Miho Shukuri

Effect of Functional Groups Introduced into Radioiodinated Asymmetric Cyanine Dyes on Their In Vivo Behavior

Satoru Onoe, Shogo Kikuchi, Kaoru Yamamoto, Yuki Yanagawa et autres

After intravenous administration, some heptamethine cyanine dyes bind to serum albumin and accumulate in tumors via the enhanced permeability and retention effect. Additionally, asymmetric cyanine dyes have two indole moieties which allow conjugation of a low-molecular-weight anticancer agent to one of the …

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Preliminary In Vitro Biological Evaluation of a Strategy for Passive Intracellular Glutathione-Derived Glyoxalase I Inhibitor Delivery: A Novel Approach

Satoru Onoe, Tomohisa Suzuki, Ayami Hirano, Kano Takadou et autres

Derivatives of glutathione (γ-Glu-Cys-Gly) and glutathione-derived inhibitors of enzymes involved in glutathione-related metabolism can be used as therapeutic agents against various diseases. However, their intracellular delivery is difficult because of poor cell membrane permeability due to high hydrophilicity. Conventional design strategies to …

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Assessment of Radiolabelled Derivatives of R954 for Detection of Bradykinin B1 Receptor in Cancer Cells: Studies on Glioblastoma Xenografts in Mice

Miho Shukuri, Satoru Onoe, Risa Mokudai, Shin Murai et autres

Bradykinin B1 receptor (B1R) has garnered attention as a cancer therapeutic and diagnostic target. Several reports on radiolabelled derivatives of B1R antagonists have shown favourable properties as imaging agents in cells highly expressing hB1R following transfection. In the present study, we assessed …

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Synthesis and Preclinical Evaluation of 18F-Labeled Ketoprofen Methyl Esters for Cyclooxygenase-1 Imaging in Neuroinflammation.

Miho Shukuri, Aya Mawatari, Shuhei Takatani, Tsuyoshi Tahara et autres

F]FKTP-Me demonstrated suitable properties as a COX-1-specific probe in PET imaging of neuroinflammation.

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Development of 99mTc-labeled hexavalent c(RGDfK) peptide with optimized linker structure for in vivo imaging of integrin αvβ3

Yuki Mizuno, Kohta Kimura, Satoru Onoe, Miho Shukuri et autres

Ex vivo imaging and analysis of ROS generation correlated with microglial activation in rat model with acute neuroinflammation induced by intrastriatal injection of LPS

Miho Shukuri, Miyu Uchino, Takafumi Sakamaki, Satoru Onoe et autres

Neuroinflammation and oxidative stress are hallmarks of neurodegenerative diseases. Microglia, the major important regulators of neuroinflammation, are activated in response to excessive generation of reactive oxygen species (ROS) from damaged cells and resulting in elevated and sustained damages. However, the relationship between …

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Influence of Linker Molecules in Hexavalent RGD Peptides on Their Multivalent Interactions with Integrin αvβ3

Yuki Mizuno, Kohta Kimura, Satoru Onoe, Miho Shukuri et autres

Multivalent RGD peptides have been used as an excellent targeting vector to integrin α v β 3 -positive tumors. However, little attention has been paid to the influence of linker molecules in multivalent RGD peptides on their dissociation kinetics from tumor cells. …

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Evaluation of intracellular processes in quinolinic acid-induced brain damage by imaging reactive oxygen species generation and mitochondrial complex I activity

Rie Hosoi, Yuka Fujii, Hiroyuki Ohba, Miho Shukuri et autres

Abstract Purpose Our study aimed to elucidate the intracellular processes associated with quinolinic acid (QA)-induced brain injury by acquiring semiquantitative fluorescent images of reactive oxygen species (ROS) generation and positron emission tomography (PET) images of mitochondrial complex I (MC-I) activity. Methods Ex …

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Evaluation of Intracellular Processes in Quinolinic Acid-Induced Brain Damage by Imaging Reactive Oxygen Species Generation and Mitochondrial Complex I Activity

Rie Hosoi, Yuka Fujii, Hiroyuki Ohba, Miho Shukuri et autres

Abstract Purpose Our study aimed to elucidate the intracellular processes associated with quinolinic acid (QA)-induced brain injury by acquiring semiquantitative fluorescent images of reactive oxygen species (ROS) generation and positron emission tomography (PET) images of mitochondrial complex I (MC-I) activity.MethodsEx vivo fluorescent …

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A Simple Ex Vivo Semiquantitative Fluorescent Imaging Utilizing Planar Laser Scanner: Detection of Reactive Oxygen Species Generation in Mouse Brain and Kidney

Rie Hosoi, Sota Sato, Miho Shukuri, Yuka Fujii et autres

OBJECTIVE: Oxidative stress plays an important role in the onset of many neuronal and peripheral disorders. We examined the feasibility of obtaining semiquantitative fluorescent images of reactive oxygen species (ROS) generation in mouse brain and kidney utilizing a planar laser scanner and …

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平面レーザスキャナを用いた単純なex vivo半定量蛍光イメージング:マウス脳と腎臓における活性酸素種生成の検出【JST・京大機械翻訳】

Rie Hosoi, Sota Sato, Miho Shukuri, Fujii Yuka et autres

Unexpected decrease in in vivo binding of [3H]QNB in the mouse cerebral cortex in the developing brain - A comparison with [11C]NMPB

Osamu Inoue, Toshiyuki Sato, Kaoru Kobayashi, Antony D. Gee et autres

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