Conor N Robinson

Complementary frontoparietal and corticothalamic contributions to relational reasoning

Conor N Robinson, Luke J. Hearne, Kartik K. Iyer, Takuya Ito et autres

ABSTRACT Complex reasoning requires frontal, parietal, and thalamic systems to manage increasing relational demands, yet the underlying circuit mechanisms remain unclear. Here, we combined EEG with biologically grounded corticothalamic neural field modelling while participants solved relational problems of graded complexity. Successful reasoning …

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Aligning transformer circuit mechanisms to neural representations in relational reasoning

Luke J. Hearne, Conor N Robinson, Luca Cocchi, Takuya Ito

Relational reasoning, the capacity to understand how elements relate to one another, is a defining feature of human intelligence, yet its computational basis remains unclear. Here, we combined human neuroimaging (7T fMRI) with artificial neural network modeling to identify circuit-level analogues of …

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Mechanisms and interventions promoting healthy frontostriatal dynamics in obsessive-compulsive disorder

Sébastien Naze, Luke J. Hearne, Paula Sanz‐Leon, Conor N Robinson et autres

Changes in the frontostriatal system activity support individuals' perseverance in distressful thoughts and rigid, repetitive behaviours that define obsessive-compulsive disorder (OCD). Converging evidence from preclinical and clinical work suggests that OCD maps onto a functional imbalance in the ventral and dorsal frontostriatal …

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Altered Striatal Functional Gradients in Obsessive-Compulsive Disorder

Lachlan Webb, Luke J. Hearne, Ye Tian, Andrew Zalesky et autres

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Altered striatal functional gradients in obsessive-compulsive disorder

Lachlan Webb, Luke J. Hearne, Ye Tian, Andrew Zalesky et autres

Background: Obsessive-compulsive disorder (OCD) is associated with functional alterations in how the striatum interacts with the rest of the brain. However, the characterization of these changes in OCD is incomplete. Mapping functional striatal gradients provides a new opportunity to fill this knowledge …

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Relational Integration Demands Are Tracked by Temporally Delayed Neural Representations in Alpha and Beta Rhythms Within Higher‐Order Cortical Networks

Conor N Robinson, Luca Cocchi, Takuya Ito, Luke J. Hearne

Relational reasoning is the ability to infer and understand the relations between multiple elements. In humans, this ability supports higher cognitive functions and is linked to fluid intelligence. Relational complexity (RC) is a cognitive framework that offers a generalisable method for classifying …

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Precision TMS in Major Depressive Disorder: An Open-Label Trial of Personalized TMS

Luke J. Hearne, Lachlan Webb, Robin F. H. Cash, Conor N Robinson et autres

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Clinical and Neurophysiological Effects of Robotically Delivered fMRI-Guided Personalized Transcranial Magnetic Stimulation Therapy for Depression

Luke J. Hearne, Lachlan Webb, Robin F. H. Cash, Conor N Robinson et autres

INTRODUCTION: Repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) is an established treatment for refractory major depressive disorder (MDD), but treatment outcomes vary substantially from person to person. Recent evidence suggests that incorporating neuroimaging-based targeting may help improve …

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Relational integration demands are tracked by temporally delayed neural representations in alpha and beta rhythms within higher-order cortical networks

Conor N Robinson, Luca Cocchi, Takuya Ito, Luke J. Hearne

Relational reasoning is the ability to infer and understand the relations between multiple elements. In humans, this ability supports higher cognitive functions and is linked to fluid intelligence. Relational complexity (RC) is a cognitive framework that offers a generalisable method for classifying …

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Brain signatures of chronic gut inflammation

Caitlin Victoria Hall, Graham L Radford‐Smith, Emma J. Savage, Conor N Robinson et autres

Gut inflammation is thought to modify brain activity and behaviour via modulation of the gut-brain axis. However, how relapsing and remitting exposure to peripheral inflammation over the natural history of inflammatory bowel disease (IBD) contributes to altered brain dynamics is poorly understood. …

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Revisiting deficits in threat and safety appraisal in obsessive‐compulsive disorder

Luke J. Hearne, Michael J Breakspear, Ben J. Harrison, Caitlin Victoria Hall et autres

Abstract Current behavioural treatment of obsessive‐compulsive disorder (OCD) is informed by fear conditioning and involves iteratively re‐evaluating previously threatening stimuli as safe. However, there is limited research investigating the neurobiological response to conditioning and reversal of threatening stimuli in individuals with OCD. …

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Effects of transcranial magnetic stimulation of the rostromedial prefrontal cortex in obsessive–compulsive disorder: a randomized clinical trial

Luca Cocchi, Sébastien Naze, Conor N Robinson, Lachlan Webb et autres

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