Kiran Chawla

Peer Review Report For: Development and evaluation of prevention bundle for neonatal healthcare-associated infections: an interventional study [version 2; peer review: 1 approved, 2 approved with reservations]

Usha Rani, Leslie E Lewis, Kiran Chawla, Anup Naha et autres

Background Neonatal healthcare-associated infection (HAI) globally is the leading preventable cause of neonatal mortality. Neonatal mortality in India is also very high. Considering that HAIs can be prevented globally, there are disparities in resources; the current study aimed at developing locally feasible …

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Genotypic distribution of hepatitis E virus among asymptomatic blood donors and its impact on transfusion safety

S Sangthang, N.P. Sudheesh, P. Pragathi, Kiran Chawla et autres

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Impact of repeat testing in tuberculosis patients with a trace call on Xpert MTB/RIF Ultra: a retrospective cohort study

Satya Narayan jha, Nitin Ranjan Gupta, Tirlangi Praveen Kumar, Kiran Chawla et autres

BACKGROUND: This study aimed to see if rifampicin susceptibility can be determined on repeat sampling in pulmonary tuberculosis with a trace call on the first GeneXpert Ultra report. METHODS: This retrospective cohort study included adults with a GeneXpert Ultra trace call in …

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Exploring the effects of probiotics on olanzapine-induced metabolic syndrome through the gut microbiota

Mushraf Syed, Kiran Chawla, Fayaz SM, Jesil Mathew Aranjani et autres

BACKGROUND: Maintaining gut microbial homeostasis is crucial for human health, as imbalances in the gut microbiota (GM) can lead to various diseases, including metabolic syndrome (MS), exacerbated by the use of antipsychotic medications such as olanzapine (OLZ). Understanding the role of the …

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The impact of anti-tuberculosis treatment on respiratory tract microbiome in pulmonary tuberculosis

Druti Hazra, Kiran Chawla, Fayaz SM, Vitali Sintchenko et autres

The growing evidence has underscored the significance of interactions between the host and microbiota in respiratory health, presenting a novel perspective on disease management. Yet, comprehension of the respiratory microbiome shifts before and after anti-tuberculosis treatment is limited. This study compares respiratory …

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Assessment of Hepatitis E virus transmission risks: a comprehensive review of cases among blood transfusion recipients and blood donors

Sangthang Singson, Shamee Shastry, N.P. Sudheesh, Kiran Chawla et autres

Background: Hepatitis E Virus is a major cause of acute and fulminant hepatitis, particularly in developing countries. While the virus is commonly spread through the fecal-oral route, numerous cases of transfusion transmitted Hepatitis E Virus (TT-HEV) have been reported, raising concerns about …

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Next generation sequencing to detect pathogens causing paediatric community-acquired pneumonia - A systematic review and meta-analysis

Kiran Chawla, Rosemary Shaji, Nayana Siddalingaiah, Sreenath Menon Pk et autres

BACKGROUND: Paediatric community-acquired pneumonia (CAP) is a major public health challenge in children, requiring accurate and timely diagnosis of causative pathogens for effective antibiotic treatment. We aimed to explore the utility of next-generation sequencing (NGS) in precise diagnosis of pediatric CAP and …

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Evaluating the economic viability of hepatitis E virus serological screening among blood donors: A prospective study from India for advancing blood safety

Sangthang Singson, Shamee Shastry, G Somu, Kiran Chawla

BACKGROUND: Hepatitis E virus (HEV) stands out as a significant transfusion-transmissible infection, yet it is not included in the screening protocols of many countries. The present study was conducted to assess the cost-benefit implications of incorporating HEV screening among blood donors which …

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Culture-Free Whole Genome Sequencing of Mycobacterium tuberculosis Using Ligand-Mediated Bead Enrichment Method

Shruthi Vasanthaiah, Renu Verma, Ajay Kumar, Aravind K. Bandari et autres

Abstract Background Direct whole genome sequencing (WGS) of Mycobacterium tuberculosis (Mtb) can be used as a tool to study drug resistance, mixed infections, and within-host diversity. However, WGS is challenging to obtain from clinical samples due to low number of bacilli against …

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Development and evaluation of prevention bundle for neonatal healthcare-associated infections: an interventional study

Usha Rani, Leslie Lewis, Kiran Chawla, Anup Naha et autres

Background: Neonatal healthcare-associated infection (HAI) globally is the leading preventable cause of neonatal mortality. Neonatal mortality in India is also very high. Considering that HAIs can be prevented globally, there are disparities in resources; the current study aimed at developing locally feasible …

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Identification of DprE1 inhibitors for tuberculosis through integrated in-silico approaches

Swagatika Dash, Ekta Rathi, Kiran Chawla, Suvarna G. Kini

Abstract Decaprenylphosphoryl-β-D-ribose-2′-epimerase (DprE1), a crucial enzyme in the process of arabinogalactan and lipoarabinomannan biosynthesis, has become the target of choice for anti-TB drug discovery in the recent past. The current study aims to find the potential DprE1 inhibitors through in-silico approaches. Here, …

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A ten-year experience of musculoskeletal tuberculosis at a tertiary care hospital in South India

Druti Hazra, Rosemary Shaji, Arushi Dhall, Arathi Prahallada Rao et autres

Background: The delayed identification and management of musculoskeletal tuberculosis (MSTB) poses substantial health challenges and leads to significant morbidity. This study aimed to collate ten years of hospital data and provide valuable insights into the clinical, diagnostics, and outcomes of the patients …

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