Ruba Malkawi

Sustainable liquisolid compact system using fish viscera oil for enhanced dissolution and antioxidant activity of Baicalein

Ruba Malkawi

BACKGROUND: Baicalein (BA) is a flavonoid with significant pharmacological and antioxidant activities; however, its poor aqueous solubility and high crystallinity limit its dissolution and oral bioavailability. Liquisolid compact technology represents a promising approach for improving the dissolution behavior of poorly soluble drugs. …

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Design and Preparation of Solid Lipid Nanoparticles to Enhance Physicochemical Properties of Etoricoxib

Ahmed R. Gardouh, Ruba Malkawi, AHMED RAJA ALANEZI

Objective: Etoricoxib is a selective COX-2 inhibitor with poor aqueous solubility, which may limit its dissolution behavior and physicochemical performance. This study aimed to design, prepare, and optimize etoricoxib-loaded solid lipid nanoparticles (SLNs) to enhance the physicochemical properties and in vitro release …

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FORMULATION AND PHYSICOCHEMICAL CHARACTERIZATION OF PACLITAXEL-LOADED PLGA NANOPARTICLES WITH ENHANCED SOLUBILITY AND IN VITRO ANTICANCER ACTIVITY

Ruba Malkawi

Objective: Paclitaxel is a widely used chemotherapeutic agent with extremely poor aqueous solubility (~0.3 µg/ml), which significantly limits its bioavailability and therapeutic efficacy. The present study aimed to develop and characterize paclitaxel-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles to enhance solubility, dissolution behavior, and …

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Understanding the Role of Macrocycle Size and Amide Linkage in Teixobactin Analogues

Ruba Malkawi, James Weldon-Bee, Edwin Kiptoo, Sanjit Das et autres

Teixobactin is a promising antibiotic that targets cell wall biosynthesis in Gram-positive bacteria and displays a low propensity for resistance; however, its structural complexity presents challenges for analogue development and optimisation. In this study, we investigated the effects of macrocycle size and …

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β-Cyclodextrin–chitosan based carriers enhance the solubility and dissolution of baicalein through inclusion complex formation

Ruba Malkawi, Baraa Jarwan, Maram B. Alhawarri, Israa H. Isawi et autres

Baicalein (BA) is a poorly water-soluble flavonoid whose limited aqueous solubility restricts its oral bioavailability and pharmaceutical performance. This study aimed to enhance BA solubility and dissolution behavior through the development of binary (BA–β-cyclodextrin) and ternary (BA–β-cyclodextrin–chitosan) inclusion systems. Solid-state characterization was …

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Smart peptide-based drug delivery systems: Stimuli-responsive platforms for precision therapeutics

Ruba Malkawi

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Case Report: A Duodenal Polyp with Gastric Foveolar Metaplasia and Dysplasia

Khairat Battah, Arwa A. Battah, Ruba Malkawi, Mohammad Alkhreisat

Duodenal polyps are a common finding during endoscopic investigations, typically representing benign conditions such as regenerative or reactive changes and gastric heterotopia. Some regenerative changes can present as metaplasia, particularly of the gastric foveolar epithelial type. However, adenomatous changes associated with gastric …

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Discrepancies between pathologists and clinicians in interpretation of diagnostic uncertainty in surgical pathology reports

Khairat Battah, Arwa A. Battah, Iyad Farouji, Shifaa’ Al Qa'qa’ et autres

Pathologists frequently express diagnostic uncertainty in pathology reports, but such expressions may be interpreted differently by clinicians, potentially influencing patient management. This study evaluated how clinicians and pathologists interpret commonly used uncertain phrases in pathology reports and explored factors that influence the …

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Excipients in pharmaceuticals: mechanisms of hypersensitivity and the role of global pharmacovigilance

Ruba Malkawi, Lora Altahrawi

Excipients are important inactive components in drug formulations that ensure stability, bioavailability, and patient compliance. However, emerging evidence suggests that certain excipients, once considered inert, can cause hypersensitivity reactions in certain individuals. Such reactions include mild erythema due to systemic anaphylaxis and …

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Evaluating Artificial Intelligence Tools in the Pharmaceutical Industry: A Case Study on Paracetamol Dissolution and Calibration Curves

Ruba Malkawi

Purpose: This study evaluates the potential of artificial intelligence (AI), specifically ChatGPT, in assisting with the analysis of paracetamol dissolution tests and the construction of calibration curves. The primary research question investigates whether AI-generated data can approximate real laboratory results for pharmaceutical …

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Pharmaceutical Insights Into Ammi and Parsley: Evaluating Antioxidant Activity, Total Phenolic Content, and Kidney Stone Disintegration Properties

Ruba Malkawi, Mohammad Alkhreisat

(Parsley), specifically focusing on their antioxidant activity, total phenolic content, and efficacy in disintegrating calcium oxalate kidney stones. Ammi and Parsley extracts, known for their traditional medicinal uses, contain bioactive compounds with significant antioxidant properties that have attracted attention in pharmaceutical research. …

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UNLOCKING THE POTENTIAL: ENHANCING SOLUBILITY AND BIOAVAILABILITY OF ACYCLOVIR THROUGH SOLID DISPERSION FORMULATIONS

Ruba Malkawi, SULEIMAN AL-OLIMAT, JUMANA TAWALBEH

Objective: This study aimed to formulate and evaluate solid dispersions of acyclovir using Polyethylene Glycol (PEG) polymers (PEG 3350, PEG 4000, and PEG 6000) in varying ratios to improve their oral bioavailability. Methods: Solid dispersions of acyclovir with PEG 3350, PEG 4000, …

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