PCET‐Inspired Nanoparticles Enable Paired Proton‐Electron Delivery to Restore Mitochondrial Electron Transport and Regenerate Bone During Aging
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Le résumé fourni par la source
Mitochondrial electron transport chain (ETC) dysfunction drives the accumulation of damaged mitochondria and bioenergetic insufficiency, contributing to cellular senescence and impaired tissue repair in aging. However, reconstituting ETC-associated mitochondrial bioenergetics in situ to overcome this energy restriction remains challenging. In this study, a mitochondrial hydrogen-supply system (EMHS) is developed that attenuates senescence-associated phenotypes in the aged bone regenerative niche and promotes skeletal healing in aging via proton-coupled electron transfer (PCET). It has been demonstrated that the active hydrogen generated by EMHS infiltrates mitochondria in senescent cells, enabling the paired delivery of proton-electron equivalents to restore ETC function. This mitochondrial functional recovery is accompanied by reduced mitochondrial reactive oxygen species (ROS) and improved oxidative phosphorylation (OXPHOS) capacity, which expands the functional mitochondrial pool. EMHS restores the osteogenic potential of bone marrow mesenchymal stem cells (BMSCs), enhances endothelial angiogenic capacity, and biases neutrophils toward a pro-repair phenotype. Remarkably, following systemic administration, EMHS preferentially accumulates in bone and promotes bone-vascular coupled regeneration in aged mice with bone defects. Overall, our findings introduce a small-molecule drug-free nanotherapeutic strategy that maintains a functional mitochondrial pool with potential to alleviate cellular aging and age-related diseases.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- PCET‐Inspired Nanoparticles Enable Paired Proton‐Electron Delivery to Restore Mitochondrial Electron Transport and Regenerate Bone During Aging
- Date Crossref
- 20/07/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Second Affiliated Hospital of Zhejiang University pays non établi dans la noticeÉtablissement de santé
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Zhejiang University pays non établi dans la noticeUniversité ou école supérieure
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Chinese Academy of Medical Sciences & Peking Union Medical College pays non établi dans la noticeUniversité ou école supérieure
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Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province Hangzhou P. R. China pays non établi dans la noticeStructure de recherche
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Peking Union Medical College Tianjin P. R. China State Key Laboratory of Advanced Medical Materials and Devices Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine Tianjin Institutes of Health Science Institute of Radiation Medicine Chinese Academy of Medical Sciences & pays non établi dans la noticeUniversité ou école supérieure
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State Key Laboratory of Transvascular Implantation Devices Hangzhou P. R. China pays non établi dans la noticeStructure de recherche
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Clinical Research Center of Motor System Disease of Zhejiang Province Hangzhou P. R. China pays non établi dans la noticeStructure de recherche
Second Affiliated Hospital of Zhejiang University, Zhejiang University et Chinese Academy of Medical Sciences & Peking Union Medical College, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.