Benno Pütz

Uncovering the impact of co-infections on disease severity and mortality in pulmonary cryptococcosis

Luling Wu, Xuemin Fu, Ling Weng, Benno Pütz et autres

BACKGROUND: Increasing case reports and monocentric studies suggest that co-infections may be associated with poorer outcomes in patients with pulmonary cryptococcosis (PC), including both people living with HIV (PLWH) and HIV-negative individuals. However, systematic cohort-based evidence evaluating the prognostic impact of co-infections …

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Randomized, double-blind, sham-controlled pilot trial of theta-band transcranial alternating current stimulation during cognitive training in mild Alzheimer’s disease

Qian Gong, Xuemin Fu, Daxi Feng, Shuying Rao et autres

Cognitive deficits are a hallmark of Alzheimer's disease (AD), and effective treatments remain elusive. Transcranial alternating current stimulation (tACS), a non-invasive technique, has shown potential in improving cognitive function across various populations, but further research is needed to investigate its efficacy in …

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Predictive survival modelings for HIV-related cryptococcosis: comparing machine learning approaches

Xuemin Fu, Luling Wu, Jingna Xun, Benno Pütz et autres

Introduction: HIV-associated cryptococcosis is marked by unpredictable disease trajectories and persistently high mortality rates worldwide. Although improved risk stratification and tailored clinical management are urgently needed to enhance patient survival, such strategies remain limited. Methods: We analyzed clinical and immunological data from …

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Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

Luis M. García‐Marín, Louis Nicholas Vinke, David C M Liewald, Jingyun Yang et autres

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

Luis M. García‐Marín, Adrián I. Campos, Santiago Díaz‐Torres, Jill A. Rabinowitz et autres

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Extracellular vesicle-mediated trafficking of molecular cues during human brain development

Andrea Carolina Pérez Forero, Fabrizia Pipicelli, Sylvain Moser, Natalia Baumann et autres

Cellular crosstalk is an essential process influenced by numerous factors, including secreted vesicles that transfer nucleic acids, lipids, and proteins between cells. Extracellular vesicles (EVs) have been the center of many studies focusing on neurodegenerative disorders, but whether EVs display cell-type-specific features …

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Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

Luis M. García‐Marín, Adrián I. Campos, Santiago Díaz‐Torres, Jill A. Rabinowitz et autres

Subcortical brain structures are involved in developmental, psychiatric and neurological disorders. We performed GWAS meta-analyses of intracranial and nine subcortical brain volumes (brainstem, caudate nucleus, putamen, hippocampus, globus pallidus, thalamus, nucleus accumbens, amygdala and, for the first time, the ventral diencephalon) in …

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Correction: Comprehensive risk factor predictions for 3-year survival among HIV-associated and disseminated cryptococcosis involving lungs and central nervous system

Luling Wu, Xuemin Fu, Benno Pütz, Renfang Zhang et autres

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Comprehensive risk factor predictions for 3-year survival among HIV-associated and disseminated cryptococcosis involving lungs and central nervous system

Luling Wu, Xuemin Fu, Benno Pütz, Renfang Zhang et autres

BACKGROUND: The global mortality rate resulting from HIV-associated cryptococcal disease is remarkably elevated, particularly in severe cases with dissemination to the lungs and central nervous system (CNS). Regrettably, there is a dearth of predictive analysis regarding long-term survival, and few studies have …

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Automatically annotated motion tracking identifies a distinct social behavioral profile following chronic social defeat stress

Joeri Bordes, Lucas Miranda, Maya Reinhardt, Sowmya V. Narayan et autres

Severe stress exposure increases the risk of stress-related disorders such as major depressive disorder (MDD). An essential characteristic of MDD is the impairment of social functioning and lack of social motivation. Chronic social defeat stress is an established animal model for MDD …

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Extracellular vesicle-mediated trafficking of developmental cues is altered during human brain disease

Fabrizia Pipicelli, Andrea Forero, Sylvain Moser, Francesco Di Matteo et autres

Abstract Cellular crosstalk is an essential process influenced by numerous factors including secreted vesicles that transfer nucleic acids, lipids, and proteins between cells. Extracellular vesicles (EVs) have been the center of many studies focusing on neuron-to-neuron communication, but the role of EVs …

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DeepOF: a Python package for supervised and unsupervised pattern recognition in mice motion tracking data

Lucas Miranda, Joeri Bordes, Benno Pütz, Mathias V. Schmidt et autres

Miranda et al., (2023). DeepOF: a Python package for supervised and unsupervised pattern recognition in mice motion tracking data. Journal of Open Source Software, 8(86), 5394, https://doi.org/10.21105/joss.05394

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