Luntao Liu

PCET‐Inspired Nanoparticles Enable Paired Proton‐Electron Delivery to Restore Mitochondrial Electron Transport and Regenerate Bone During Aging

Kelei Wang, Xiayu Hu, Changfen Bi, Yimai Zhuang et autres

Mitochondrial electron transport chain (ETC) dysfunction drives the accumulation of damaged mitochondria and bioenergetic insufficiency, contributing to cellular senescence and impaired tissue repair in aging. However, reconstituting ETC-associated mitochondrial bioenergetics in situ to overcome this energy restriction remains challenging. In this study, …

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Multistage Biobarrier-Adaptive Peptide Radiosensitizer with Low-Dose X-ray Augments Glioblastoma Radiotherapy via Destabilizing Lysosomal Homeostasis

Xueyin Hu, Wei Cheng, Jun Che, Yuanfang Chen et autres

Glioblastoma (GBM) radiotherapy is hampered by intrinsic radioresistance. Current radiosensitizers face two unresolved hurdles: inability to dynamically traverse sequential physiological barriers of GBM and lack of multitargeted action against the pathways driving radioresistance. Here, we developed h-Pep-MTZ, a biobarrier-adaptive peptide-radiosensitizer addressing both. …

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Efficient active hydrogen delivery for drug-free radiation enteritis therapy in mice

Changfen Bi, Yuanfang Chen, Xueyin Hu, Shuqin Li et autres

Radiation enteritis, affecting over 90% of pelvic/abdominal radiotherapy patients, is primarily caused by radiation-induced reactive oxygen and nitrogen species (RONS). Active hydrogens, with broad-spectrum RONS scavenging ability, show radioprotective potential but face delivery challenges due to the intestinal mucus barrier and short …

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Understanding the toxicity induced by radiation-triggered neuroinflammation and the on-demand design of targeted peptide nanodrugs

Yue Shang, Xueyin Hu, Meixia Ren, Longbo Ma et autres

Abstract Radiation-induced brain injury (RIBI) represents a severe complication of cranial radiotherapy, substantially diminishing patients’ quality of life. Unlike conventional brain injuries, RIBI evokes a unique chronic neuroinflammatory response that notably aggravates neurodegenerative processes. Despite significant progress in understanding the molecular mechanisms …

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Harnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy

Wen Zhang, Xueyin Hu, Wei Cheng, Lumeng Zhang et autres

Abstract The tumor microenvironment (TME) plays a crucial role in cancer progression and treatment, particularly in the field of immunotherapy. Composed of diverse cell types and extracellular matrix components, the TME collectively contributes to cancer pathogenesis and resistance to treatment. In recent …

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Molecular Engineering of Direct Activated NIR-II Chemiluminescence Platform for In Vivo Chemiluminescence-fluorescence Duplex Imaging

Zhongxiang Chen, Qian Li, Ying Wu, Jian‐Yong Liu et autres

Chemiluminescence (CL) is a self-illuminating phenomenon fueled by chemical energy instead of extra excited light, which features superiority in sensitivity, signal-to-background ratios, and imaging depth. Strategies to synthesize a CL emission unimolecular skeleton in the second near-infrared window (NIR-II) and a unimolecular …

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A General Strategy for Tumor-Specific In Situ Synthesis of Copper Sulfide for Gas Therapy and Surface Plasmon Resonance Enhanced Phototherapy

Wei Cheng, Ying Wu, Bowen Li, Lichao Su et autres

CuS nanomaterials have attracted much attention for tumor therapy because of their excellent photothermal and photodynamic properties. Notably, Cu 2 O can be converted in situ to CuS through sulfurization by H 2 S in tumor cells. However, this approach is currently …

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Efficient active hydrogen delivery for drug-free radiation enteritis therapy

Luntao Liu, X. Yin, Changfen Bi, Yuanfang Chen et autres

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Regulatory T Cells and Their Derived Cell Pharmaceuticals as Emerging Therapeutics Against Autoimmune Diseases

Yu Liu, Yiqiu Fu, Rourou Miao, Jiahui Cao et autres

Abstract Caused by the loss in the tolerance against self‐antigens, autoimmune diseases are chronic disorders that impact millions of individuals annually with significant economic burden. They are triggered by a deficiency in the quantity or function of regulatory T (Treg) cells, which …

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Biomimetic Self‐Propelled Asymmetric Nanomotors for Cascade‐Targeted Treatment of Neurological Inflammation

Jiamin Ye, Yueyue Fan, Yaoguang She, Jiacheng Shi et autres

Abstract The precise targeted delivery of therapeutic agents to deep regions of the brain is crucial for the effective treatment of various neurological diseases. However, achieving this goal is challenging due to the presence of the blood‒brain barrier (BBB) and the complex …

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Reversible assembled gelatin aerogel-based phase change materials for light-to-thermal conversion and management

Shuqin Li, Wen Zhang, Longfei Zhou, Xueyin Hu et autres

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Engineering nanosystems for ROS-bridged cancer cascade therapy

Qinrui Fu, Leilei Yu, Meihua Zhang, Shuqin Li et autres

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