Elisabetta Soldaini

Single‐Cell Profiling Identifies Skin‐Resident Memory CD4 + T Cells as a Potential Correlate of Immunity During Staphylococcus aureus Skin Infection

Jonah Clegg, Giovanni Cova, Alberto Carignano, Megan Smith et autres

ABSTRACT Staphylococcus aureus is a leading cause of skin and soft tissue infections (SSTIs), yet the cellular mediators of protective memory remain incompletely defined. Using a self‐resolving murine SSTI model, we combined longitudinal single‐cell RNA sequencing with flow cytometry to characterize immune …

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Pathobiont immune tuning: the untold consequences of Staphylococcus aureus exposure on host immunity

Seán Cahill, Elisabetta Soldaini, Rachel M. McLoughlin

Staphylococcus aureus is a formidable pathogen and major challenge to human health. However, the bacterium is dichotomous and also acts as an asymptomatic coloniser. Given its ubiquity, every individual has been exposed to the bacterium, which may 'tune' the host immune system. …

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Staphylococcus aureus-specific TIGIT+ Treg are present in the blood of healthy subjects – a hurdle for vaccination?

Jonah Clegg, Malgorzata Ewa Mnich, Alberto Carignano, Giovanni Cova et autres

Staphylococcus aureus poses an enormous burden of morbidity and mortality worldwide. Making an efficacious vaccine has however proven extremely challenging. Due to colonizing interactions, pre-existing S. aureus -specific CD4 + T cells are often found in the human population and yet a …

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Dissecting the Human Response to Staphylococcus aureus Systemic Infections

Rosanna Leuzzi, Margherita Bodini, Isaac P. Thomsen, Elisabetta Soldaini et autres

Staphylococcus aureus is a common human commensal and the leading cause of diverse infections. To identify distinctive parameters associated with infection and colonization, we compared the immune and inflammatory responses of patients with a diagnosis of invasive S. aureus disease to healthy …

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Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies

Jonah Clegg, Elisabetta Soldaini, Rachel M. McLoughlin, Stephen F. Rittenhouse et autres

Staphylococcus aureus is one of the most important human pathogens worldwide. Its high antibiotic resistance profile reinforces the need for new interventions like vaccines in addition to new antibiotics. Vaccine development efforts against S. aureus have failed so far however, the findings …

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Staphylococcus aureus-Specific Tissue-Resident Memory CD4+ T Cells Are Abundant in Healthy Human Skin

Astrid Hendriks, Malgorzata Ewa Mnich, Bruna Clemente, Ana Rita Cruz et autres

The skin is an immunocompetent tissue that harbors several kinds of immune cells and a plethora of commensal microbes constituting the skin microbiome. Staphylococcus aureus is a prominent skin pathogen that colonizes a large proportion of the human population. We currently have …

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Targeting Skin-Resident Memory T Cells via Vaccination to Combat Staphylococcus aureus Infections

Jonah Clegg, Elisabetta Soldaini, Fábio Bagnoli, Rachel M. McLoughlin

Tissue-resident memory T cells are important in adaptive immunity against many infections, rendering these cells attractive potential targets in vaccine development. Genetic and experimental evidence highlights the importance of cellular immunity in protection from Staphylococcus aureus skin infections, yet skin-resident memory T …

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Human Three-Dimensional Models for Studying Skin Pathogens

Elena Boero, Malgorzata Ewa Mnich, Andrea Guido Oreste Manetti, Elisabetta Soldaini et autres

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Correction to: Human Organotypic Models for Anti-infective Research

Astrid Hendriks, Ana Rita Cruz, Elisabetta Soldaini, Andrea Guido Oreste Manetti et autres

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Human Organotypic Models for Anti-infective Research

Astrid Hendriks, Ana Rita Cruz, Elisabetta Soldaini, Andrea Guido Oreste Manetti et autres

The use of human organotypic models for biomedical research is experiencing a significant increase due to their biological relevance, the possibility to perform high-throughput analyses, and their cost efficiency. In the field of anti-infective research, comprising the search for novel antipathogenic treatments …

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One Dose of Staphylococcus aureus 4C-Staph Vaccine Formulated with a Novel TLR7-Dependent Adjuvant Rapidly Protects Mice through Antibodies, Effector CD4+ T Cells, and IL-17A

Francesca Mancini, Elisabetta Monaci, Giuseppe Lofano, Antonina Torre et autres

A rapidly acting, single dose vaccine against Staphylococcus aureus would be highly beneficial for patients scheduled for major surgeries or in intensive care units. Here we show that one immunization with a multicomponent S. aureus candidate vaccine, 4C-Staph, formulated with a novel …

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MF59- and Al(OH)3-Adjuvanted Staphylococcus aureus (4C-Staph) Vaccines Induce Sustained Protective Humoral and Cellular Immune Responses, with a Critical Role for Effector CD4 T Cells at Low Antibody Titers

Elisabetta Monaci, Francesca Mancini, Giuseppe Lofano, Marta Bacconi et autres

Staphylococcus aureus (S. aureus) is an important opportunistic pathogen that may cause invasive life-threatening infections, like sepsis and pneumonia. Due to the increasing antibiotic resistance, the development of an effective vaccine against S. aureus is needed. Although a correlate of protection against …

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