Discovery of Tcf7 regulators with clonally-resolved CRISPR screens identifies Trim28 as a mediator of CD8 T cell differentiation in tumors
Marc A. Schwartz, Dillon Lue, Mohammed Mutaher, Miriam McNerney et autres
Abstract Stem-like TCF7+ CD8 T cells sustain anti-tumor responses and support immune checkpoint blockade. We systematically identified regulators of this cell state using genome-wide CRISPR screens in primary T cells in vitro . Using random barcodes to link clonal relationships with guide …
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bioRxiv (Cold Spring Harbor Laboratory)