Moritz Roman Hernández Petzsche

Perfusion Territory Shifts in Cerebrovascular Diseases Measured by Super‐Selective Arterial Spin Labeling

Gabriel Hoffmann, Miriam Reichert, Jens Göttler, Michael Helle et autres

BACKGROUND AND PURPOSE: Individualized diagnostic approaches are crucial in cerebrovascular diseases, such as internal carotid artery stenosis (ICAS). To evaluate individual collateral blood supply, vessel-selective imaging has gained high relevance. However, clinically established digital subtraction angiography (DSA) exposes patients to intervention risks …

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ISLES'24 - A Real-World Longitudinal Multimodal Stroke Dataset

Evamaria Olga Riedel, Ezequiel de la Rosa, The Anh Baran, Moritz Roman Hernández Petzsche et autres

This multi-center dataset consists of 149 acute ischemic stroke cases, representing the training set of the ISLES'24 challenge. All data are provided in NIfTI format (.nii.gz) and organized according to the BIDS standard. For each case, the following data are included: Admission …

DeepISLES: a clinically validated ischemic stroke segmentation model from the ISLES'22 challenge

Ezequiel de la Rosa, Mauricio Reyes, Sook‐Lei Liew, A. Hutton et autres

Diffusion-weighted MRI is critical for diagnosing and managing ischemic stroke, but variability in images and disease presentation limits the generalizability of AI algorithms. We present DeepISLES, a robust ensemble algorithm developed from top submissions to the 2022 Ischemic Stroke Lesion Segmentation challenge …

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Immunothrombolytic monocyte-neutrophil axes dominate the single-cell landscape of human thrombosis and correlate with thrombus resolution

Kami Pekayvaz, Badr Kilani, Markus Joppich, Luke Eivers et autres

phenotype. This immunothrombolytic axis results in thrombus resolution. Together, with this immune landscape of thrombosis, we provide a valuable resource and introduce the concept of "immunothrombolysis" with broad mechanistic and translational implications at the crossroad of inflammation and thrombosis.

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Opportunistic osteoporosis screening in intraoperative CT can accurately identify patients with low volumetric bone mineral density and osteoporosis during spine surgery

Sebastian Rühling, Moritz Roman Hernández Petzsche, Maximilian T. Löffler, Nico Sollmann et autres

Abstract Purpose To evaluate the accuracy of opportunistic measurements of volumetric bone mineral density (vBMD) in intraoperative multi-detector CT (MDCT) scans, using preoperative MDCT as the reference. Methods This retrospective, single-center study included 105 patients (mean age: 73 ± 12.6 years, 53 …

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Endovascular versus Best Medical Treatment for Acute Carotid Occlusion BelOw Circle of Willis (ACOBOW): The ACOBOW Study

Lukas Meyer, Gabriel Broocks, Maria Eleni Alexandrou, Álex Lüttich et autres

For patients with symptomatic acute occlusions of the internal carotid artery below the circle of Willis, endovascular and best medical treatment were both effective and safe therapeutic options.

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Cervicothoracic volumetric bone mineral density assessed by opportunistic QCT may be a reliable marker for osteoporosis in adults

Constanze Ramschütz, Nico Sollmann, Malek El Husseini, Karina Kupfer et autres

This study aimed to validate the correlation between volumetric bone mineral density in the cervicothoracic and lumbar spine using measurements from opportunistic CT scans. The bone density assessment proved feasible, allowing us to propose optimal cut-off values for diagnosing osteoporosis and predicting …

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Cerebral blood flow from arterial spin labeling may serve as a marker for clinical outcome following large vessel occlusion and thrombectomy

Nico Sollmann, Gabriel Hoffmann, Johannes Buerkle, Claus Zimmer et autres

Motivation: Determination of a non-invasive imaging biomarker for outcome following ischemic stroke. Goal(s): To investigate whether cerebral blood flow from arterial spin labeling can be used as an imaging biomarker for assessment of clinical outcome following stroke with mechanical thrombectomy. Approach: Prospective …

Functional Outcomes After Decompressive Surgery in Patients with Malignant Space-Occupying Cerebellar Infarction

Enayatullah Baki, Lea Baumgart, Victoria Kehl, F Hess et autres

Background and Purpose: Decompressive surgery is a potentially life-saving treatment in patients with malignant space-occupying cerebellar infarction. However, there is only limited literature on functional outcomes and complications after surgery. Our aim was to establish markers which predict poor outcome. Methods: We …

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Basilar Stenosis Reduces the Impact of Successful Recanalization on Outcome in Basilar Artery Occlusion

Moritz Roman Hernández Petzsche, Philip Hoelter, Sebastian Rühling, Julian Schwarting et autres

Background: Evidence from randomized controlled trials has shown a benefit for endovascular treatment in basilar artery occlusion. We aimed to show the effect of the recanalization result on outcome and determine the role of underlying basilar stenosis in a real-world setting. Methods: …

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Cerebral blood flow from arterial spin labeling as an imaging biomarker of outcome after endovascular therapy for ischemic stroke

Moritz Roman Hernández Petzsche, Johannes Bürkle, Gabriel Hoffmann, Claus Zimmer et autres

Arterial spin labeling (ASL) is a contrast agent-free magnetic resonance imaging (MRI) technique to measure cerebral blood flow (CBF). We sought to investigate effects of CBF within the infarct on outcome and risk of hemorrhagic transformation (HT). In 111 patients (median age: …

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Predictors of malignant swelling in space-occupying cerebellar infarction

Enayatullah Baki, Lea Baumgart, Victoria Kehl, F Hess et autres

Background Malignant swelling is a fatal complication that can occur abruptly in space-occupying cerebellar infarction. We aimed to establish markers that predict malignant swelling in cerebellar infarction. Methods We retrospectively analysed data of stroke patients who were treated in our hospital between …

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