Christa K. McIntyre

Post-stress modulation of the HPA and melanocortin systems alleviates migraine-like behaviors in mice

Ya-Yu Hu, Hao‐Ruei Mei, Abbas Pirwani, Armen N. Akopian et autres

BackgroundStress is a major trigger for migraine attacks. Stress activates the hypothalamic-pituitary-adrenal (HPA) axis, releasing glucocorticoids (GCs) to maintain homeostasis, and migraine attacks may occur as an adverse effect of this response. We previously demonstrated in a mouse model that inhibiting corticosterone …

us (code pays fourni par la source)

Vagus nerve stimulation rescues impaired fear extinction and social interaction in a rat model of autism spectrum disorder

Amanda C. Alvarez-Dieppa, Kimberly Griffin, Sheridan Cavalier, Rimenez Rodrigues de Souza et autres

Clinical diagnosis of anxiety disorders is highly prevalent in autism spectrum disorders (ASD). Available treatments for anxiety offer limited efficacy in the ASD population. Vagus nerve stimulation (VNS) has an anxiolytic effect in rats and, when coupled with fear extinction training, VNS …

us (code pays fourni par la source)

Optogenetic inhibition of the locus coeruleus blocks vagus nerve stimulation-induced enhancement of extinction of conditioned fear in rats

Debora R Calderon-Williams, Rimenez Rodrigues de Souza, Ching-Jiunn Tseng, Hervé Abdi et autres

Vagus nerve stimulation (VNS) is a therapeutic intervention previously shown to enhance fear extinction in rats. VNS is approved for use in humans for the treatment of epilepsy, depression, and stroke, and it is currently under investigation as an adjuvant to exposure …

us (code pays fourni par la source)

Glucocorticoid signaling mediates stress-induced migraine-like behaviors in a preclinical mouse model

Ya-Yu Hu, Rimenez Rodrigues de Souza, Athithyaa Muthuraman, Leela Knapp et autres

BACKGROUND: Stress is one of the most common precipitating factors in migraine and is identified as a trigger in nearly 70% of patients. Responses to stress include release of glucocorticoids as an adaptive mechanism, but this may also contribute to migraine attacks. …

us (code pays fourni par la source)

Normative telecommuting: the effects of group composition and task interdependence on telecommuter and non-telecommuter performance

Mark Podolsky, Mary Jo Ducharme, Christa K. McIntyre

Purpose This study examines whether group-level homogeneity in telecommuting status is associated with performance differences between teleworkers and non-teleworkers at the individual level. The authors further investigate the impact of group-level task interdependence on this relationship. Design/methodology/approach A group of 225 employees …

ca (code pays fourni par la source)

Timing of vagus nerve stimulation during fear extinction determines efficacy in a rat model of PTSD

Rimenez Rodrigues de Souza, Mark B. Powers, Robert L. Rennaker, Christa K. McIntyre et autres

Studies have indicated that vagus nerve stimulation (VNS) enhances extinction learning in rodent models. Here, we investigated if pairing VNS with the conditioned stimulus is required for the enhancing effects of VNS. Adult Sprague-Dawley rats were exposed to intense stress followed by …

us (code pays fourni par la source)

Vagus Nerve Stimulation as a Treatment for Fear and Anxiety in Individuals with Autism Spectrum Disorder

Tanushree Shivaswamy, Rimenez Rodrigues de Souza, Crystal T. Engineer, Christa K. McIntyre

Anxiety disorders affect a large percentage of individuals who have an autism spectrum disorder (ASD). In children with ASD, excessive anxiety is also linked to gastrointestinal problems, self-injurious behaviors, and depressive symptoms. Exposure-based cognitive behavioral therapies are effective treatments for anxiety disorders …

us (code pays fourni par la source)

Daily Optogenetic Stimulation of the Left Infralimbic Cortex Reverses Extinction Impairments in Male Rats Exposed to Single Prolonged Stress

Lucas Canto‐de‐Souza, Peyton G. Demetrovich, Samantha L. Plas, Rimenez Rodrigues de Souza et autres

Post-traumatic stress disorder (PTSD) is associated with decreased activity in the prefrontal cortex. PTSD-like pathophysiology and behaviors have been observed in rodents exposed to a single prolonged stress (SPS) procedure. When animals are left alone for 7 days after SPS treatment, they …

us, br (code pays fourni par la source)

Post-training intra-basolateral complex of the amygdala infusions of clenbuterol enhance memory for conditioned place preference and increase ARC protein expression in dorsal hippocampal synaptic fractions

Jayme R. McReynolds, María B. Carreira, Christa K. McIntyre

us (code pays fourni par la source)

Amygdala-hippocampal interactions in synaptic plasticity and memory formation

Rafael Roesler, Marise B. Parent, Ryan T. LaLumiere, Christa K. McIntyre

br, us (code pays fourni par la source)

Systematic Review and Methodological Considerations for the Use of Single Prolonged Stress and Fear Extinction Retention in Rodents

Chantelle Ferland‐Beckham, Lauren E. Chaby, Nikolaos P. Daskalakis, Dayan Knox et autres

Posttraumatic stress disorder (PTSD) is a mental health condition triggered by experiencing or witnessing a terrifying event that can lead to lifelong burden that increases mortality and adverse health outcomes. Yet, no new treatments have reached the market in two decades. Thus, …

us (code pays fourni par la source)

Vagus nerve stimulation enhances fear extinction as an inverted-U function of stimulation intensity

Rimenez Rodrigues de Souza, Nicole M. Robertson, Christa K. McIntyre, Robert L. Rennaker et autres

us (code pays fourni par la source)