Jui‐Chieh Chen

Cross-Species Identification of Urinary Small Extracellular Vesicle-Associated miR-223-3p as a Candidate Biomarker for Nephrolithiasis in a Discovery Cohort

Bo‐Jung Chen, Jang Jeong Uk, Cheng‐Huang Shen, Chiung‐Yao Fang et autres

Background: Nephrolithiasis remains a major global health burden with limited non-invasive tools for early diagnosis and monitoring.Urinary small extracellular vesicle (sEV)-associated microRNAs (miRNAs) are stable molecular signatures that reflect renal pathophysiological shifts.This study aims to identify candidate urinary sEV-associated miRNAs for nephrolithiasis …

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Elevated expression and secretion of TGF-α contribute to Temozolomide resistance in human glioblastoma cells

Jen‐Tsung Yang, I‐Neng Lee, Ming-Shan Chen, Cheng Huang et autres

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor often treated with Temozolomide (TMZ). Research reveals that secretory substances and receptor-activated signaling may contribute to TMZ resistance in GBM cells. RNA-Seq and bioinformatics analyses reveal that TMZ treatment downregulates most genes, particularly …

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Ugonin L ameliorates pulmonary fibrosis as a novel TβRs inhibitor by regulating the TGF-β/TβRs signaling and autophagy

Tzu-Lan Hsia, Wei-Chung Chiou, Hsiu‐Chen Huang, Hui‐Kang Liu et autres

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrotic lung disease of unknown etiology, affecting about 3 million individuals worldwide. Significant risk factors for IPF include advanced age and infectious agents. Current FDA-approved antifibrotic drugs slow the progression of pulmonary fibrosis with …

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Characterizing the gut microbiota composition in Taiwanese hypertensive patients using 16S rRNA sequencing analysis

Ming‐Shan Chen, Shin-Kuang Jiang, Zhi-Yong Chong, Jou-Wei Chiang et autres

Hypertension (HTN) is a significant risk factor for cardiovascular and cerebrovascular diseases.Accumulating evidence suggests a close relationship between HTN and alterations in the gut microbiota composition and abundance.We recruited 23 HTN patients and 17 controls matched for demographic characteristics.DNA extracted from fecal …

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Transcriptomic data integration and analysis revealing potential mechanisms of doxorubicin resistance in chondrosarcoma cells

Jui‐Chieh Chen, Ming‐Shan Chen, Shin-Kuang Jiang, Chi-Yang Eaw et autres

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Lidocaine attenuates TMZ resistance and inhibits cell migration by modulating the MET pathway in glioblastoma cells

Ming‐Shan Chen, Zhi-Yong Chong, Cheng Huang, Hsiu‐Chen Huang et autres

Glioblastoma multiforme (GBM) is the most aggressive type of malignant brain tumor. Currently, the predominant clinical treatment is the combination of surgical resection with concurrent radiotherapy and chemotherapy, using temozolomide (TMZ) as the primary chemotherapy drug. Lidocaine, a widely used amide‑based local …

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Modulation of secretory factors by lipofundin contributes to its anti‑neuroinflammatory effects

Ming‐Shan Chen, Chia-Lin Hu, Shin-Kuang Jiang, Zhi-Yong Chong et autres

As the global population ages, the prevalence of neuroinflammatory diseases such as Alzheimer's disease, Parkinson's disease and stroke continues to increase.Therefore, it is necessary to develop preventive and therapeutic methods against neuroinflammatory diseases.Lipofundin is a lipid emulsion commonly used in clinical anesthetic …

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Transcriptomic Data Integration and Analysis Revealing Potential Mechanisms of Doxorubicin Resistance in Chondrosarcoma Cells

Jui‐Chieh Chen, Ming‐Shan Chen, Shin-Kuang Jiang, Chi-Yang Eaw et autres

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Ergosterol peroxide blocks HDV infection as a novel entry inhibitor by targeting human NTCP receptor

Wei-Chung Chiou, Yi-Syuan Lyu, Tzu-Lan Hsia, Jui‐Chieh Chen et autres

Hepatitis D virus (HDV), which co-infects or superinfects patients with hepatitis B virus, is estimated to affect 74 million people worldwide. Chronic hepatitis D is the most severe form of viral hepatitis and can result in liver cirrhosis, liver failure, and hepatocellular …

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Characterizing the gut microbiota composition in Taiwanese hypertensive patients using 16S rRNA sequencing analysis

Ming‐Shan Chen, Shin-Kuang Jiang, Zhi-Yong Chong, Jou-Wei Chiang et autres

Abstract Objective Hypertension (HTN) is a significant risk factor for cardiovascular and cerebrovascular diseases. Accumulating evidence suggests a close relationship between HTN and dysbiosis of the gut microbiota. Methods In the present study, we recruited 23 HTN patients and 17 controls matched …

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α-Viniferin-Induced Apoptosis through Downregulation of SIRT1 in Non-Small Cell Lung Cancer Cells

Cheng Huang, Zijun Lin, Jui‐Chieh Chen, Haojun Zheng et autres

α-Viniferin, a natural stilbene compound found in plants and a polymer of resveratrol, had demonstrated potential anti-cancer and anti-inflammatory effects. However, the specific mechanisms underlying its anti-cancer activity were not yet fully understood and required further investigation. This study evaluated the effectiveness …

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ADAM17 Confers Temozolomide Resistance in Human Glioblastoma Cells and miR-145 Regulates Its Expression

Jen‐Tsung Yang, I‐Neng Lee, Cheng Huang, Hsiu‐Chen Huang et autres

Glioblastoma (GBM) is a malignant brain tumor, commonly treated with temozolomide (TMZ). Upregulation of A disintegrin and metalloproteinases (ADAMs) is correlated to malignancy; however, whether ADAMs modulate TMZ sensitivity in GBM cells remains unclear. To explore the role of ADAMs in TMZ …

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