Douglas D. Deming

Decreased Glucocorticoid Receptor Expression and Function in Cord Blood Immune Cells from Preterm Neonates with Morbidity

Nana A. O. Anti, Douglas D. Deming, Ciprian P. Gheorghe, Ashra Tugung et autres

Glucocorticoids are essential for fetal organ maturation and form the basis of antenatal corticosteroid therapy that has significantly reduced preterm-related morbidity such as respiratory distress syndrome (RDS). However, neonatal morbidity remains a clinical challenge regardless of antenatal corticosteroid therapy. Currently, it is …

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Perinatal glucocorticoid sensitivity in the preterm newborn: molecular mechanisms, endogenous determinants, and clinical implications

Nana A. O. Anti, Ciprian P. Gheorghe, Douglas D. Deming, Olayemi Olufikayo Adeoye et autres

Glucocorticoids are steroid hormones that regulate multiple physiological processes throughout the lifespan and play a central role in the adaptive stress response. Their biological effects are mediated by the glucocorticoid receptor, which acts through both genomic and nongenomic mechanisms to regulate transcriptional …

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Spiritual Care in the NICU from the Parents’ Perspective: A Mixed Methods Study

Keren Genstler, Alexis Barajas Terrones, Brittany Chow, Kristopher Roxas et autres

Objective: The importance of whole person care interventions is increasingly appreciated in the literature. Spiritual care is one of these dimensions and has been desired by a large percentage of clinical populations in critical care situations. A typical assumption is that spiritual …

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Comparison of Local and Systemic Inflammation During Invasive Versus Noninvasive Ventilation in Rats

Billy C. Wang, R Lion, Michael Avesar, Jonathan A. Abdala et autres

The impact of noninvasive ventilation (NIV) on local and systemic inflammation is poorly characterized, particularly when compared with invasive mechanical ventilation (IMV). We sought to quantify the local and systemic inflammatory response of these 2 respiratory treatments in rats with lipopolysaccharide (LPS)-induced …

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A pilot study on the biochemical effects of repeated administration of 24% oral sucrose vs. 30% oral dextrose on urinary markers of adenosine triphosphate degradation

Danilyn M. Angeles, Danilo S. Boskovic, Douglas D. Deming, Andrew O. Hopper et autres

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Etiologies of apnea of infancy

Daniella K. Ginsburg, Kanwaljeet Maken, Douglas D. Deming, MARK L. WELCH et autres

BACKGROUND: To date there are limited data in the literature to guide the initial evaluation for etiologies of apnea in full-term infants born at greater than or equal to 37 weeks conceptional age (apnea of infancy [AOI]). Pediatricians and pediatric pulmonologists are …

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Oral dextrose reduced procedural pain without altering cellular ATP metabolism in preterm neonates: a prospective randomized trial

Danilyn M. Angeles, Danilo S. Boskovic, John B. C. Tan, Wendy Shih et autres

OBJECTIVE: To examine the effects of 30% oral dextrose on biochemical markers of pain, adenosine triphosphate (ATP) degradation, and oxidative stress in preterm neonates experiencing a clinically required heel lance. STUDY DESIGN: Utilizing a prospective study design, preterm neonates that met study …

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Oxidative Stress Biomarker Decreased in Preterm Neonates Treated With Kangaroo Mother Care

Dorothy Forde, Douglas D. Deming, John B. C. Tan, Raylene M. Phillips et autres

Objective: Due to physiological and metabolic immaturity, prematurely born infants are at increased risk because of maternal separation in many neonatal intensive care units (NICUs). The stress induced from maternal–infant separation can lead to well-documented short-term physiologic instability and potentially lifelong neurological, …

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Referral for Ophthalmology Evaluation and Visual Sequelae in Children With Primary Brain Tumors

Yin Liu, Chenue Abongwa, Stephen Ashwal, Douglas D. Deming et autres

Importance: Visual impairment in children with brain tumors has received limited attention, as most pediatric neuro-oncology clinical trials neither require ophthalmologic evaluation on enrollment nor monitor effects of treatment on visual function during and after treatment. Objective: To investigate ophthalmology referral patterns …

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The Association of Kangaroo Mother Care, Energy Conservation, Procedural Pain, and Bonding in Preterm Neonates

Dorothy Forde, Danilo S. Boskovic, Eileen K. Fry-Bowers, Danilyn M. Angeles et autres

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High Prevalence of Pulmonary Hypertension Complicates the Care of Infants with Omphalocele

Shandee Hutson, Joanne Baerg, Douglas D. Deming, Shawn D. St. Peter et autres

BACKGROUND: Omphalocele is one of the most common abdominal wall defects. Many newborn infants born with omphalocele present with significant respiratory distress at birth, requiring mechanical ventilatory support, and have clinical evidence of pulmonary hypertension. Little information exists on the prevalence of …

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Extended Abstracts: VIIIth Recent Advances in Neonatal Medicine. An International Symposium Honoring Prof. Bo Sun. Würzburg, October 8-10, 2017

Theodore G. Dassios, Anne Greenough, Ourania Kaltsogianni, Katharina Goeral et autres