Choong‐Hyun Koh

The interplay between lipid metabolism, cancer progression and anti-cancer immunity

Choong‐Hyun Koh, Yoosun Lee, Il‐Kyu Kim, Yeonseok Chung

The tumour microenvironment (TME) consists of a complex ecosystem of tumour cells, stromal elements, extracellular matrix, fibroblasts and diverse immune-cell populations. Although traditional cancer therapies have primarily focused on eliminating tumour cells, subsequent advances highlighted the importance of modulating immune cells within …

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Supplementary Figures from Activation of NKT Cells in an Anti-PD-1–Resistant Tumor Model Enhances Antitumor Immunity by Reinvigorating Exhausted CD8 T Cells

Eun‐Ah Bae, Hyungseok Seo, Byung Seok Kim, Jeongwon Choi et autres

Supplementary Figures

Data from Activation of NKT Cells in an Anti-PD-1–Resistant Tumor Model Enhances Antitumor Immunity by Reinvigorating Exhausted CD8 T Cells

Eun‐Ah Bae, Hyungseok Seo, Byung Seok Kim, Jeongwon Choi et autres

Abstract PD-1–based cancer immunotherapy is a successful example of immune checkpoint blockade that provides long-term durable therapeutic effects in patients with cancer across a wide spectrum of cancer types. Accumulating evidence suggests that anti-PD-1 therapy enhances antitumor immunity by reversing the function …

IL-17 and IL-21: Their Immunobiology and Therapeutic Potentials

Choong‐Hyun Koh, Byung‐Seok Kim, Chang‐Yuil Kang, Yeonseok Chung et autres

Studies over the last 2 decades have identified IL-17 and IL-21 as key cytokines in the modulation of a wide range of immune responses. IL-17 serves as a critical defender against bacterial and fungal pathogens, while maintaining symbiotic relationships with commensal microbiota. …

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CD8 T-cell subsets: heterogeneity, functions, and therapeutic potential

Choong‐Hyun Koh, Suyoung Lee, Minkyeong Kwak, Byung‐Seok Kim et autres

CD8 T cells play crucial roles in immune surveillance and defense against infections and cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire effector functions, enabling them to eliminate infected or malignant cells. Traditionally, cytotoxic T cells, characterized by …

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A Personalized Cancer Vaccine that Induces Synergistic Innate and Adaptive Immune Responses

Da‐Sol Kuen, Jihye Hong, Suyoung Lee, Choong‐Hyun Koh et autres

Abstract To demonstrate potent efficacy, a cancer vaccine needs to activate both innate and adaptive immune cells. Personalized cancer vaccine strategies often require the identification of patient‐specific neoantigens; however, the clonal and mutational heterogeneity of cancer cells presents inherent challenges. Here, extracellular …

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Data from GM-CSF Promotes Antitumor Immunity by Inducing Th9 Cell Responses

Il‐Kyu Kim, Choong‐Hyun Koh, Insu Jeon, Kwangsoo Shin et autres

Abstract GM-CSF as an adjuvant has been shown to promote antitumor immunity in mice and humans; however, the underlying mechanism of GM-CSF–induced antitumor immunity remains incompletely understood. In this study, we demonstrate that GM-CSF potentiates the efficacy of cancer vaccines through IL9-producing …

Data from GM-CSF Promotes Antitumor Immunity by Inducing Th9 Cell Responses

Il‐Kyu Kim, Choong‐Hyun Koh, Insu Jeon, Kwangsoo Shin et autres

Abstract GM-CSF as an adjuvant has been shown to promote antitumor immunity in mice and humans; however, the underlying mechanism of GM-CSF–induced antitumor immunity remains incompletely understood. In this study, we demonstrate that GM-CSF potentiates the efficacy of cancer vaccines through IL9-producing …

Supplementary Figures from GM-CSF Promotes Antitumor Immunity by Inducing Th9 Cell Responses

Il‐Kyu Kim, Choong‐Hyun Koh, Insu Jeon, Kwangsoo Shin et autres

Supplementary Figs. 1-9

Supplementary Figures from GM-CSF Promotes Antitumor Immunity by Inducing Th9 Cell Responses

Il‐Kyu Kim, Choong‐Hyun Koh, Insu Jeon, Kwangsoo Shin et autres

Supplementary Figs. 1-9

Nanovesicle‐Mediated Targeted Delivery of Immune Checkpoint Blockades to Potentiate Therapeutic Efficacy and Prevent Side Effects

Mungyo Jung, Mikyung Kang, Byung‐Seok Kim, Jihye Hong et autres

Despite the clinically proven efficacies of immune checkpoint blockades, including anti-cytotoxic T lymphocyte-associated protein 4 antibody (αCTLA-4), the low response rate and immune-related adverse events (irAEs) in cancer patients represent major drawbacks of the therapy. These drawbacks of αCTLA-4 therapy are mainly …

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Inhibition of topoisomerase I shapes antitumor immunity through the induction of monocyte-derived dendritic cells

Jeong-Mi Lee, Kwangsoo Shin, Choong‐Hyun Koh, Boyeong Song et autres

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