Maram B. Alhawarri

Synthesis, Characterization, and Biological Assessment of 2‐Methoxynicotinonitrile Derivatives

Eman M. Sulaiman, Eman Al‐Masri, Maram B. Alhawarri, Mohammad Ibrahim et autres

ABSTRACT This study presents the formation of 2‐methoxy‐3‐cyanopyridine derivatives 3(a–g) that occurred while attempting to synthesize furo[2,3‐ b ]pyridines. The structures of all newly synthesized compounds were confirmed by IR, 1 H NMR, 13 C NMR, 2D‐NMR, HRMS, and crystal x‐ray structure …

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Eco-Friendly Silver Nanoparticles Synthesized from an Alkaloid-Rich Extract of Androcymbium palaestinum: Optimization, Characterization, and Activity Against Antibiotic-Resistant Bacteria

Nusaiba K. Al‐Nemrawi, Tamam El‐Elimat, Alaa Alnaji, Majed Masadeh et autres

INTRODUCTION: Silver Nanoparticles (AgNPs) can be used as antimicrobial agents. Most chemical methods used to prepare AgNPs involve toxic and hazardous materials. Fortunately, "green nanotechnology" is considered safe, environmentally friendly, rapid, viable, scalable, and cost-effective. This method uses microorganisms or plant extracts …

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β-Cyclodextrin–chitosan based carriers enhance the solubility and dissolution of baicalein through inclusion complex formation

Ruba Malkawi, Baraa Jarwan, Maram B. Alhawarri, Israa H. Isawi et autres

Baicalein (BA) is a poorly water-soluble flavonoid whose limited aqueous solubility restricts its oral bioavailability and pharmaceutical performance. This study aimed to enhance BA solubility and dissolution behavior through the development of binary (BA–β-cyclodextrin) and ternary (BA–β-cyclodextrin–chitosan) inclusion systems. Solid-state characterization was …

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Synthesis, Characterization and Biological Evaluation of New Furo[2,3-b] pyridine Derivative: Molecular Docking, Antioxidant and Antimicrobial Activity Enhanced by Silver Nanoparticle Formulation

Menier Al‐Anazi, Mohammad Ibrahim, Abdullah Al-Fawwaz, Maram B. Alhawarri et autres

INTRODUCTION: Pyridine-based derivatives are well-known for their broad-spectrum therapeutic applications, particularly as antimicrobial and antioxidant agents. However, clinical utility is often hindered by poor aqueous solubility and limited bioavailability. This study aimed to synthesize and evaluate the biological activity, pharmacokinetic properties, and …

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Computational Insights Into New Portulaca oleracea Alkaloids as Potential SARS‐CoV‐2 PL pro Inhibitors

Mohammad Gasem Al-Thiabat, Maram B. Alhawarri

ABSTRACT The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) papain‐like protease (PL pro ) is a multifunctional enzyme essential for viral replication and immune evasion, representing a validated antiviral drug target. Natural alkaloids from Portulaca oleracea L. remain unexplored for their potential …

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In silico insights into (±)-zanthonitidumine B: anti-Inflammatory potency and enantiomeric selectivity through molecular docking, DFT, and MEP studies

Maram B. Alhawarri, Amit Dubey, Aisha Tufail, Mohammad Gasem Al-Thiabat

Inflammation becomes pathogenic when dysregulated, with interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) acting as central mediators. (±)-Zanthonitidumine B, a racemic benzophenanthridine alkaloid from Zanthoxylum nitidum , has been reported to suppress these cytokines. In this study, the enantiomers (+)-zanthonitidumine B and …

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Hypothesis-Driven Insights and Clinical Trial Updates in Alzheimer’s Disease Pathogenesis

Maram B. Alhawarri

INTRODUCTION: Alzheimer's disease (AD) is the primary cause of dementia and a significant threat to healthy aging. The prevalence of AD and other non-communicable diseases (NCDs) is significantly influenced by the progressive decline in physiological functions that is associated with aging. METHODS: …

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Schweinfurthiamide as a Promising Anticancer Agent: Molecular Docking, Dynamics, and ADMET Insights Targeting MTHFD2

Maram B. Alhawarri

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Synthesis, characterization, crystal structure, antioxidant and antimicrobial activity of 4-Aryl-2-cyanomethoxy-6-(2,5-dichlorothiophen-3-yl)nicotinonitrile derivatives

Eman M. Sulaiman, Mohammad Ibrahim, Mahmoud Al‐Refai, Maram B. Alhawarri et autres

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Theranostic Potential of Copper-64 ATSM Targeting MTHFD2: An In Silico Perspective on Hypoxia-Selective Imaging and Therapy

Abdulsalam Abuelsamen, Maram B. Alhawarri, Mohammad Gasem Al-Thiabat, Ghaseb Naser Makhadmeh et autres

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Targeting necroptosis in MCF-7 breast cancer cells: In Silico insights into 8,12-dimethoxysanguinarine from Eomecon Chionantha through molecular docking, dynamics, DFT, and MEP studies

Maram B. Alhawarri, Mohammad Gasem Al-Thiabat, Amit Dubey, Aisha Tufail et autres

Breast cancer remains a significant challenge in oncology, highlighting the need for alternative therapeutic strategies that target necroptosis to overcome resistance to conventional therapies. Recent investigations into natural compounds have identified 8,12-dimethoxysanguinarine (SG-A) from Eomecon chionantha as a potential necroptosis inducer. This …

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Potential MAO‐B Inhibitors from Cissampelos Capensis L.f.: ADMET, Molecular Docking, Dynamics, and DFT Insights

Mohammad Gasem Al-Thiabat, Mohit Agrawal, Kantrol Kumar Sahu, Maram B. Alhawarri et autres

This study explores the therapeutic potential of three proaporphine alkaloids-cissamaline, cissamanine, and cissamdine, which were recently isolated from Cissampelos capensis L.f., against Parkinson's disease (PD). Using computational techniques, we investigated their efficacy as inhibitors of a key protein in PD. ADMET analysis …

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