Keunsoo Kang

Transcriptome-based epigenetic screening identifies DNA hypermethylation signatures as prognostic biomarkers in oral squamous cell carcinoma

Yu Kyeong Han, Jihye Park, Hye Su Han, Keunsoo Kang et autres

Promoter DNA hypermethylation is a key epigenetic mechanism of gene silencing in cancer, yet the DNA hypermethylome of oral squamous cell carcinoma (OSCC) and its prognostic relevance remain poorly characterized. Here, we systematically identified and validated novel hypermethylated genes with prognostic significance …

kr (code pays fourni par la source)

Flavobacterium eburneum sp. nov., isolated from reclaimed saline land soil

Woon Mo Hwang, Dohak Kim, Keunsoo Kang, Tae‐Young Ahn

This dataset contains the digitized treatments in Plazi based on the original journal article Hwang, Woon Mo, Kim, Dohak, Kang, Keunsoo, Ahn, Tae-Young (2017): Flavobacterium eburneum sp. nov., isolated from reclaimed saline land soil. International Journal of Systematic and Evolutionary Microbiology 67 …

BRAID: RT-PCR-calibrated conformal intervals for splicing ΔPSI

Jihye Park, Keunsoo Kang

Abstract Differential splicing workflows usually report a ΔPSI point estimate and a statistical score, but these outputs do not directly state whether the RNA-seq estimate is close enough to an orthogonal validation measurement. We developed BRAID as a post-processing calibration step for …

kr (code pays fourni par la source)

Aberrant 3′UTR splicing drives FUS-dependent mRNA condensates and prevents β-catenin from adherens junctions to promote cancer aggressiveness

Dawon Hong, Narae Kim, Yemin Jo, Jiwon Jeong et autres

Abstract The protein-coding sequence has long been considered the primary determinant of protein function. Alternative splicing within 3′UTRs (AS-3′UTRs) generates multiple transcript isoforms from a single gene, yet their roles in protein function and disease relevance remain largely unexplored. Through systematic transcriptome-wide …

kr (code pays fourni par la source)

DEGORA benchmark reproduction data: differential-expression tables and locked gold panels for four human stimulus-response programs, plus an Alzheimer's-disease published-DEG case study (v2)

Keunsoo Kang

Reproduction data for the DEGORA study ("DEGORA: turning heterogeneous published DEG summaries into an inspectable gene-evidence atlas"). DEGORA turns published RNA-seq and microarray differential-expression gene (DEG) tables into a local, source-traceable gene-evidence database that ranks genes by repeated, directionally consistent support across …

kr (code pays fourni par la source)

DEGORA benchmark reproduction data: differential-expression tables and locked gold panels for four human stimulus-response programs, plus an Alzheimer's-disease published-DEG case study (v2)

Keunsoo Kang

Reproduction data for the DEGORA study ("DEGORA: turning heterogeneous published DEG summaries into an inspectable gene-evidence atlas"). DEGORA turns published RNA-seq and microarray differential-expression gene (DEG) tables into a local, source-traceable gene-evidence database that ranks genes by repeated, directionally consistent support across …

kr (code pays fourni par la source)

DEGORA benchmark reproduction data: differential-expression tables and locked gold panels for four human stimulus-response programs (v1)

Keunsoo Kang

Reproduction data for the DEGORA study ("DEGORA: turning heterogeneous published DEG summaries into an inspectable gene-evidence atlas"). DEGORA turns published RNA-seq and microarray differential-expression gene (DEG) tables into a local, source-traceable gene-evidence database that ranks genes by repeated, directionally consistent support across …

kr (code pays fourni par la source)

Multi-omics study to elucidate molecular mechanism of polyhexamethylene guanidine phosphate (PHMG-p)-induced pulmonary damage in mice

Jung Dae Lee, Hyang Yeon Kim, Jueng-Eun Im, Handule Lee et autres

kr (code pays fourni par la source)

Goldnanowire integrated surface-enhanced Raman spectroscopy for multiplexed small extracellular vesicle analysis

Sila Jin, Woojeong Lim, Keunsoo Kang, An Na Seo et autres

kr (code pays fourni par la source)

A functional triangle relationship of topoisomerase IIβ, BARD1, and ERK2 in immediate early gene transcription

Heeyoun Bunch, Jaehyeon Jeong, Anh Cong, Jaeyeon Jang et autres

ABSTRACT Immediate early genes (IEGs) encode master transcription factors, including EGR1 , FOS , JUN , and MYC genes that drive robust transcription in the G1 phase of cell cycle. Our previous studies indicate that topoisomerase IIβ (TOP2B) critically regulates IEG transcription …

kr, us (code pays fourni par la source)

Promoter hypomethylation of CDH7: a novel epigenetic marker associated with cerebral small vessel disease

Jeeyeon Kim, Jihye Park, Keunsoo Kang, Young Ho Lee et autres

Introduction Cerebral small vessel disease (SVD), manifesting as white matter hyperintensities (WMH), lacunar infarctions, and cerebral microbleeds on magnetic resonance imaging (MRI), has been linked to developmental epigenetic alterations. This study aimed to identify and validate gene-specific promoter methylation changes as epigenetic …

kr (code pays fourni par la source)

Flavobacterium eburneum sp. nov., isolated from reclaimed saline land soil

Woon Mo Hwang, Dohak Kim, Keunsoo Kang, Tae-Young Ahn