Julian Schwarting

A256 Automated nnU-net–based segmentation of intracranial aneurysms and cerebral vessels in 3D rotational angiography for endovascular treatment planning

Julian Schwarting, Chiara Emrich, Hendrik Möller, Jan Kirschke

Background/Introduction Accurate segmentation of intracranial vessels and aneurysms is essential for endovascular treatment planning and device selection. Current segmentation approaches are predominantly based on thresholding techniques, which frequently require manual correction and may yield inaccurate results due to inhomogeneous contrast opacification of …

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Secondary risks of bleeding and associated outcome after tirofiban application during interventional treatment of intracranial aneurysms

Michael Griessmair, Jannis Bodden, Dennis M. Hedderich, Jan Stefan Kirschke et autres

Introduction: Device-assisted endovascular treatment of ruptured aneurysms may require antiplatelet therapy, but bleeding risk is a concern. This retrospective propensity score-matched cohort study investigated whether tirofiban, including prolonged administration for ≥7 days, was associated with secondary bleeding complications. Methods: We analyzed 99 …

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Secondary risks of bleeding and associated outcome after tirofiban application during interventional treatment of intracranial aneurysms.

Michael Griessmair, Jannis Bodden, Dennis Hedderich, Jan Kirschke et autres

Introduction Device-assisted endovascular treatment of ruptured aneurysms may require antiplatelet therapy, but bleeding risk is a concern. This retrospective propensity score-matched cohort study investigated whether tirofiban, including prolonged administration for ≥7 days, was associated with secondary bleeding complications. Methods We analyzed 99 …

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Detection of subarachnoid hemorrhage by bilateral transcranial laser doppler fluxmetry allows long-term studies in mice

Biyan Nathanael Harapan, Julian Schwarting, Andrea Cattaneo, Dilara Ozsavas et autres

BACKGROUND: The murine middle cerebral artery (MCA) perforation model is widely used to study subarachnoid hemorrhage (SAH) but typically requires invasive intracranial pressure (ICP) monitoring to prove successful induction of hemorrhage. However, ICP probe placement causes substantial additional parenchymal damage, confounding long-term …

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A251 Long-term tirofiban administration is not associated with increased surgical risks after treatment of ruptured aneurysms

Julian Schwarting, Michael Griessmair, Jannis H. Bodden, Maria Wostrack et autres

Introduction Thromboembolic complications following complex aneurysm treatments may be prevented by long-term administration of tirofiban. However, due to the potential risk of complications—particularly intraparenchymal hemorrhage—surgical aneurysm occlusion may be preferred in such cases. Aim of study In this retrospective, propensity score-matched cohort …

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Detection of remnants in clipped unruptured intracranial aneurysms by intraoperative CT-angiography and postoperative DSA: clinical relevance and follow-up

Jun Thorsteinsdottir, Julian Schwarting, Robert Forbrig, Sebastian Siller et autres

BACKGROUND: Aneurysm clipping is routinely performed with high efficacy and low complication rates in specialized neurovascular centers. Postoperative aneurysm remnants bear the risk of growth/rupture. Study aim was to analyze remnants in postoperative angiography (pDSA) and follow-up (FU) and to evaluate whether …

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Guideline-Directed Medical Therapy for Heart Failure in Transthyretin Amyloid Cardiomyopathy

Stéphanie Kristina Schwarting, Thomas R.M. Bieber, Daniel R. Davies, Fabian aus dem Siepen et autres

Cardiac amyloidosis is an underdiagnosed cause of infiltrative cardiomyopathy, leading to heart failure across the spectrum of ejection fractions. Although there are approved disease-modulating therapies for the transthyretin subtype (transthyretin amyloid cardiomyopathy [ATTR-CM]), the role of heart failure medications remains uncertain and …

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Opportunistic osteoporosis screening in intraoperative CT can accurately identify patients with low volumetric bone mineral density and osteoporosis during spine surgery

Sebastian Rühling, Moritz Roman Hernández Petzsche, Maximilian T. Löffler, Nico Sollmann et autres

Abstract Purpose To evaluate the accuracy of opportunistic measurements of volumetric bone mineral density (vBMD) in intraoperative multi-detector CT (MDCT) scans, using preoperative MDCT as the reference. Methods This retrospective, single-center study included 105 patients (mean age: 73 ± 12.6 years, 53 …

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Microglia leave the brain parenchyma and migrate through the dura mater after craniotomy

Andrea Cattaneo, Alexandra Schwarz, Joshua James Shrouder, Gian Marco Calandra et autres

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Temporal Dynamics Of Ventricular Volume Alterations In A Murine Model Of Subarachnoid Hemorrhage

Biyan Nathanael Harapan, Dilara Ozsavas, Andrea Cattaneo, Julian Schwarting et autres

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Cervicothoracic volumetric bone mineral density assessed by opportunistic QCT may be a reliable marker for osteoporosis in adults

Constanze Ramschütz, Nico Sollmann, Malek El Husseini, Karina Kupfer et autres

This study aimed to validate the correlation between volumetric bone mineral density in the cervicothoracic and lumbar spine using measurements from opportunistic CT scans. The bone density assessment proved feasible, allowing us to propose optimal cut-off values for diagnosing osteoporosis and predicting …

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Cerebral blood flow from arterial spin labeling may serve as a marker for clinical outcome following large vessel occlusion and thrombectomy

Nico Sollmann, Gabriel Hoffmann, Johannes Buerkle, Claus Zimmer et autres

Motivation: Determination of a non-invasive imaging biomarker for outcome following ischemic stroke. Goal(s): To investigate whether cerebral blood flow from arterial spin labeling can be used as an imaging biomarker for assessment of clinical outcome following stroke with mechanical thrombectomy. Approach: Prospective …