Antonina Torre

The Antimicrobial, Antibiofilm and Anti-Inflammatory Activities of P13#1, a Cathelicidin-like Achiral Peptoid

Valeria Cafaro, Andrea Bosso, Ilaria Di Nardo, Assunta D’Amato et autres

Cationic antimicrobial peptides (CAMPs) are powerful molecules with antimicrobial, antibiofilm and endotoxin-scavenging activities. These properties make CAMPs very attractive drugs in the face of the rapid increase in multidrug-resistant (MDR) pathogens, but they are limited by their susceptibility to proteolytic degradation. An …

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Auto-Assembling Detoxified Staphylococcus aureus Alpha-Hemolysin Mimicking the Wild-Type Cytolytic Toxin

Luigi Fiaschi, Benedetta Di Palo, Maria Scarselli, Clarissa Pozzi et autres

Staphylococcus aureus alpha-hemolysin (Hla) assembles into heptameric pores on the host cell membrane, causing lysis, apoptosis, and junction disruption. Herein, we present the design of a newly engineered S. aureus alpha-toxin, HlaPSGS, which lacks the predicted membrane-spanning stem domain. This protein is …

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One Dose of Staphylococcus aureus 4C-Staph Vaccine Formulated with a Novel TLR7-Dependent Adjuvant Rapidly Protects Mice through Antibodies, Effector CD4+ T Cells, and IL-17A

Francesca Mancini, Elisabetta Monaci, Giuseppe Lofano, Antonina Torre et autres

A rapidly acting, single dose vaccine against Staphylococcus aureus would be highly beneficial for patients scheduled for major surgeries or in intensive care units. Here we show that one immunization with a multicomponent S. aureus candidate vaccine, 4C-Staph, formulated with a novel …

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A stable luciferase reporter plasmid for in vivo imaging in murine models of Staphylococcus aureus infections

Marta Bacconi, Andreas F. Haag, Antonina Torre, Andrea Castagnetti et autres

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MF59- and Al(OH)3-Adjuvanted Staphylococcus aureus (4C-Staph) Vaccines Induce Sustained Protective Humoral and Cellular Immune Responses, with a Critical Role for Effector CD4 T Cells at Low Antibody Titers

Elisabetta Monaci, Francesca Mancini, Giuseppe Lofano, Marta Bacconi et autres

Staphylococcus aureus (S. aureus) is an important opportunistic pathogen that may cause invasive life-threatening infections, like sepsis and pneumonia. Due to the increasing antibiotic resistance, the development of an effective vaccine against S. aureus is needed. Although a correlate of protection against …

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Four-Component Staphylococcus aureus Vaccine 4C-Staph Enhances Fcγ Receptor Expression in Neutrophils and Monocytes and Mitigates S. aureus Infection in Neutropenic Mice

Antonina Torre, Marta Bacconi, Chiara Sammicheli, Bruno Galletti et autres

Staphylococcus aureus is a human bacterial pathogen causing a variety of diseases. The occurrence of multidrug-resistant strains of Staphylococcus aureus underlines the need for a vaccine. Defining immune correlates of protection may support the design of an effective vaccine. We used a …

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Vaccine composition formulated with a novel TLR7-dependent adjuvant induces high and broad protection against Staphylococcus aureus

Fábio Bagnoli, Maria Rita Fontana, Elisabetta Soldaini, Ravi P.N. Mishra et autres

Both active and passive immunization strategies against Staphylococcus aureus have thus far failed to show efficacy in humans. With the attempt to develop an effective S. aureus vaccine, we selected five conserved antigens known to have different roles in S. aureus pathogenesis. …

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107 CIGB-247: Anti-VEGF therapeutic vaccine in patients with advanced solid tumors

Francisco Hernández‐Bernal, Jorge Gavilondo, Maira A. Castaneda Avila, Antonina Torre et autres

Specific active immunotherapy with a VEGF vaccine in patients with advanced solid tumors. Results of the CENTAURO antigen dose escalation phase I clinical trial

Jorge Gavilondo, Francisco Hernández‐Bernal, Marta Ayala‐Ávila, Antonina Torre et autres

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