AIMS: This study aimed to determine in acute ischemic stroke patients if enhanced hydration versus standard hydration reduced …

tw, gb, au (code pays fourni par la source)

ADAM17 Confers Temozolomide Resistance in Human Glioblastoma Cells and miR-145 Regulates Its Expression

Jen‐Tsung Yang, I‐Neng Lee, Cheng Huang, Hsiu‐Chen Huang et autres

Glioblastoma (GBM) is a malignant brain tumor, commonly treated with temozolomide (TMZ). Upregulation of A disintegrin and metalloproteinases (ADAMs) is correlated to malignancy; however, whether ADAMs modulate TMZ sensitivity in GBM cells remains unclear. To explore the role of ADAMs in TMZ …

tw (code pays fourni par la source)

Gallic Acid Enhances the Anti-Cancer Effect of Temozolomide in Human Glioma Cell Line via Inhibition of Akt and p38-MAPK Pathway

Jen‐Tsung Yang, I‐Neng Lee, Chun‐Han Chen, Fung-Jou Lu et autres

(1) Background: Temozolomide (TMZ), an oral alkylating agent, is used to treat malignant gliomas and other difficult-to-treat tumors. TMZ can enter the cerebrospinal fluid p.o. (per os) and does not need hepatic metabolism for activation of its use as a standard chemotherapeutic …

tw (code pays fourni par la source)

Propofol induces apoptosis and ameliorates 5‑fluorouracil resistance in OSCC cells by reducing the expression and secretion of amphiregulin

Kung-Ssu Yang, Pi-Cheng Che, Ming‐Ju Hsieh, I‐Neng Lee et autres

Among the different types of oral cancer, >90% of cases are oral squamous cell carcinoma (OSCC). 5‑fluorouracil (5‑FU) is a commonly used treatment for OSCC, but cells typically display resistance to the drug. Propofol, an intravenous anesthetic agent, exhibits certain anticancer effects, …

tw (code pays fourni par la source)

Elevated XRCC5 expression level can promote temozolomide resistance and predict poor prognosis in glioblastoma

I‐Neng Lee, Jen‐Tsung Yang, Cheng Huang, Hsiu‐Chen Huang et autres

Drug resistance and disease recurrence are important contributors for the poor prognosis of glioblastoma multiforme (GBM). Temozolomide (TMZ), the standard chemotherapy for GBM treatment, can methylate DNA and cause the formation of double‑strand breaks (DSBs). X‑ray repair cross complementing 5 (XRCC5), also …

tw (code pays fourni par la source)

Effects of Early Rehydration on Brain Perfusion and Infarct Core after Middle Cerebral Artery Occlusion in Rats

Yuan‐Hsiung Tsai, Chia‐Hao Su, I‐Neng Lee, Jen‐Tsung Yang et autres

Imaging evidence for the effect of rehydration on cerebral perfusion and brain ischemia has never been proposed in the literature. This study aimed to test the hypothesis that early rehydration treatment can improve cerebral perfusion and decrease infarct volume, consequently reducing mortality …

tw (code pays fourni par la source)

Knockdown of Amphiregulin Triggers Doxorubicin-Induced Autophagic and Apoptotic Death by Regulating Endoplasmic Reticulum Stress in Glioblastoma Cells

I‐Neng Lee, Jen‐Tsung Yang, Ming‐Ju Hsieh, Cheng Huang et autres

tw (code pays fourni par la source)

Basic fibroblast growth factor promotes doxorubicin resistance in chondrosarcoma cells by affecting XRCC5 expression

Ming‐Ju Hsieh, Cheng Huang, Chia‐Chieh Lin, Chih‐Hsin Tang et autres

Chondrosarcoma is the second most common form of bone cancer and is characterized by its ability to produce an extracellular matrix of the cartilage. High-grade chondrosarcoma is highly aggressive and can metastasize to other parts of the body. Chondrosarcoma is resistant to …

tw (code pays fourni par la source)

A Portable System to Monitor Saliva Conductivity for Dehydration Diagnosis and Kidney Healthcare

Yen-Pei Lu, Jo-Wen Huang, I‐Neng Lee, Rui-Cian Weng et autres

Chronic kidney disease (CKD) has become a major issue in long-term healthcare. It is caused by recurrent kidney injury, which is possible induced by dehydration and heat stress. Therefore, it is important to access the dehydration diagnosis on fields. Conventional instruments for …

tw (code pays fourni par la source)

Secreted amphiregulin promotes vincristine resistance in oral squamous cell carcinoma

Ming‐Ju Hsieh, Yin‐Hong Chen, I‐Neng Lee, Cheng Huang et autres

Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer. Despite advances in surgery, radiotherapy and chemotherapy, the overall 5‑year survival rate of patients with OSCC has not significantly improved. In addition, the prognosis of patients with advanced‑stage OSCC …

tw (code pays fourni par la source)

Valproic acid-induced amphiregulin secretion confers resistance to temozolomide treatment in human glioma cells

Jui‐Chieh Chen, I‐Neng Lee, Cheng Huang, Yuping Wu et autres

BACKGROUND: Glioblastoma multiforme (GBM) is the most severe type of primary brain tumor with a high mortality rate. Although extensive treatments for GBM, including resection, irradiation, chemotherapy and immunotherapy, have been tried, the prognosis is still poor. Temozolomide (TMZ), an alkylating agent, …

tw (code pays fourni par la source)