František Mrázek

Blood gene expression of Toll-like receptors in SLE patients with lupus nephritis or neuropsychiatric systemic lupus erythematosus

Marketa Dudkova, Anna Petráčková, Martin Radvansky, Martina Skácelová et autres

BACKGROUND: To determine differences in the blood innate gene expression signatures of systemic lupus erythematosus (SLE) patients across various organ manifestations and disease activity, with a focus on lupus nephritis (LN) and central nervous system (CNS) involvement. METHODS: Toll-like receptor family (TLR …

cz (code pays fourni par la source)

Harmonisation of the HLA tests for the diagnosis of coeliac disease: experiences from the Czech external proficiency testing program

Milena Vraná, Jana Tajtlova, František Mrázek

Coeliac disease (CD) is an autoimmune disorder caused by the ingestion of gluten-containing grains. One of the prerequisites for the development of the disease is the presence of specific combinations of HLA alleles at the DQA1 and DQB1 loci. The HLA test …

cz (code pays fourni par la source)

Population genetics and external proficiency testing for HLA disease associations

František Mrázek

Numerous associations of HLA variants with susceptibility to diseases, namely, those with an immunopathological component, have been described to date. The strongest HLA associations were incorporated into the standard algorithms for the diagnostics. Disease-associated HLA variants are routinely detected by various techniques …

cz (code pays fourni par la source)

The novel HLA‐A*29:172 allele identified in a patient indicated for hematopoietic stem cell transplantation

František Mrázek, Sarka Pubalova, Zbyněk Novák, Nikola Mojtkova et autres

HLA-A*29:172 allele differs from HLA-A*29:01:01:01 by one missense single C/G nucleotide exchange in codon 77.

cz (code pays fourni par la source)

Cellular senescence marker p16INK4a and NFKB1 gene polymorphisms in lower gastro-intestinal acute graft versus host disease

Adam Kuba, Luděk Raida, Světlana Brychtová, Patrik Flódr et autres

Lower gastrointestinal (GI) graft versus host disease (GVHD) represents a severe complication in allogeneic hematopoietic stem cell transplant (HSCT) recipients with high rates of transplant-related mortality. Deregulated innate immunity reactions are the features of its pathogenesis. Cellular senescence has been considered a …

cz (code pays fourni par la source)

Acute GVHD Susceptible NFKB1 Gene Variants Modify Immediate Innate Immunity Reactions after Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) – Preliminary Data

Adam Kuba, Luděk Raida, František Mrázek, Eva Kriegová et autres

Genetic control of CCL24, POR, and IL23R contributes to the pathogenesis of sarcoidosis

Akira Meguro, Mami Ishihara, Martin Petřek, Ken Yamamoto et autres

Abstract Sarcoidosis is a genetically complex systemic inflammatory disease that affects multiple organs. We present a GWAS of a Japanese cohort (700 sarcoidosis cases and 886 controls) with replication in independent samples from Japan (931 cases and 1,042 controls) and the Czech …

jp, cz, us, fr (code pays fourni par la source)

Výpočetní model a analýza jízdní dynamiky vozidla

František Mrázek

P1759NEPHROTOXICITY OF CALCINEURIN INHIBITORS AS A RISK FACTOR FOR BK VIRUS REPLICATION AFTER KIDNEY TRANSPLANTATION

Karel Krejčí, Tomáš Tichý, Jana Bednaříková, Margita Bartková et autres

Abstract Background and Aims BK virus nephropathy (BKVN) represents a serious complication of kidney transplantation and is responsible for significant percentage of transplanted kidneys prematurely terminating their function. Its occurrence is considered a complication of immunosuppressive therapy and is closely related to …

cz (code pays fourni par la source)

AB0264 ARTERIAL STIFFNESS IN RHEUMATOID ARTHRITIS PATIENTS AS A POTENTIAL PREDICTOR OF EARLY CARDIOVASCULAR AGEING AND MORBIDITY

M. Schubertová, Andrea Smržová, Martina Skácelová, E. Lokočová et autres

cz (code pays fourni par la source)

Revealed heterogeneity in rheumatoid arthritis based on multivariate innate signature analysis.

Anna Petráčková, Pavel Hořák, Martin Radvanský, Regina Fillerová et autres

OBJECTIVES: A growing body of evidence highlights the persistent activation of the innate immune system and type I interferon (IFN) signature in the pathogenesis of rheumatoid arthritis (RA) and its association with disease activity. Since the recent study revealed heterogeneity in the …

cz (code pays fourni par la source)

NFKB1 gene single-nucleotide polymorphisms: implications for graft-versus-host disease in allogeneic hematopoietic stem cell transplantation

Adam Kuba, Luděk Raida, František Mrázek, Petra Schneiderová et autres

cz (code pays fourni par la source)