Shibojyoti Lahiri

Artery tertiary lymphoid organs encode a pathogenic high-affinity autoantibody−autoantigen pair in atherosclerosis

Chuankai Zhang, Xi Zhang, Yi Ran, Zhihua Wang et autres

Artery tertiary lymphoid organs (ATLOs) emerge in atherosclerosis, which is a chronic inflammatory artery disease with an autoimmune component. However, whether disease-relevant autoimmune B cells emerge in ATLOs remains unknown. In this study, we isolate germinal center (GC) B cells from ATLOs …

cn, de, sk, nl, it, gb, us (code pays fourni par la source)

Dysregulated sphingolipid metabolismdrives pancreatic carcinogenesis through plasma membrane Kras enrichment

Ahmed Alnatsha, Jianying Xu, Tahib Habshi, Qi Li et autres

Background As key constituents of cellular sphingolipid pools, sphingomyelin (SM) and ceramide (CER) are central to the regulation of cancer cell death and survival. The metabolic flux between these two lipids is a vital component of the cellular stress response, yet the …

pt, de, cn, at, in, fr (code pays fourni par la source)

Dbf4-dependent kinase finetunes Ino80 function at chromosome replication origins

Priyanka Bansal, Shibojyoti Lahiri, Chandni Natalia Kumar, Jessica Furtmeier et autres

The highly conserved Dbf4-Dependent Kinase (DDK) plays a pivotal role during S phase. It phosphorylates the replicative helicase (minichromosome maintenance, MCM complex), which leads to the initiation of replication. However, few other targets, besides the MCM complex, are known, leaving DDK an …

de, gb, es (code pays fourni par la source)

Fibre supplementation alters the gastrointestinal microbiome, the microbial metabolites and indicators of neurodegeneration in a mouse model of Alzheimer´s disease

Linda F. Böswald, Jasmin Wenderlein, Martin Bachmann, Annette Zeyner et autres

Alzheimer´s disease is a neurodegenerative disease with high global prevalence and no cure available. It is known that the microbiota-gut-brain-axis plays a role in the pathogenesis, but the pathways are not fully understood yet. To elucidate the role of dietary fibre supplementation …

de, at (code pays fourni par la source)

Self-Reactive B Cells in Artery Tertiary Lymphoid Organs Encode Pathogenic High Affinity Autoantibody in Atherosclerosis

Chuankai Zhang, Xi Zhang, Yong Ran, Zhihua Wang et autres

SUMMARY Artery tertiary lymphoid organs (ATLOs) emerge in atherosclerosis which is a chronic inflammatory artery disease with an autoimmune component. However, whether disease-relevant autoimmune B cells emerge in ATLOs and their impacts remains unknown. To map atherosclerosis-specific humoral autoimmunity and define its …

cn, de, sk, jp, nl, it, gb, us (code pays fourni par la source)

Dysregulated sphingolipid metabolism drives pancreatic carcinogenesis by interfering with Kras signalling

Ahmed Alnatsha, Ou Li, Klea Riçku, Jianying Xu et autres

de (code pays fourni par la source)

Enhanced In Situ Spatial Proteomics by Effective Combination of MALDI Imaging and LC-MS/MS

Archana Tomar, Shogo Sato, Raffaele Teperino, Axel Imhof et autres

Highly specialized cells are fundamental for the proper functioning of complex organs. Variations in cell-type-specific gene expression and protein composition have been linked to a variety of diseases. Investigation of the distinctive molecular makeup of these cells within tissues is therefore critical …

de, us (code pays fourni par la source)

Dbf4-Dependent Kinase Finetunes INO80 Function at Chromosome Replication Origins

Priyanka Bansal, Shibojyoti Lahiri, Chandni Natalia Kumar, Lorenzo Galanti et autres

Summary The highly conserved Dbf4-Dependent Kinase (DDK) plays a pivotal role in the nucleus during S phase, where it directly phosphorylates the replicative helicase, the minichromosome maintenance (MCM) complex. This leads to the initiation of chromosome replication. However, aside from the MCM …

de, gb, es (code pays fourni par la source)

Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ‐secretase activity

Gökhan Güner, Marlene Aßfalg, Kai Zhao, Tobias F. Dreyer et autres

Fn14 is a cell surface receptor with key functions in tissue homeostasis and injury but is also linked to chronic diseases. Despite its physiological and medical importance, the regulation of Fn14 signaling and turnover is only partly understood. Here, we demonstrate that …

de, us (code pays fourni par la source)

ImShot: An Open-Source Software for Probabilistic Identification of Proteins In Situ and Visualization of Proteomics Data

Wasim Aftab, Shibojyoti Lahiri, Axel Imhof

Imaging mass spectrometry (IMS) has developed into a powerful tool allowing label-free detection of numerous biomolecules in situ. In contrast to shotgun proteomics, proteins/peptides can be detected directly from biological tissues and correlated to its morphology leading to a gain of crucial …

de (code pays fourni par la source)

Exploring the Ion Channel TRPV2 and Testicular Macrophages in Mouse Testis

Katja Eubler, Pia Rantakari, Heidi Gerke, Carola Herrmann et autres

The cation channel TRPV2 is known to be expressed by murine macrophages and is crucially involved in their functionality. Macrophages are frequent cells of the mouse testis, an immune-privileged and steroid-producing organ. TRPV2 expression by testicular macrophages and possible changes associated with …

de, fi (code pays fourni par la source)

Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice

Elisa Murenu, Sarantos Kostidis, Shibojyoti Lahiri, Anna S. Geserich et autres

Photoreceptors are the light-sensing cells of the retina and the major cell type affected in most inherited retinal degenerations. Different metabolic pathways sustain their high energetic demand in physiological conditions, particularly aerobic glycolysis. The principal metabolome of the mature retina has been …

de, nl (code pays fourni par la source)