Margherita Ori

Impact of climate and urbanization on NTM infections: an Italian nationwide case-control study

Paola Faverio, Lorenzo Castello, Maura Spotti, Paola Rebora et autres

Nontuberculous mycobacteria (NTM) are opportunistic agents. Higher population densities and tropical/subtropical climates were associated with increased pulmonary NTM infection (pNTM). However, the impact of meteorological parameters and urbanization on NTM incidence in European countries is still unknown. Aim of this study was …

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How do climate conditions and urbanisation impact nontuberculous mycobacterial infections? An Italian nationwide case–control study

Paola Faverio, Lorenzo Castello, Maura Spotti, Paola Rebora et autres

Introduction Nontuberculous mycobacteria (NTM) are opportunistic pathogens primarily found in soil and water. Previous studies have linked higher population density and tropical/subtropical climates with increased NTM pulmonary disease (NTM-PD). However, the effects of meteorological parameters and population density on NTM incidence in …

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The impact of cardiovascular events in bronchiectasis: a systematic review and meta-analysis

Andrea Gramegna, Ivan Barone, Gianfranco Alicandro, Giovanni Sotgiu et autres

Background: Bronchiectasis is a chronic respiratory condition characterised by airway and systemic inflammation with prevalence increasing with age. Given the median age of the patients, it is common to observe the presence of comorbidities, particularly cardiovascular diseases, which have been linked to …

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Clinical characteristics and outcomes of vaccinated patients hospitalised with SARS-CoV-2 breakthrough infection: Multi-IPV, a multicentre study in Northern Italy

Andrea Lombardi, Simone Villa, Marta Colaneri, Giovanni Luca Scaglione et autres

BACKGROUND: Despite the well-known efficacy of anti-COVID-19 vaccines in preventing morbidity and mortality, several vaccinated individuals are diagnosed with SARS-CoV-2 breakthrough infection, which might require hospitalisation. This multicentre, observational, and retrospective study aimed to investigate the clinical characteristics and outcomes of vaccinated …

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Treatable traits and challenges in the clinical management of non-tuberculous mycobacteria lung disease in people with cystic fibrosis

Andrea Gramegna, Sofia Misuraca, Andrea Lombardi, Chiara Premuda et autres

INTRODUCTION: Over the last ten years an increasing prevalence and incidence of non-tuberculous mycobacteria (NTM) has been reported among patients with cystic fibrosis (CF) Viviani (J Cyst Fibros, 15(5):619-623, 2016). NTM pulmonary disease has been associated with negative clinical outcomes and often …

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Bronchiectasis associated to connective tissue diseases: a single-center experience

Anna Stainer, Andrea Gramegna, Edoardo Simonetta, Mattia Nigro et autres

The identification of connective tissue disease (CTD) in patients with bronchiectasis (BE) is crucial due to increased risk of mortality and hospitalization in CTD associated BE (CTD-BE), particularly in rheumatoid arthritis (RA). To explore prevalence and characteristics of CTD-BE, consecutive adults with …

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Non-tuberculous mycobacteria lung disease due to Mycobacterium chimaera in a 67-year-old man treated with immune checkpoint inhibitors for lung adenocarcinoma: infection due to dysregulated immunity?

Cecilia Azzarà, Andrea Lombardi, Andrea Gramegna, Margherita Ori et autres

Immune checkpoint inhibitors (ICIs) are drugs growingly employed in cancer immunotherapy which have significantly improved the prognosis of several tumours. ICIs act by restoring the "exhausted" immune system and increasing the number of T cells active against pathogens losing tolerogenic signalling, which …

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Non-tuberculous mycobacteria lung disease due to Mycobacterium chimaera in a 67-year- old man treated with immune checkpoint inhibitors for lung adenocarcinoma: infection due to dysregulated immunity?

Cecilia Azzarà, Andrea Lombardi, Andrea Gramegna, Margherita Ori et autres

Abstract Background: Immune checkpoint inhibitors (ICIs) are drugs growingly employed in cancer immunotherapy which have significantly improved the prognosis of several tumours. ICIs act by restoring the "exhausted" immune system against a specific pathogen and this have been linked to an increased …

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Nontuberculous mycobacterial infections during cancer therapy with immune checkpoint inhibitors: a systematic review

Andrea Lombardi, Andrea Gramegna, Margherita Ori, Cecilia Azzarà et autres

Immune checkpoint inhibitors (ICIs) are drugs growingly employed in the treatment of cancers, but there are still uncertainties about their possible role in the risk of developing nontuberculous mycobacteria (NTM) infections. To understand this, we performed a systematic review of the literature …

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Nontuberculous mycobacteria infection and pulmonary disease in bronchiectasis

Kseniia Suska, Francesco Amati, Giovanni Sotgiu, Andrea Gramegna et autres

Background Although interest in nontuberculous mycobacteria (NTM) infection has increased in the last decades, published data vary according to different geographical areas, diagnostic facilities and quality of study design. This study aims at assessing both prevalence and incidence of NTM infection and …

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Stenting versus balloon dilatation in patients with tracheal benign stenosis: The STROBE trial

Alessandro Marchioni, Dario Andrisani, Roberto Tonelli, Alessandro Andreani et autres

Abstract Background It is well known that benign tracheal stenosis represents an obstacle to open surgery, and that its treatment could be challenging. Two endoscopic techniques have so far been adopted to restore tracheal patency: balloon dilatation (BA) through laryngoscopy, and tracheal …

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Pulmonary nontuberculous mycobacterial infections and environmental factors: A review of the literature

Giulia Gardini, Margherita Ori, Luigi Ruffo Codecasa, Alberto Matteelli

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