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Elizabeth VanSickle, Sara M. Sarasua, Tracy Lowe, Farrell, Christopher, PhD et autres
The cover image is based on the article Genetic and Phenotypic Features of the Five Known Polyaminopathies: A Critical Narrative Review by Elizabeth A. VanSickle et al., https://doi.org/10.1002/ajmga.70029 . image
Cari Wells, Elizabeth VanSickle, André S. Bachmann, Julianne Michael et autres
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Elizabeth VanSickle, Sara M. Sarasua, Tracy Lowe, Christopher L. Farrell et autres
Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder–Robinson syndrome results from hemizygous loss‐of‐function variants in the spermine synthase ( SMS ) gene, resulting in decreased or …
Elizabeth VanSickle, Sara M. Sarasua, Tracy Brock Lowe, Christopher L. Farrell et autres
Polyaminopathies are a recently described family of rare genetic neurodevelopmental disorders. Polyaminopathies disrupt the biosynthesis of the primary polyamines: putrescine, spermidine, and spermine. Snyder-Robinson syndrome results from hemizygous loss-of-function variants in the spermine synthase (SMS) gene, resulting in decreased or complete loss …
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Sushrut Marathe, Rohit Joshi, Rongbing Yang, Gauri Shadambikar et autres
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Chad R. Schultz, Martin C. H. Gruhlke, Alan John Slusarenko, André S. Bachmann
Background/Aim: Allicin is a small-molecule natural product found in garlic (Allium sativum). We previously showed that allicin inhibits ornithine decarboxylase (ODC) in vitro and induces apoptotic cell death in pediatric neuroblastoma (NB) cancer cell cultures. However, its potency as an anticancer agent …
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Caleb P. Bupp, Elizabeth VanSickle, Julianne Michael, Chad R. Schultz et autres
Rare diseases impact approximately 1 in 10 people worldwide, and yet, less than 5% of all rare diseases currently have an approved treatment option available. This is due to many challenges unique to rare diseases, including small, diverse patient populations, the cost …
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Chad R. Schultz, Bilal Aleiwi, Xiaofeng Zhou, Kelly M. Suino-Powell et autres
High Resolution Image Download MS PowerPoint Slide We here describe the design, synthesis, and biological activity of novel ornithine decarboxylase (ODC) inhibitors that show significantly higher potency in vitro than α-difluoromethylornithine (DFMO), a U.S. Food and Drug Administration (FDA) approved drug. We …
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Elizabeth VanSickle, Chad R. Schultz, André S. Bachmann, Caleb P. Bupp
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Chad R. Schultz, Elizabeth VanSickle, Caleb P. Bupp, André S. Bachmann
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Matthew A. Swanson, Carlye Szarowicz, Schuyler Pike, Chad R. Schultz et autres
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Matthew A. Swanson, Carlye Szarowicz, Schuyler Pike, Chad R. Schultz et autres
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