Nontuberculous mycobacteria infection and pulmonary disease in bronchiectasis
Rattachement africain : ua, it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background Although interest in nontuberculous mycobacteria (NTM) infection has increased in the last decades, published data vary according to different geographical areas, diagnostic facilities and quality of study design. This study aims at assessing both prevalence and incidence of NTM infection and NTM pulmonary disease (NTM-PD) among adults with bronchiectasis, to describe patients’ characteristics, therapeutic options and clinical outcomes. Methods Bronchiectasis adults who had been tested for NTM were enrolled at the Bronchiectasis Program of the Policlinico Hospital in Milan, Italy, from 2016 to 2018. Results Among the 373 patients enrolled, 26.1% had at least one respiratory sample positive for NTM and 12.6% reached a diagnosis of NTM-PD. Incidence rates for NTM infection and NTM-PD were 13 (95% CI 10–16) and 4 (95% CI 2–6) per 100 person-years, respectively. The most prevalent NTM species causing NTM-PD wereM. intracellulare(38.3%),M. avium(34.0%),M. abscessus(8.5%) andM. kansasii(8.5%). Once treatment for NTM-PD was initiated, a favourable outcome was documented in 52.2% of the patients, while a negative outcome was recorded in 32.6%, including recurrence (17.4%), treatment failure (10.9%), re-infection (2.2%) and relapse (2.2%). Treatment halted was experienced in 11 (23.9%) patients. Conclusions NTM infection is frequent in bronchiectasis patients and the presence of NTM-PD is relevant. The low success rate of NTM-PD treatment in bronchiectasis patients requires a call to action to identify new treatment modalities and new drugs to improve patients’ outcomes.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Nontuberculous mycobacteria infection and pulmonary disease in bronchiectasis
- Date Crossref
- 01/10/2022
- Éditeur
- European Respiratory Society (ERS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Dnipro State Medical University Clinical Immunology and Clinical Pharmacology pays non établi dans la noticeÉtablissement de santé
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Humanitas University Dept of Biomedical Sciences pays non établi dans la noticeUniversité ou école supérieure
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IRCCS Humanitas Research Hospital Respiratory Unit pays non établi dans la noticeÉtablissement de santé
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University of Sassari Clinical Epidemiology and Medical Statistics Unit pays non établi dans la noticeUniversité ou école supérieure
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University of Milan Dept of Pathophysiology and Transplantation pays non établi dans la noticeUniversité ou école supérieure
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Respiratory Unit and Cystic Fibrosis Adult Center pays non établi dans la noticeÉtablissement de santé
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Villa Marelli Institute Regional TB Reference Centre pays non établi dans la noticeStructure de recherche
Clinical Immunology and Clinical Pharmacology — Dnipro State Medical University, Dept of Biomedical Sciences — Humanitas University et Respiratory Unit — IRCCS Humanitas Research Hospital, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.