Chao Ma

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian et autres

Neuropathic pain results from aberrant sensory processing following nerve injury. Voltage-dependent anion channels (VDACs), a family of ATP gatekeepers in the outer mitochondrial membrane, are central to cellular metabolism and action potential generation, yet their roles in peripheral neuropathic pain remain poorly …

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Dorsal root ganglion macrophages mediate osteoarthritis pain via disruption of sensory neuron perineuronal nets

Fengrun Sun, Xiaofen Tian, Zhe Li, Ning Yu et autres

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Effects of Compaction Rotation Speed and Compaction Thickness in Roller-Compaction-Assisted Binder Jetting Additive Manufacturing

Wenchao Du, Mohammadamin Moghadasi, Xingjian Wei, Zhijian Pei et autres

Powder bed compaction can be used to control powder bed density in binder jetting additive manufacturing. Applying a forward-rotating roller to the powder bed is one of the methods for powder bed compaction. Both the compaction rotation speed and compaction thickness are …

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The Mechanism of Matrilin-2 Inhibiting the Progression of In-Stent Restenosis for Lower Extremity Arteriosclerosis Obliterans via TGF-β/Smad Signaling Pathway

Mintao Li, Chao Ma, Kangli Yin, Feng Lu et autres

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Global, regional, and national burden and trends of tension-type headache among adolescents and young adults (15–39 years) from 1990 to 2021: findings from the Global Burden of Disease study 2021

Chun-Lin Liu, Yingzhao Wang, Ming Liu, Chi Ma et autres

The prevalence of tension-type headache (TTH) is extremely high worldwide, but comprehensive global epidemiological studies targeting the specific age group of 15-39 years remain relatively limited. This study utilized data from the Global Burden of Disease 2021 (GBD 2021) study to analyze …

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Global, regional, and national trends and burden of hypertensive disorders in pregnancy among women of childbearing age from 1990 to 2021

Chao Ma, Liu Jin, Chongdong Liu

Background: Hypertensive disorders of pregnancy (HDP) are a significant cause of maternal and perinatal morbidity and mortality worldwide. This study aims to use the Global Burden of Disease 2021 database to analyze the prevalence trends and disease burden of HDP across the …

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PRMT3‐Mediated H4R3me2a Promotes Primary Age‐Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron

Haotian Liu, Xinnan Liu, Fengyuan Tian, Yashuang Chen et autres

Primary age-related tauopathy (PART) and Alzheimer's disease (AD) both exhibit 3R/4R hyperphosphorylated tau-positive neurofibrillary tangles (NFTs) within the hippocampal-entorhinal system. Notably, PART patients show a higher degree of tau hyperphosphorylation in the entorhinal cortex (EC) than AD, yet the molecular mechanisms driving …

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Whole genome sequencing informs SNP-based breeding strategies to safeguard genetic diversity in captive African lions

W Chen, Yujie Yang, Chao Ma, Lining Xia

Introduction: ) face severe population declines, making captive breeding programs essential for conservation. However, genetic data scarcity in such programs elevates inbreeding risks and threatens genetic diversity. Methods: Using next-generation sequencing (NGS), we analyzed genome-wide genetic markers from 10 captive African lions …

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Endosomal protein DENND10 promotes developmental competence of neurite extension

Aiqing Li, Jie Zhang, Chao Ma, Lijuan Qi et autres

A distinguishing feature of neurons is the presence of long neurites that enable far-reaching communication. Establishing this complex morphology requires precise regulation of intracellular transport and signaling. Our study identifies DENND10, an ancient endosomal protein, as a crucial factor in shaping neuron …

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Structural changes in cerebral microvasculature induced by ferroptosis contribute to blood–brain barrier disruption in Alzheimer's disease: an autopsy study

Yuan Cao, Meiying Huang, Chenhui Mao, Xue Wang et autres

INTRODUCTION: Cerebrovascular lesions are associated with cognitive impairment. However, the impact of AD neuropathological changes (ADNC) on cerebral microvasculature is not completely understood. METHODS: Twelve decedents with ADNC and 15 matched controls were selected from the Brain Bank. The changes in the …

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Prevalence of cerebral amyloid angiopathy and its correlation with Alzheimer's disease and cognition in an autopsy‐confirmed cohort from China

Xiang‐Sha Yin, Jianru Sun, Xue Wang, Wei Wu et autres

Abstract BACKGROUND We aimed to investigate the prevalence of cerebral amyloid angiopathy (CAA) and its correlations with Alzheimer's disease (AD) and cognitive impairment in an autopsy‐confirmed cohort donated to a human brain bank in Beijing, China. METHODS A total of 483 subjects …

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Global burden of polycystic ovary syndrome among women of childbearing age, 1990–2021: a systematic analysis using the global burden of disease study 2021

Yaping Meng, Ting Zhao, Rui Zhang, Xiaoyan Zhu et autres

Background The escalating global incidence of polycystic ovary syndrome (PCOS) necessitates a thorough examination of its epidemiological trends and sociodemographic correlations. Our study bridges this gap by analyzing the global impact of PCOS among women of childbearing age (WCBA) from 1990 to …

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