Kai Breuhahn

Cancer-driver-agnostic targeting of amplified surface proteins identifies MPZL1 for selective CAR-T cell therapy

Sonia Jimenez-vazquez, Anna Berthel, Christos Patsis, Mara Mitstorfer et autres

Most cancer therapies target genetic alterations driving tumor growth, but many drivers are undruggable or rare, limiting their therapeutic reach. Here, we demonstrate that amplified genes encoding cell surface proteins provide a rich, cancer-driver-agnostic source of targets. We identify MPZL1 (myelin protein …

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Kaiso Is a Novel TAZ-Interaction Partner That Promotes Hepatic Stellate Cell Activation and Regulates the Downstream lncRNA HIF1A-AS3

Amira Khaled Abdelhamid, Fabiola Pedrini, Jennifer Schmitt, Ibrahim Hassan Fayed et autres

Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are key regulators of hepatic stellate cell (HSC) activation and liver fibrosis. While the canonical YAP/TAZ-TEAD axis is well-characterized, non-canonical interaction partners and downstream long non-coding RNAs (lncRNAs) that orchestrate fibrogenic programs …

Égypte, de (code pays fourni par la source)

NUP153 immunoreactivity in neuroendocrine neoplasms supports the diagnosis of NET versus NEC and is modulated by post‐translational modifications

Sven Mattern, Arslan Ali, Vanessa Hollfoth, Eyyub Bag et autres

Nucleoporins (NUPs) constitute the nuclear pore complex (NPC) and are essentially involved in nuclear transport, chromatin organization, and context-dependent gene regulation. However, the role of NUPs in neuroendocrine (tumor)biology and related diagnostic potential is poorly defined. In this study, we comparatively analyzed …

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A Serum lncRNA Signature Determines Oncogenic YAP Activity in Cancer Patients

Fabian Rose, Nada El-Ekiaby, Lilija Wehling, Sofia M.E. Weiler et autres

Biomarkers are typically identified by comparing human samples such as tissues and serum. However, reliable markers for transcriptionally active oncogenes remain elusive due to tumor heterogeneity and confounding signals from non-tumorous cells. We hypothesize that in vitro screening is sufficient to identify …

de, Égypte (code pays fourni par la source)

FRI-305 The YAP/TAZ-regulated long non-coding RNA SNHG16 promotes hepatic stellate cell activation

Amira Abdelhamid, Aya Osama, Hannah Rashwan, Ibrahim Fayed et autres

Characteristic histopathology of phenprocoumon-induced liver injury: correlation with clinical presentation and outcome

Beate K. Straub, V. Dries, Kai Breuhahn, H. U. Kasper et autres

Phenprocoumon (PPC) was for a long time one of the most frequently used oral anticoagulant drugs in continental Europe and is still used for certain indications. We retrospectively analysed clinical presentation and liver histology of 29 PPC-patients with hepatic disease of unknown …

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Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis.

Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, A Krumme et autres

Aberrant Notch signaling has been identified as a key driver of cancer development. Genetic studies in Drosophila showed that the knockout of strawberry notch (sno) mimics the loss of notch. Here, we found that Strawberry Notch 1 (SBNO1) is upregulated in several …

Pilot study: predicting the interplay between FOXO1 and its downstream long non-coding RNAs in HCC

Rowan Abdelbary, S. Saber, Fabian Rose, Kai Breuhahn et autres

Introduction Forkhead Box O-1 ( FOXO1 ) is one of the key regulatory transcription factors capable of regulating many critical cellular functions, such as promoting apoptosis and inhibiting cell cycle progression thereby acting as a tumor-suppressor. In hepatocellular carcinoma (HCC), FOXO1 has …

République démocratique du Congo, Égypte, de (code pays fourni par la source)

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, A Krumme et autres

Aberrant Notch signaling has been identified as a key driver of cancer development. Genetic studies in Drosophila showed that the knockout of strawberry notch (sno) mimics the loss of notch. Here, we found that Strawberry Notch 1 (SBNO1) is upregulated in several …

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Activated ATF6α is a hepatic tumour driver restricting immunosurveillance

Xin Li, Cynthia Lebeaupin, Aikaterini Kadianaki, Clementine Druelle-Cedano et autres

Abstract Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality and there are limited therapies 1 . Although endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are implicated in HCC, the involvement of the UPR transducer ATF6α remains …

de, us, es, ch, cn (code pays fourni par la source)

Comparative Analysis of TEAD Inhibitor Efficacy in Hepatocellular Carcinoma Cells

K G Mau, Michaela Bissinger, S Savchenko, Ariane Neumann et autres

Hepatocellular carcinomas (HCC) are a major health concern, surpassing already today half a million deaths each year. HCCs are prone to rapidly develop resistance against common anti-cancer drugs, thereby strongly limiting suitable treatment regimens and therefore warranting the need for novel drugs. …

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The Cell Polarity Protein MPP5/PALS1 Controls the Subcellular Localization of the Oncogenes YAP and TAZ in Liver Cancer

Marcell Tóth, Shan Wan, Jennifer Schmitt, P. Birner et autres

The oncogenes yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are potent liver oncogenes. Because gene mutations cannot fully explain their nuclear enrichment, we aim to understand which mechanisms cause YAP/TAZ activation in liver cancer cells. The combination of proteomics …

at, de, cn (code pays fourni par la source)