Randomized, double-blind, sham-controlled pilot trial of theta-band transcranial alternating current stimulation during cognitive training in mild Alzheimer’s disease
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Le résumé fourni par la source
Cognitive deficits are a hallmark of Alzheimer's disease (AD), and effective treatments remain elusive. Transcranial alternating current stimulation (tACS), a non-invasive technique, has shown potential in improving cognitive function across various populations, but further research is needed to investigate its efficacy in AD. In a randomized, double-blind, sham-controlled pilot trial, 36 mild AD patients received active or sham theta-tACS (8 Hz, 1.6 mA, 20-min daily) during n-back task for two weeks, followed by a 10-week follow-up. Cognitive assessments and resting-state EEG were analyzed at baseline, after-treatment, and follow-up. The results showed that the active group demonstrated significant cognitive improvements after treatment (MMSE: t (15) =-3.273, p = 0.005, Cohen's d = 0.82), particularly in short-term memory (MMSE-recall: Z = -2.11, p = 0.035, r = 0.53), with maintained benefits after 10 weeks. In contrast, the sham group exhibited long-term cognitive decline (MMSE: t (4) = 3.586, p = 0.023, Cohen's d = -1.60). EEG analysis revealed reduced gamma power (t (23) = 2.689, p = 0.013, Cohen's d = 1.077) and theta connectivity in active group, particularly in the frontotemporal regions (F4/F7: t (23) = 2.467, p = 0.021, Cohen's d = 0.988; F4/T3: t (23) = 2.465, p = 0.022, Cohen's d = 0.987), which was correlated with cognitive improvements (R = -0.57, p = 0.043). In conclusion, tACS combining cognitive training may offer cognitive benefits in mild AD by modulating neural activity, though further studies are needed to clarify its mechanisms.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Randomized, double-blind, sham-controlled pilot trial of theta-band transcranial alternating current stimulation during cognitive training in mild Alzheimer’s disease
- Date Crossref
- 31/01/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sir Run Run Shaw Hospital pays non établi dans la noticeÉtablissement de santé
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Zhejiang University Department of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
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Max Planck Institute of Psychiatry Statistical Genetics pays non établi dans la noticeStructure de recherche
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Zhejiang Lab pays non établi dans la noticeStructure de recherche
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Hangzhou Seventh Peoples Hospital pays non établi dans la noticeStructure de recherche
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Southeast University pays non établi dans la noticeUniversité ou école supérieure
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The First People's Hospital of Wuyi Country Department of Psychiatry pays non établi dans la noticeÉtablissement de santé
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School of Brain Science and Brain Medicine Affiliated Mental Health Center & Hangzhou Seventh People's Hospital pays non établi dans la noticeUniversité ou école supérieure
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College of Biomedical Engineering & Instrument Science pays non établi dans la noticeUniversité ou école supérieure
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Key Laboratory of Clinical and Basic Research on Mental Diseases of Zhejiang Province pays non établi dans la noticeStructure de recherche
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Key Laboratory of Medical Neurobiology of Zhejiang Province pays non établi dans la noticeStructure de recherche
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School of Biological Science and Medical Engineering pays non établi dans la noticeUniversité ou école supérieure
Sir Run Run Shaw Hospital, Department of Psychiatry — Zhejiang University et Statistical Genetics — Max Planck Institute of Psychiatry, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.