Accès ouvert
2026
article
OpenAlex
Jonah Clegg, Giovanni Cova, Alberto Carignano, Megan Smith et autres
ABSTRACT Staphylococcus aureus is a leading cause of skin and soft tissue infections (SSTIs), yet the cellular mediators of protective memory remain incompletely defined. Using a self‐resolving murine SSTI model, we combined longitudinal single‐cell RNA sequencing with flow cytometry to characterize immune …
ie, it, us
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Accès ouvert
2025
article
OpenAlex
Sonia Budroni, Elisa Faenzi, Simona Tavarini, Chiara Sammicheli et autres
Background Protein-polysaccharide conjugate vaccines rely on the induction of T-cell-dependent responses that support germinal center (GC) reactions to potentiate the expansion of antigen-specific memory B-cell (MBC) populations and high-avidity antibody responses. The effects of adjuvants on B-cell and antibody responses are well …
it
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Accès ouvert
2025
article
OpenAlex
Matteo Ridelfi, Giacomo Vezzani, Emanuele Roscioli, Giampiero Batani et autres
Shigellosis is a global public health challenge that mostly affects low- and middle-income countries and causes considerable morbidity and mortality among children under 5 y of age. Multi- and extensively drug-resistant Shigella sonnei strains associated with recent outbreaks in high-income countries exacerbate …
it, us, in, nl, fr
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Accès ouvert
2025
article
OpenAlex
Marco Spinsanti, Elisabetta Monaci, Giacomo Romagnoli, Giada Buffi et autres
Gonorrhea, caused by Neisseria gonorrhoeae (GC) represents a significant public health threat that may be mitigated by an effective vaccine. Vaccines containing N. meningitidis outer membrane vesicles (OMVs), such as 4CMenB, demonstrated moderate effectiveness in preventing GC infections. Here, we developed NgG, …
in
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2025
article
OpenAlex
Marco Troisi, Monica Fabbrini, Samuele Stazzoni, Viola Viviani et autres
Gonococcus, a bacterium resistant to most antibiotics, causes more than 80 million cases of gonorrhea annually and is considered a high-priority pathogen by the World Health Organization. Recently, vaccine development prospects were boosted by reports that licensed meningococcus serogroup B (MenB) vaccines …
it, ar, gb
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Accès ouvert
2025
article
OpenAlex
Giacomo Vezzani, Viola Viviani, Martina Audagnotto, Alessandro Rossi et autres
Introduction: The 4CMenB vaccine licensed against serogroup B Neisseria meningitidis (MenB) contains three recombinant proteins and Outer Membrane Vesicles (OMV) from a New Zealand epidemic strain. The protective response mediated on differentmeningococcal strains has been historically ascribed to one of the four …
it, ar
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Accès ouvert
2025
article
OpenAlex
Jonah Clegg, Malgorzata Ewa Mnich, Alberto Carignano, Giovanni Cova et autres
Staphylococcus aureus poses an enormous burden of morbidity and mortality worldwide. Making an efficacious vaccine has however proven extremely challenging. Due to colonizing interactions, pre-existing S. aureus -specific CD4 + T cells are often found in the human population and yet a …
ie, nl
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Accès ouvert
2024
article
OpenAlex
Serena Tondi, Emilio Siena, Ahmed Essaghir, Benoît Bozzetti et autres
Shigellosis, an acute gastroenteritis infection caused by Shigella species, remains a public health burden in developing countries. Recently, many outbreaks due to Shigella sonnei multidrug-resistant strains have been reported in high-income countries, and the lack of an effective vaccine represents a major …
it
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Accès ouvert
2023
preprint
OpenAlex
Marco Troisi, Monica Fabbrini, Samuele Stazzoni, Viola Viviani et autres
ABSTRACT Gonococcus (Gc), a bacterium resistant to most antibiotics causing more than 80 million cases of gonorrhea annually, is a WHO high priority pathogen. Recently, vaccine development prospects were boosted by reports that licensed meningococcus serogroup B (MenB) vaccines provided partial protection …
it, gb
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Accès ouvert
2022
article
OpenAlex
Emilio Siena, Francesca Schiavetti, Erica Borgogni, Marianna Taccone et autres
The candidate Adjuvant System AS37 contains a synthetic toll-like receptor agonist (TLR7a) adsorbed to alum. In a phase I study (NCT02639351), healthy adults were randomised to receive one dose of licensed alum-adjuvanted meningococcal serogroup C (MenC-CRM197) conjugate vaccine (control) or MenC-CRM197 conjugate …
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Accès ouvert
2022
article
OpenAlex
Serena Tondi, Bruna Clemente, Carmen Esposito, Chiara Sammicheli et autres
Generalized Modules for Membrane Antigens (GMMA) are outer membrane exosomes purified from Gram-negative bacteria genetically mutated to increase blebbing and reduce risk of reactogenicity. This is commonly achieved through modification of the lipid A portion of lipopolysaccharide. GMMA faithfully resemble the bacterial …
it, gb
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Accès ouvert
2021
article
OpenAlex
Trine Sundebo Meldgaard, Fabiola Blengio, Denise Maffione, Chiara Sammicheli et autres
CD8+ T cells play a key role in mediating protective immunity after immune challenges such as infection or vaccination. Several subsets of differentiated CD8+ T cells have been identified, however, a deeper understanding of the molecular mechanism that underlies T-cell differentiation is …
it
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