Rie Hosoi

Ethyl Pyruvate Promotes Wound Healing in Elastase-Induced Lung Injury in Mice as Assessed by Hyperpolarized 129Xe Magnetic Resonance Imaging

Atsuomi Kimura, Akihiro Shimokawa, Neil J. Stewart, Rie Hosoi et autres

Abstract Purpose Wound healing process in lung injury involves the activation of the mitogen-activated protein kinase (MAPK) pathway. In this study, we investigated the role of the MAPK pathway in wound healing in a murine model of emphysema using hyperpolarized 129 Xe …

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Factors In The Determination Of Coronary Flow Reserve In Patients With Type 2 Diabetes Mellitus

N. Tomizawa, Ozu H, Satoru Kamio, Rie Hosoi et autres

jp (code pays fourni par la source)

Ethyl Pyruvate Promotes Wound Healing in Elastase-Induced Lung Injury in Mice as Assessed by Hyperpolarized 129Xe Magnetic Resonance Imaging

Atsuomi Kimura, Akihiro Shimokawa, Neil J. Stewart, Rie Hosoi et autres

jp, gb (code pays fourni par la source)

Ex-vivo Imaging of Glial Energy Metabolism in the Neonatal Mouse Brain during Convulsive Seizures with Intranasal Radiotracer Administration

Rie Hosoi, Takahiro Hayakawa

Abstract Purpose In this study, we examined changes in glial energy metabolism in neonatal mouse brain images obtained under pathological conditions following intranasal administration of the radiotracer [2-14C]acetate. Procedures [2-14C]acetate was administered via the mouse nasal cavity, after which autoradiograms of the …

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Targeted Imaging of Lung Cancer with Hyperpolarized 129Xe MRI Using Surface-Modified Iron Oxide Nanoparticles as Molecular Contrast Agents

Atsuomi Kimura, Seiya Utsumi, Akihiro Shimokawa, Renya Nishimori et autres

Hyperpolarized 129Xe (HP 129Xe) MRI enables functional imaging of various lung diseases but has been scarcely applied to lung cancer imaging. The aim of this study is to investigate the feasibility of targeted imaging of lung cancer with HP 129Xe MRI using …

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Ex vivo imaging and analysis of ROS generation correlated with microglial activation in rat model with acute neuroinflammation induced by intrastriatal injection of LPS

Miho Shukuri, Miyu Uchino, Takafumi Sakamaki, Satoru Onoe et autres

Neuroinflammation and oxidative stress are hallmarks of neurodegenerative diseases. Microglia, the major important regulators of neuroinflammation, are activated in response to excessive generation of reactive oxygen species (ROS) from damaged cells and resulting in elevated and sustained damages. However, the relationship between …

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Evaluation of intracellular processes in quinolinic acid-induced brain damage by imaging reactive oxygen species generation and mitochondrial complex I activity

Rie Hosoi, Yuka Fujii, Hiroyuki Ohba, Miho Shukuri et autres

Abstract Purpose Our study aimed to elucidate the intracellular processes associated with quinolinic acid (QA)-induced brain injury by acquiring semiquantitative fluorescent images of reactive oxygen species (ROS) generation and positron emission tomography (PET) images of mitochondrial complex I (MC-I) activity. Methods Ex …

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Evaluation of Intracellular Processes in Quinolinic Acid-Induced Brain Damage by Imaging Reactive Oxygen Species Generation and Mitochondrial Complex I Activity

Rie Hosoi, Yuka Fujii, Hiroyuki Ohba, Miho Shukuri et autres

Abstract Purpose Our study aimed to elucidate the intracellular processes associated with quinolinic acid (QA)-induced brain injury by acquiring semiquantitative fluorescent images of reactive oxygen species (ROS) generation and positron emission tomography (PET) images of mitochondrial complex I (MC-I) activity.MethodsEx vivo fluorescent …

jp, gb (code pays fourni par la source)

Changes in 3 H-QNB binding to muscarinic acetylcholine receptors in the acquisition of epileptogenesis.

Rie Hosoi

Changes in benzodiazepine and muscarinic acetylcholine receptor binding in the acquisition of epileptogenesis.

Rie Hosoi

A Simple Ex Vivo Semiquantitative Fluorescent Imaging Utilizing Planar Laser Scanner: Detection of Reactive Oxygen Species Generation in Mouse Brain and Kidney

Rie Hosoi, Sota Sato, Miho Shukuri, Yuka Fujii et autres

OBJECTIVE: Oxidative stress plays an important role in the onset of many neuronal and peripheral disorders. We examined the feasibility of obtaining semiquantitative fluorescent images of reactive oxygen species (ROS) generation in mouse brain and kidney utilizing a planar laser scanner and …

jp (code pays fourni par la source)

Quantitative imaging of blood-brain barrier permeable or impermeable radio tracer in the brain after intranasal administration

Rie Hosoi