Daiki Tanno

Tirzepatide Attenuates Wire Injury-Induced Arterial Remodeling in Non-Diabetic and Diabetic Mice: Comparison with Semaglutide

Yusaku Mori, Naoya Osaka, Michishige Terasaki, Hironori Yashima et autres

Background: Glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP-1R) activation exert anti-diabetic and anti-obesity effects. Tirzepatide, a dual GIPR/GLP-1R agonist, has demonstrated cardiovascular benefits in clinical studies. However, the direct vascular actions of tirzepatide and their potential advantages over selective …

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Casein- and Soy-Based High-Protein Diets Differentially Affect Insulin Resistance and Adipose Tissue Advanced Glycation End Product Accumulation in Obese Diabetic Mice

Yoshie Shiraga, Yusaku Mori, Naoya Osaka, Michishige Terasaki et autres

Background: Replacing dietary carbohydrates with protein has been proposed as a nutritional strategy to improve glycemic control and reduce obesity in individuals with type 2 diabetes. However, high-protein diets (HPDs) may also facilitate the formation of advanced glycation end products (AGEs), pathogenic …

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Effect of recent SARS-CoV-2 infection on anti-spike protein immunoglobulin G II response after BNT162b2 vaccination

Daiki Tanno, Yasuka Hara, Y. Sugaya, Koji Okuaki et autres

Objectives Our hospital experienced a SARS-CoV-2 outbreak 3 months before staff vaccination was initiated. This study compared antibody responses to the first and second doses of BNT162b2 mRNA vaccine among staff with and without prior infection. Methods Serum anti-spike (S) protein immunoglobulin …

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Evaluation of a nucleic acid amplification system, GENECUBE, for rapid detection of staphylococcal nuc and mecA in blood culture samples

Yasuka Hara, Daiki Tanno, Masahiro Toyokawa, Yukiko Takano et autres

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Antiviral Effects of Ozonated Water for Handwashing Against SARS-CoV-2 Omicron Variant Using the E1052-20 Test Method of the American Society of Testing Materials International

Kiwamu Nakamura, Daiki Tanno, Kazuhiro Kitakawa, S. Fujita et autres

Alcohol-based hand rubs are generally recommended for infection control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hand hygiene agents, including ozonated water (OW), have been used as an alternative because alcohol-based products may cause skin damage. A few reports are available …

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Validation of a modified enrichment broth for efficient screening of group B Streptococcus in pregnant women

Daiki Tanno, Kyoichi Saito, Yasuaki Tomii, Yukari Nakatsuka et autres

We validated a modified enrichment broth that changes its color when group B Streptococcus (GBS) grows. No GBS was detected in any of the non-yellow samples. Thus, the non-yellow samples were considered GBS-negative without conducting further examinations, potentially reducing medical costs and …

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Innate phase production of IFN-γ by memory and effector T cells expressing early activation marker CD69 during infection with Cryptococcus deneoformans in the lungs

Anna Miyahara, Aya Umeki, Ko Sato, Toshiki Nomura et autres

ABSTRACT Cryptococcus deneoformans is a yeast-type fungus that causes fatal meningoencephalitis in immunocompromised patients and evades phagocytic cell elimination through an escape mechanism. Memory T (Tm) cells play a central role in preventing the reactivation of this fungal pathogen. Among these cells, …

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In vitro activity of tedizolid against 43 species of Nocardia species

Masahiro Toyokawa, Noboru Ohana, Daiki Tanno, Minako Imai et autres

Abstract The purpose of the present study was to evaluate the in vitro activity of tedizolid against several clinically significant species of Nocardia by comparing with that of linezolid. A total of 286 isolates of Nocardia species, including 236 clinical isolates recovered …

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A Multicenter Study on the Utility of Selective Enrichment Broth for Detection of Group B Streptococcus in Pregnant Women in Japan

Daiki Tanno, Kyoichi Saito, Yasuaki Tomii, Yukari Nakatsuka et autres

Universal screening for Streptococcus agalactiae, Group B Streptococcus (GBS), in pregnant women is important for the prevention of severe infectious diseases in neonates. The subculture method using selective enrichment broth significantly improves GBS detection rates in the United States; however, this method …

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Nocardia sputorum sp. nov., an actinobacterium isolated from clinical specimens in Japan

Moriyuki Hamada, Narumi Enomoto, Tomonari Yamashita, Masahiro Shimojima et autres

Two novel actinobacteria, designated IFM 12276T and IFM 12275, were isolated from clinical specimens in Japan, and their taxonomic positions were investigated using a polyphasic approach. Phylogenetic analysis based on 16S rRNA gene sequence comparisons revealed that strains IFM 12276 T and …

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Detection of Clostridioides difficile toxin B gene in clinical stool specimens using rapid diagnostic quenching probe-polymerase chain reaction assay

Yasuka Hara, Kiwamu Nakamura, Daiki Tanno, Masahiro Toyokawa et autres

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Matrix-Assisted Laser Desorption Ionization–Time-of-Flight Mass Spectrometry with Time-of-Flight Peak Analysis for Rapid and Accurate Detection of Group B Streptococcus in Pregnant Women

Daiki Tanno, Kyoichi Saito, Kazutaka Ohashi, Masahiro Toyokawa et autres

As previously reported, 10%-30% of pregnant women carry Streptococcus agalactiae, Group B Streptococcus (GBS), in their vagina or rectum, and approximately 50% of them vertically transmit GBS to their neonates during labor or birth. Moreover, 1%-2% of the GBS-transmitted neonates develop severe …

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