Olayemi Olufikayo Adeoye

Methodological rigor and reporting quality of clinical practice guidelines for adults hospitalized with bacterial pneumonia: a scoping review

Amy Hagedorn Wonder, Jan Marie Nick, Olayemi Olufikayo Adeoye, Gurmeet Sehgal

OBJECTIVE: This scoping review describes the methodological rigor and reporting quality of clinical practice guidelines for adults hospitalized with bacterial pneumonia. INTRODUCTION: Health care professionals rely on clinical practice guidelines as authoritative sources for evidence-based treatment recommendations. To increase awareness of the …

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Perinatal glucocorticoid sensitivity in the preterm newborn: molecular mechanisms, endogenous determinants, and clinical implications

Nana A. O. Anti, Ciprian P. Gheorghe, Douglas D. Deming, Olayemi Olufikayo Adeoye et autres

Glucocorticoids are steroid hormones that regulate multiple physiological processes throughout the lifespan and play a central role in the adaptive stress response. Their biological effects are mediated by the glucocorticoid receptor, which acts through both genomic and nongenomic mechanisms to regulate transcriptional …

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Enhancing Educational Outcomes for Hispanic/LatinX Scholars in Pharmacy Education

Willie Davis, Lynn D. Lopez, Jody M. Gonzalez, Olayemi Olufikayo Adeoye et autres

Objective: This study evaluates the impact of the HRSA-funded Hispanic Center of Excellence in Pharmacy (HCEP) at Loma Linda University School of Pharmacy, initiated in 2022, on improving educational outcomes for Hispanic/LatinX PharmD and Pharm Tech scholars.

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Dysregulation of Glucocorticoid Receptor Homeostasis and Glucocorticoid-Associated Genes in Umbilical Cord Endothelial Cells of Diet-Induced Obese Pregnant Sheep

Eugenia Mata‐Greenwood, Wendy L. Chow, Nana A. O. Anti, LeeAnna D. Sands et autres

Maternal obesity (MO) is associated with offspring cardiometabolic diseases that are hypothesized to be partly mediated by glucocorticoids. Therefore, we aimed to study fetal endothelial glucocorticoid sensitivity in an ovine model of MO. Rambouillet/Columbia ewes were fed either 100% (control) or 150% …

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Methodological rigor and reporting quality of clinical practice guidelines for adults hospitalized with bacterial pneumonia: a scoping review protocol

Amy Hagedorn Wonder, Jan Marie Nick, Olayemi Olufikayo Adeoye, Gurmeet Sehgal

OBJECTIVE: This scoping review will present a profile of methodological rigor and reporting quality of clinical practice guidelines for adults hospitalized with bacterial pneumonia. INTRODUCTION: An ideal clinical practice guideline is evidence-based and the product of a rigorous and robust literature-vetted process, …

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AhR ligand aminoflavone suppresses α6‐integrin–Src–Akt signaling to attenuate tamoxifen resistance in breast cancer cells

Petreena S. Campbell, Nicole Mavingire, Salma Khan, Leah K. Rowland et autres

More than 40% of patients with luminal breast cancer treated with endocrine therapy agent tamoxifen demonstrate resistance. Emerging evidence suggests tumor initiating cells (TICs) and aberrant activation of Src and Akt signaling drive tamoxifen resistance and relapse. We previously demonstrated that aryl …

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Long‐term Hypoxia Alters Cytochrome P450 Activity During Pregnancy in Ovine Species

Hillary Truong, Tran Chau Lam, Sara Solak, Olayemi Olufikayo Adeoye

The absolute avoidance of medication during pregnancy, though desired, might not be practical because of preexisting co‐morbidities, pregnancy induced disorders (e.g. gestational diabetes), preeclampsia, or even fetal disorders. When indicated, the use of medication could be a major source of stress and …

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Chronic hypoxia alters fetal cerebrovascular responses to endothelin-1

Jinjutha Silpanisong, Dahlim Kim, James Michael Williams, Olayemi Olufikayo Adeoye et autres

In utero hypoxia influences the structure and function of most fetal arteries, including those of the developing cerebral circulation. Whereas the signals that initiate this hypoxic remodeling remain uncertain, these appear to be distinct from the mechanisms that maintain the remodeled vascular …

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Hypoxic Regulation of Vascular Proteasomal Degradation of MLCK

Olayemi Olufikayo Adeoye, Dane W. Sorensen, James Michael Williams, William J. Pearce

Chronic exposure of in‐utero fetuses to severe hypoxia induces maladaptive changes in vascular structure and function, and elevates postnatal susceptibility to metabolic, endocrine, cardiovascular diseases. Correspondingly, multiple studies have demonstrated that chronic hypoxia depresses vascular contractility through mechanisms that remain to be …

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isoforms in fetal and adult ovine arteries abundance and organization of myosin heavy chain Chronic hypoxia and VEGF differentially modulate

Stacy M. Butler, James Michael Williams, Omid Khorram, William J. Pearce et autres

Maturation Decreases Fractional Activation of Myosin Light Chain Kinase in Ovine Common Carotid Arteries

James Michael Williams, Olayemi Olufikayo Adeoye, William J. Pearce

The present study tests the hypothesis that postnatal changes in contractile protein organization drive changes in MLC20 phosphorylation that contribute to age‐related changes in contractility. In homogenates, MLCK exhibited similar enzyme velocities in fetal and adult ovine carotid arteries. To compare MLCK …

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Chronic Hypoxia Alters the Response of Fetal Ovine Middle Cerebral Arteries to Endothelin‐1 (ET‐1)

Jinjutha Silpanisong, Dahlim Kim, James Michael Williams, Olayemi Olufikayo Adeoye et autres

This study explores the hypothesis that chronic hypoxia alters the expression and intracellular coupling of endothelin receptors to induce phenotypic transformations of smooth muscle cells within the arteries of fetal cerebrovasculature. Endothelium‐denuded middle cerebral arteries (MCAs) harvested from term fetuses of pregnant …

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