Accès ouvert
2026
article
OpenAlex
Jeffrey R. Maslanka, Qianxuan She, Kathleen S Krauss, Emily Nicole Bitsko et autres
The gastrointestinal pathogen Clostridioides difficile is a major burden for health systems due to high rates of recurrence. C. difficile pathogenesis is mediated by two virulence factors, toxin A (TcdA) and toxin B (TcdB). Antibodies specific for TcdA and TcdB are correlated …
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Accès ouvert
2026
article
OpenAlex
Jennifer A. Londregan, Isaiah Rozich, Brian T. Gaudette, Jeffrey R. Maslanka et autres
Marginal zone (MZ) B cells are hyperresponsive to bacterial Toll-like Receptor (TLR) ligands. However, the full extent of TLR responsiveness for MZ B cells and the mechanisms regulating such responses are unclear. We report that Notch2 activation establishes MZ B cell responsiveness …
us
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Accès ouvert
2026
preprint
OpenAlex
Jeffrey R. Maslanka, Qianxuan She, Kathleen S Krauss, Emily N. Konopka et autres
Abstract The gastrointestinal pathogen Clostridioides difficile , is a major burden for health systems due to high rates of recurrence. C. difficile pathogenesis is mediated by two virulence factors, toxin A (TcdA) and Toxin B (TcdB). Antibodies specific for TcdA and TcdB …
us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan et autres
Vaccine approaches capable of eliciting enhanced germinal center (GC) responses would result in improved protective humoral immunity against infectious diseases. Here, we investigate whether a cytokine can be scaffolded onto a self-assembling nanoparticle immunogen to enhance antigen-specific GC responses and B cell …
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Accès ouvert
2025
article
OpenAlex
Jennifer A. Londregan, Isaiah Rozich, Brian T. Gaudette, Nicholas J. Tursi et autres
Abstract Description The efficiency with which B cells respond to activation signals varies by subset. Whereas marginal zone (MZ) B cells exhibit rapid activation following stimulation, follicular (FO) B cells adopt delayed effector programs. MZ B cells uniquely exhibit readiness for the …
us
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Accès ouvert
2025
article
OpenAlex
Jeffrey R. Maslanka, Jennifer A. Londregan, Joshua E. Denny, F. Christopher Peritore et autres
Abstract Description Clostridioides difficile colonizes the gastrointestinal tract and secretes two major virulence factors: toxin A (TcdA) and toxin B (TcdB). Protective immunity to C. difficile infection is limited as patients are susceptible to severe recurrent infections, often by the same strain …
us
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Accès ouvert
2025
article
OpenAlex
Isaiah Rozich, Brian T. Gaudette, Jennifer A. Londregan, David A. Allman
Abstract Description During a recall immune response, memory B cells differentiate into plasma cells (PCs), which are indispensable for antibody production and humoral immunity. Furthermore, memory B cells proliferate sooner and require less stimulation to differentiate into PCs relative to naïve B …
us
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Accès ouvert
2025
article
OpenAlex
Jeffrey R. Maslanka, Jennifer A. Londregan, Joshua E. Denny, Ellie N Hulit et autres
Clostridioides difficile colonizes the gastrointestinal tract and secretes two virulence factors: toxin A (TcdA) and toxin B (TcdB). Protective immunity against C. difficile infection is limited as patients are susceptible to multiple rounds of recurrent infections. The factors determining whether immunity to …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Jeffrey R. Maslanka, Jennifer A. Londregan, Joshua E. Denny, Ellie N Hulit et autres
Abstract Clostridioides difficile colonizes the gastrointestinal tract and secretes two virulence factors: toxin A (TcdA) and toxin B (TcdB). Protective immunity against C. difficile infection is limited as patients are susceptible to multiple rounds of recurrent infections. The factors determining whether immunity …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Nicholas J. Tursi, Sachchidanand Tiwari, Nicole M. Bedanova, Toshitha Kannan et autres
T cell responses relative to mRNA-LNPs or adjuvanted protein, with memory responses persisting beyond one year. In rabbits immunized with HA DNA-LNP, we observed immune responses comparable or superior to mRNA-LNPs at the same dose. In an additional model, a SARS-CoV-2 spike-encoding …
us
(code pays fourni par la source)
2024
conference-abstract
OpenAlex
Jennifer A. Londregan, Brian T. Gaudette, Francesca Galli, Nicholas J. Tursi et autres
Abstract The efficiency with which B cells respond to activation signals varies depending on the subset. Whereas marginal zone (MZ) B cells exhibit rapid activation kinetics following stimulation, follicular (FO) B cells adopt delayed effector programs. Further, MZ B cells uniquely exhibit …
us
(code pays fourni par la source)
2024
conference-abstract
OpenAlex
Nicholas J. Tursi, Toshitha Kannan, Jennifer A. Londregan, Katlyn Lederer et autres
Abstract An alluring strategy for improving protective humoral immunity against infectious diseases would be to directly target the germinal center (GC). Robust GC responses are associated with high titer and high affinity antibody responses. Despite advances in formulation strategies and vaccine design, …
us
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