Unexpected chronic lymphocytic leukemia B cell activation by bisphosphonates
Rattachement africain : it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Chronic lymphocytic leukemia (CLL) is a disease of the elderly, often presenting comorbidities like osteoporosis and requiring, in a relevant proportion of cases, treatment with bisphosphonates (BPs). This class of drugs was shown in preclinical investigations to also possess anticancer properties. We started an in vitro study of the effects of BPs on CLL B cells activated by microenvironment-mimicking stimuli and observed that, depending on drug concentration, hormetic effects were induced on the leukemic cells. Higher doses induced cytotoxicity whereas at lower concentrations, more likely occurring in vivo, the drugs generated a protective effect from spontaneous and chemotherapy-induced apoptosis, and augmented CLL B cell activation/proliferation. This CLL-activation effect promoted by the BPs was associated with markers of poor CLL prognosis and required the presence of bystander stromal cells. Functional experiments suggested that this phenomenon involves the release of soluble factors and is increased by cellular contact between stroma and CLL B cells. Since CLL patients often present comorbidities such as osteoporosis and considering the diverse outcomes in both CLL disease progression and CLL response to treatment among patients, illustrating this phenomenon holds potential significance in driving additional investigations.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Unexpected chronic lymphocytic leukemia B cell activation by bisphosphonates
- Date Crossref
- 27/01/2024
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Genoa Department of Experimental Medicine (DIMES) pays non établi dans la noticeUniversité ou école supérieure
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Ospedale Policlinico San Martino Molecular Pathology Unit pays non établi dans la noticeÉtablissement de santé
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Institute of Molecular Bioimaging and Physiology pays non établi dans la noticeStructure de recherche
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National Research Council pays non établi dans la noticeOrganisation à but non lucratif
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Clinic of Hematology pays non établi dans la noticeÉtablissement de santé
Department of Experimental Medicine (DIMES) — University of Genoa, Molecular Pathology Unit — Ospedale Policlinico San Martino et Institute of Molecular Bioimaging and Physiology, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.