Accès ouvert
2026
article
OpenAlex
Xiaocheng Peng, Ziyi Wang, Jia Si, Hongsheng Ji et autres
Background: Chronic kidney disease (CKD) is a prevalent condition associated with an increased risk of renal cell carcinoma (RCC). However, the molecular mechanisms underlying the link between CKD and RCC remain largely unexplored. This study aimed to identify key biomarkers and molecular …
cn, us
(code pays fourni par la source)
2025
article
OpenAlex
Xueyin Hu, Wei Cheng, Jun Che, Yuanfang Chen et autres
Glioblastoma (GBM) radiotherapy is hampered by intrinsic radioresistance. Current radiosensitizers face two unresolved hurdles: inability to dynamically traverse sequential physiological barriers of GBM and lack of multitargeted action against the pathways driving radioresistance. Here, we developed h-Pep-MTZ, a biobarrier-adaptive peptide-radiosensitizer addressing both. …
cn, sg
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Changfen Bi, Yuanfang Chen, Xueyin Hu, Shuqin Li et autres
Radiation enteritis, affecting over 90% of pelvic/abdominal radiotherapy patients, is primarily caused by radiation-induced reactive oxygen and nitrogen species (RONS). Active hydrogens, with broad-spectrum RONS scavenging ability, show radioprotective potential but face delivery challenges due to the intestinal mucus barrier and short …
cn
(code pays fourni par la source)
2025
article
OpenAlex
Yuanfang Chen, Min Deng, Yan Shi, Lishuang Sun et autres
Accurately assessing the risk level of areas where infectious cases have previously been active is critical for screening potential infectious cases and mitigating the epidemic. Current studies generally regard activity areas recorded in data as risk areas, and assessed the risks by …
cn
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Wen Zhang, Xueyin Hu, Wei Cheng, Lumeng Zhang et autres
Abstract The tumor microenvironment (TME) plays a crucial role in cancer progression and treatment, particularly in the field of immunotherapy. Composed of diverse cell types and extracellular matrix components, the TME collectively contributes to cancer pathogenesis and resistance to treatment. In recent …
cn, sg, us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Yuanfang Chen, Andong Li, Yizhou Yang, Jing Lu et autres
BACKGROUND: HIV/AIDS persists as a global health challenge despite significant advancements in antiretroviral therapy (ART). The transformation of HIV into a chronic condition, coupled with regional disparities and evolving epidemiological trends, necessitates an updated analysis of the disease burden. METHODS: We conducted …
cn
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Jia-ming Yang, Haikang Tang, Yuanfang Chen, Ze Bo Hu et autres
The aryl hydrocarbon receptor (AHR) is a versatile transcription factor, that responds to a diverse array of both exogenous and endogenous ligands. Broccoli consumption was shown to alter the microbiota, and attenuate chemically induced colitis in mice through AhR-dependent pathway. The study …
cn
(code pays fourni par la source)
2025
conference-paper
OpenAlex
Siyong Lu, Yuanfang Chen
As malicious software continues to proliferate at an unprecedented rate and digital devices become increasingly integral to everyday activities, malware detection has becoming more and more important. The traiditional signature-based detection method has already been widely used. However, these rules are becoming …
cn
(code pays fourni par la source)
2025
conference-paper
OpenAlex
Yuanfang Chen, Siyong Lu, JinLiang Xue
Binary code similarity detection is a technique that analyzes the semantic and structural features of binary code, compares it with known vulnerable code for similarity, and determines whether the tested code contains vulnerabilities. With the increasing complexity of firmware vulnerabilities in IoT …
cn
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Hang Zhang, Yinnong Jia, Yuanfang Chen, Luna Wang et autres
High lead (Pb) burden in humans disrupts bone homeostasis and can induce osteoporosis. Here, we report that osteoclast-derived exosomes (OC-Exos) were enriched in the plasma of patients with low bone mineral density and Pb exposure. Osteoclasts (OCs) secrete microRNA-enriched exosomes, through which …
cn
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Yuanfang Chen, Sihang Ma, Xing Fang
In traffic cyber-physical systems, accurately tracking the movements of surrounding objects is crucial for the safety and reliability of autonomous vehicles. In these safetycritical scenarios, physical adversarial attacks present a significant threat. Existing attack methods primarily rely on global perturbations, which are …
cn
(code pays fourni par la source)
2024
preprint
OpenAlex
Xuanyu Nan, Yujie Li, Rui Zhang, Ruoke Wang et autres
Abstract The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its Omicron subvariants drastically amplifies transmissibility, infectivity, and immune escape, mainly due to their resistance to most neutralizing antibodies. Thus, exploring the mechanisms underlying antibody evasion is crucial. Although the …
cn, gb
(code pays fourni par la source)