Daily Optogenetic Stimulation of the Left Infralimbic Cortex Reverses Extinction Impairments in Male Rats Exposed to Single Prolonged Stress
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Le résumé fourni par la source
Post-traumatic stress disorder (PTSD) is associated with decreased activity in the prefrontal cortex. PTSD-like pathophysiology and behaviors have been observed in rodents exposed to a single prolonged stress (SPS) procedure. When animals are left alone for 7 days after SPS treatment, they show increased anxiety-like behavior and impaired extinction of conditioned fear, and reduced activity in the prefrontal cortex. Here, we tested the hypothesis that daily optogenetic stimulation of the infralimbic region (IL) of the medial prefrontal cortex (mPFC) during the 7 days after SPS would reverse SPS effects on anxiety and fear extinction. Male Sprague-Dawley rats underwent SPS and then received daily optogenetic stimulation (20 Hz, 2 s trains, every 10 s for 15 min/day) of glutamatergic neurons of the left or right IL for seven days. After this incubation period, rats were tested in the elevated plus-maze (EPM). Twenty-four hours after the EPM test, rats underwent auditory fear conditioning (AFC), extinction training and a retention test. SPS increased anxiety-like behavior in the EPM task and produced a profound impairment in extinction of AFC. Optogenetic stimulation of the left IL, but not right, during the 7-day incubation period reversed the extinction impairment. Optogenetic stimulation did not reverse the increased anxiety-like behavior, suggesting that the extinction effects are not due to a treatment-induced reduction in anxiety. Results indicate that increased activity of the left IL after traumatic experiences can prevent development of extinction impairments. These findings suggest that non-invasive brain stimulation may be a useful tool for preventing maladaptive responses to trauma.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Daily Optogenetic Stimulation of the Left Infralimbic Cortex Reverses Extinction Impairments in Male Rats Exposed to Single Prolonged Stress
- Date Crossref
- 20/12/2021
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The University of Texas at Dallas Texas Biomedical Device Center pays non établi dans la noticeUniversité ou école supérieure
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Instituto de Neurociências e Comportamento pays non établi dans la noticeOrganisation à but non lucratif
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Centro Universitário de Araraquara pays non établi dans la noticeUniversité ou école supérieure
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Universidade Estadual Paulista (Unesp) pays non établi dans la noticeUniversité ou école supérieure
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Texas Biomedical Research Institute pays non établi dans la noticeStructure de recherche
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University of Iowa Department of Psychological and Brain Sciences pays non établi dans la noticeUniversité ou école supérieure
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Universidade Federal de São Carlos Joint Graduate Program in Physiological Sciences pays non établi dans la noticeUniversité ou école supérieure
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Institute of Neuroscience and Behavior pays non établi dans la noticeStructure de recherche
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School of Pharmaceutical Sciences Laboratory of Pharmacology pays non établi dans la noticeUniversité ou école supérieure
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School of Behavior and Brain Sciences pays non établi dans la noticeUniversité ou école supérieure
Texas Biomedical Device Center — The University of Texas at Dallas, Instituto de Neurociências e Comportamento et Centro Universitário de Araraquara, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.