The impact of cardiovascular events in bronchiectasis: a systematic review and meta-analysis
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Le résumé fourni par la source
Background: Bronchiectasis is a chronic respiratory condition characterised by airway and systemic inflammation with prevalence increasing with age. Given the median age of the patients, it is common to observe the presence of comorbidities, particularly cardiovascular diseases, which have been linked to adverse clinical outcomes. To investigate the pooled estimates of the association between bronchiectasis and coronary heart disease or stroke within this population, we conducted a systematic review and meta-analysis of the available scientific evidence. Methods: Three investigators independently performed the search on PubMed and other sources and included studies published up to October 2023 according to predefined criteria. Relative measures of association between bronchiectasis and cardiovascular events were pooled and meta-analysed using a fixed-effects model. Studies were evaluated using the Newcastle-Ottawa Scale for assessing the quality of non-randomised studies in meta-analyses. Results: A final pool of nine studies was included in the systematic review, with a total of 22 239 patients. Meta-analysis of three high-quality cohort studies showed a pooled hazard ratio of 1.42 (95% CI 1.30-1.57) for coronary heart disease and 1.71 (95% CI 1.55-1.89) for cerebrovascular stroke. Conclusions: The increased cardiovascular risk among people with bronchiectasis underscores the critical need to raise awareness of this association and to develop preventive strategies accordingly. Further translational studies are imperative to gain a deeper understanding of the complex interplay between inflammation, the immune system and endothelial dysfunction in this patient group.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The impact of cardiovascular events in bronchiectasis: a systematic review and meta-analysis
- Date Crossref
- 20/06/2024
- Éditeur
- European Respiratory Society (ERS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Milan Department of Pathophysiology and Transplantation pays non établi dans la noticeUniversité ou école supérieure
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Respiratory Unit and Cystic Fibrosis Adult Center pays non établi dans la noticeÉtablissement de santé
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University of Sassari Department of Medical pays non établi dans la noticeUniversité ou école supérieure
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Ospedale Maggiore Department of Cardio-Thoracic-Vascular Area pays non établi dans la noticeÉtablissement de santé
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University of Insubria Department of Medicine and Surgery pays non établi dans la noticeUniversité ou école supérieure
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Aziende Socio Sanitaria Territoriale Rhodense pays non établi dans la noticeOrganisme public
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IRCCS Humanitas Research Hospital Respiratory Unit pays non établi dans la noticeÉtablissement de santé
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Humanitas University Department of Biomedical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Department of Cardio-Thoracic-Vascular Area pays non établi dans la noticeInstitution
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Cardiology Division pays non établi dans la noticeInstitution
Department of Pathophysiology and Transplantation — University of Milan, Respiratory Unit and Cystic Fibrosis Adult Center — Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico et Department of Medical — University of Sassari, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.