Monica Colombo

Italian Journal of Anatomy and Embryology - contenuto non piu disponibile

Giovanna Cutrona, Claudio Tripodo, Serena Matis, Monica Colombo et autres

The development and progression of Chronic Lymphocytic Leukemia (CLL) require co-operation of both microenvironment and cytokines. Investigating the IL-23R/IL-23 axis we found that circulating cells of early-stage CLL patients with shorter time-to-treatment (but not of those with a more benign course) expressed …

Asymmetric induction of IL-23R by CpG and IL-15 in proliferative CLL fractions highlights intraclonal heterogeneity in chronic lymphocytic leukemia

Martina Cardillo, Nadia Bertola, Fabiana Ferrero, Rosanna Massara et autres

ABSTRACT Chronic lymphocytic leukemia (CLL) is sustained by complex interactions with the microenvironment, which provides signals for leukemic cell survival and proliferation. Among these, cytokines of the IL-12 family have emerged as relevant regulators of immune responses and tumor biology, yet their …

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Refining Flow Cytometry-based Sorting of Plasma-derived Extracellular Vesicles

Daniele Reverberi, Maria Chiara Ciferri, Nicole Rosenwasser, Alessandro Catino et autres

BACKGROUND: Extracellular vesicles (EVs) are membrane-bound particles crucial for intercellular communication and serve as promising biomarkers for diseases, including cancer. Isolating and characterizing specific EV subpopulations, particularly those in plasma/serum, enhances biomarker precision and supports targeted therapies. Cancer-derived EVs often express unique …

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Butyrate enhances CD56bright NK cell-driven killing of activated T cells and modulates NK cell chromatin accessibility

Federico Carlini, Margherita Squillario, Valentina Casella, Matteo Capaia et autres

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Chronic lymphocytic leukemia often arises by a multiclonal selection process

Davide Bagnara, Andrea Nicola Mazzarello, Niccolò Cardente, Stefano Vergani et autres

Although chronic lymphocytic leukemia (CLL) is diagnosed by identifying a circulating B-cell clone that exceeds 5x103/μL, additional distinct clones (ADC) have been identified in various studies. Notably, the numbers of ADC documented in these studies has increased as the various technologies evolved. …

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JAK2 is a critical therapeutic target in VEXAS syndrome treated with ruxolitinib

Andrea Ceccardi, Martina Dameri, Francesco Ravera, Mario Stabile et autres

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Butyrate modulates the epigenetic landscape of human natural killer cells and affects their regulatory function

Alice Laroni, Federico Carlini, Margherita Squillario, Valentina Casella et autres

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MicroRNA Profiling as a Predictive Indicator for Time to First Treatment in Chronic Lymphocytic Leukemia: Insights from the O-CLL1 Prospective Study

Ennio Nano, Francesco Reggiani, Adriana Amaro, Paola Monti et autres

A “watch and wait” strategy, delaying treatment until active disease manifests, is adopted for most CLL cases; however, prognostic models incorporating biomarkers have shown to be useful to predict treatment requirement. In our prospective O-CLL1 study including 224 patients, we investigated the …

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MicroRNA Profiling as a Predictive Indicator for Time to First Treatment in Chronic Lymphocytic Leukemia: Insights from the O-CLL1 Prospective Study.

Ennio Nano, Francesco Reggiani, Adriana Amaro, Paola Monti et autres

A “watch and wait” strategy, delaying treatment until active disease manifests, is adopted for most CLL cases; however prognostic models incorporating biomarkers have shown to be useful to predict treatment requirement. In our prospective O-CLL1 study including 224 patients, we investigated the …

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Unexpected chronic lymphocytic leukemia B cell activation by bisphosphonates

Andrea Nicola Mazzarello, Elena Gugiatti, Vanessa Cossu, Nadia Bertola et autres

Chronic lymphocytic leukemia (CLL) is a disease of the elderly, often presenting comorbidities like osteoporosis and requiring, in a relevant proportion of cases, treatment with bisphosphonates (BPs). This class of drugs was shown in preclinical investigations to also possess anticancer properties. We …

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Viscoelastic Deformability Cytometry: Ultra-high Throughput Platform for Mechanical Phenotyping of Cells in Liquid and Solid Biopsies

Mohammad H. Asghari, Sarah Duclos Ivetich, Mahmut Kamil Aslan, Morteza Aramesh et autres

Abstract Due to the differences in mechanical properties between cancer cells and their benign counterparts, the mechanical characteristics of cells have emerged as a significant feature in diagnosing cancer. Consequently, measuring cell deformability as a means of mechanical phenotyping is promising for …

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Genes selection using deep learning and explainable artificial intelligence for chronic lymphocytic leukemia predicting the need and time to therapy

Fortunato Morabito, Carlo Adornetto, Paola Monti, Adriana Amaro et autres

Analyzing gene expression profiles (GEP) through artificial intelligence provides meaningful insight into cancer disease. This study introduces DeepSHAP Autoencoder Filter for Genes Selection (DSAF-GS), a novel deep learning and explainable artificial intelligence-based approach for feature selection in genomics-scale data. DSAF-GS exploits the …

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