Chase J. Taylor

Multiomic analysis identifies T cell subsets and mechanisms of epithelial interaction in idiopathic pulmonary fibrosis

Ana Pm Serezani, Julia M.R. Bazzano, Bruno D. Pascoalino, Ludmilla da Silva et autres

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by progressive scarring and respiratory failure. While T cells are elevated in IPF lungs, their contributions to fibrosis beyond inflammation remain poorly understood. Here, we performed multiplex imaging and single-cell RNA …

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T-cell Multiomic Analysis Identifies Subsets and Mechanisms of Interaction with Epithelial Cells in Idiopathic Pulmonary Fibrosis

Ana Serezani, Júlia Miranda Ribeiro Bazzano, Bruno D. Pascoalino, A. Dietrich et autres

Abstract Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by progressive scarring and respiratory failure, with a median survival of 3–5 years. While T-cell numbers are elevated in IPF lungs, their contributions to fibrosis beyond inflammation remain poorly understood. …

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Transcriptional and spatial profiling of T-Cell subsets in progressive pulmonary fibrosis 3627

Ana Pm Serezani, R.B. Bazzano, Bruno D. Pascoalino, Chase J. Taylor et autres

Abstract Description Idiopathic pulmonary fibrosis (IPF) is a severe condition that can lead to respiratory failure. T-cells are increased in IPF compared to non-diseased control lungs, but the contribution of T-cell subsets in pulmonary fibrosis (PF) remains unclear. We obtained lungs from …

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Spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis

Annika Vannan, Ruqian Lyu, Arianna L. Williams-Katek, Nicholas M. Negretti et autres

Large-scale changes in the structure and cellular makeup of the distal lung are a hallmark of pulmonary fibrosis (PF), but the spatial contexts that contribute to disease pathogenesis have remained uncertain. Using image-based spatial transcriptomics, we analyzed the gene expression of 1.6 …

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Pulmonary osteoclast-like cells in silica induced pulmonary fibrosis

Yoshihiro Hasegawa, Jennifer M. Franks, Yusuke Tanaka, Yasuaki Uehara et autres

The pathophysiology of silicosis is poorly understood, limiting development of therapies for those who have been exposed to the respirable particle. We explored mechanisms of silica-induced pulmonary fibrosis in human lung samples collected from patients with occupational exposure to silica and in …

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Sustained Activation of Yap/Taz After Injury Leads to Aberrant Alveolar Differentiation and Failure of Alveolar Repair

Jason J. Gokey, G.T. DiGiovanni, A. Scott McCall, Sergey Gutor et autres

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Author Correction: Cell-type-specific and disease-associated expression quantitative trait loci in the human lung

Heini M. Natri, Christina B. Azodi, Lance Peter, Chase J. Taylor et autres

In the version of the article initially published, in the legend to Fig. 6, the text now reading “Numbers of SNPs that were nominally significant ( P < 1 × 10 −6 ) in the IPF GWAS meta-analysis and also eQTL” originally …

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Cell-type-specific and disease-associated expression quantitative trait loci in the human lung

Heini M. Natri, Christina B. Azodi, Lance Peter, Chase J. Taylor et autres

Common genetic variants confer substantial risk for chronic lung diseases, including pulmonary fibrosis. Defining the genetic control of gene expression in a cell-type-specific and context-dependent manner is critical for understanding the mechanisms through which genetic variation influences complex traits and disease pathobiology. …

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Image-based spatial transcriptomics identifies molecular niche dysregulation associated with distal lung remodeling in pulmonary fibrosis

Annika Vannan, Ruqian Lyu, A. Williams, Nicholas M. Negretti et autres

The human lung is structurally complex, with a diversity of specialized epithelial, stromal and immune cells playing specific functional roles in anatomically distinct locations, and large-scale changes in the structure and cellular makeup of this distal lung is a hallmark of pulmonary …

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Epithelial Yap/Taz are required for functional alveolar regeneration following acute lung injury

G.T. DiGiovanni, Wei Han, Taylor P. Sherrill, Chase J. Taylor et autres

A hallmark of idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases is dysregulated repair of the alveolar epithelium. The Hippo pathway effector transcription factors YAP and TAZ are implicated as essential for type 1 and type 2 alveolar epithelial cell (AT1 …

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Epithelial Yap/Taz are required for functional alveolar regeneration following acute lung injury

G.T. DiGiovanni, Wei Han, Taylor P. Sherrill, Chase J. Taylor et autres

Abstract A hallmark of idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases is dysregulated repair of the alveolar epithelium. The Hippo pathway effector transcription factors YAP and TAZ have been implicated as essential for type 1 and type 2 alveolar epithelial …

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An integrated cell atlas of the lung in health and disease

Lisa Sikkema, Ciro Ramírez-Suástegui, Daniel Strobl, Tessa E. Gillett et autres

Abstract Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number of donors and disagree on cell type definitions. Integrating many single-cell datasets can address these limitations of individual studies and capture the variability present …

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